全文获取类型
收费全文 | 1047篇 |
免费 | 19篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 15篇 |
化学工业 | 121篇 |
金属工艺 | 17篇 |
机械仪表 | 19篇 |
建筑科学 | 45篇 |
矿业工程 | 3篇 |
能源动力 | 10篇 |
轻工业 | 67篇 |
水利工程 | 3篇 |
石油天然气 | 1篇 |
无线电 | 78篇 |
一般工业技术 | 97篇 |
冶金工业 | 531篇 |
原子能技术 | 5篇 |
自动化技术 | 55篇 |
出版年
2020年 | 6篇 |
2019年 | 4篇 |
2018年 | 7篇 |
2017年 | 8篇 |
2016年 | 14篇 |
2015年 | 7篇 |
2014年 | 9篇 |
2013年 | 31篇 |
2012年 | 19篇 |
2011年 | 27篇 |
2010年 | 21篇 |
2009年 | 26篇 |
2008年 | 21篇 |
2007年 | 28篇 |
2006年 | 16篇 |
2005年 | 20篇 |
2004年 | 23篇 |
2003年 | 15篇 |
2002年 | 17篇 |
2001年 | 7篇 |
2000年 | 14篇 |
1999年 | 16篇 |
1998年 | 136篇 |
1997年 | 71篇 |
1996年 | 80篇 |
1995年 | 35篇 |
1994年 | 23篇 |
1993年 | 33篇 |
1992年 | 15篇 |
1991年 | 10篇 |
1990年 | 9篇 |
1989年 | 8篇 |
1988年 | 15篇 |
1987年 | 4篇 |
1986年 | 9篇 |
1985年 | 9篇 |
1983年 | 12篇 |
1982年 | 19篇 |
1981年 | 17篇 |
1980年 | 20篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1977年 | 37篇 |
1976年 | 46篇 |
1975年 | 8篇 |
1973年 | 4篇 |
1965年 | 5篇 |
1964年 | 4篇 |
1954年 | 6篇 |
1941年 | 4篇 |
排序方式: 共有1067条查询结果,搜索用时 15 毫秒
1.
PE Sipila VJ Wiebe GB Hubbard SK Koester VD Emshoff JU Maenpaa GT Wurz RC Seymour MW DeGregorio 《Canadian Metallurgical Quarterly》1993,(15):2138-2144
The effects of long-term tamoxifen exposure on cell growth and cell cycle kinetics were compared between oestrogen receptor (ER)-positive (MCF-7) and ER-negative (MDA-MB-231) cell lines. In the MCF-7 cell line, prolonged tamoxifen exposure (0.5 mumol/l for > 100 days) blocked cells in G0-G1 of the cell cycle, and slowed the doubling time of cells from 30 to 59 h. These effects corresponded to an increase in the cellular accumulation of tamoxifen over time [mean area under concentration curve (AUC) = 77.92 mumoles/10(6)/cells/day]. In contrast, in the MDA-MB-231 cell line, long-term tamoxifen exposure had no obvious effect on the doubling time, and reduced cellular tamoxifen accumulation (mean AUC = 50.50 mumoles/10(6)/cells/day) compared to the MCF-7 cells. Flow cytometric analysis of MDA-MB-231 cells demonstrated that a new tetraploid clone emerged following 56 days of tamoxifen exposure. Inoculation of the MDA-MB-231 tetraploid clone and MDA-MB-231 wildtype cells into the opposite flanks of athymic nude mice resulted in the rapid growth of tetraploid tumours. The tetraploid tumours maintained their ploidy following tamoxifen treatment for nine consecutive serial transplantations. Histological examination of the fifth transplant generation xenografts revealed that the tetraploid tumour had a 25-30 times greater mass, area of haemorrhage and necrosis, a slightly higher mitotic index and was more anaplastic than the control neoplasm. The control wildtype MDA-MB-231 tumours maintained a stable ploidy following tamoxifen treatment until the eighth and ninth transplantation, when a tetraploid population appeared, suggesting that tamoxifen treatment may select for this clone in vivo. These studies suggest that prolonged tamoxifen exposure may select for new, stable, fast growing cell clones in vitro as well as in vivo. 相似文献
2.
3.
The tentative standard impact test procedure, adopted by the Porcelain Enamel Institute, was used to test and compare cylinders coated with several experimental and commercial enamels. The important facts noted were (1) the effect of cubic thermal expansion on the impact resistance, (2) the importance of the ground coat to the resistance of any one cover enamel, and (3) the wide variation between cover enamels in resistance to impact. 相似文献
4.
CM Wheeler CA Parmenter WC Hunt TM Becker CE Greer A Hildesheim MM Manos 《Canadian Metallurgical Quarterly》1993,20(5):286-289
OBJECTIVES: To confirm the risk factors for genital human papillomavirus (HPV) infection. GOAL OF THIS STUDY: To investigate risk factors for HPV detection apart from the correlated risk factors for cervical neoplasia. STUDY DESIGN: Cervical human papillomavirus (HPV) DNA was assessed in 357 cytologically normal women attending the University of New Mexico student health center. Cervical swab samples were obtained for HPV DNA detection and typing using a PCR-based DNA amplification system. Possible determinants of cervical HPV were examined including age, ethnicity, history of sexually transmitted disease, oral contraceptive use, smoking, age at first intercourse, lifetime number of sex partners, marital status, and history of pregnancy. RESULTS: A 44.3% overall prevalence of cervical HPV was observed. On univariate analysis, factors associated with increasing HPV prevalence included higher lifetime number of sex partners and single marital status. After adjustment for potential confounding variables, we found that HPV prevalence increased with higher lifetime number of sexual partners. CONCLUSION: These findings, along with those from the companion reports in this issue of the journal, support the sexual route of transmission of the virus. 相似文献
5.
Salinger Walter L.; Ladrow Pamela; Wheeler Catherine 《Canadian Metallurgical Quarterly》2003,117(6):1257
Reeler (rl/rl) and reeler/wild-type (+/rl) mice synthesize Reln at subnormal rates, as do patients with schizophrenia, bipolar disorder, and autism, thereby forming the basis for a Reln hypothesis for vulnerability to these psychopathologies and justifying attention to the behavioral phenotypes of Reln-deficient mice. Tests of gait, emotionality, social aggression, spatial working memory, novel-object detection, fear conditioning, and sensorimotor reflex modulation revealed the behavioral phenotype of rl/rl, but not +/rl, mice to be different from that of wild-type (+/+) mice. These results reveal no effect of Reln gene dosage and provide significant challenges to both the Reln and the neurodevelopmental hypotheses of the etiology of major psychopathologies. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
Analysis of the function of the nervous system, based on clinical, neurological, and psychological studies in 78 patients with generalized periodontitis, revealed central regulation disorders without signs of organic lesions of the brain in 76% patients. The authors claim that stress and a high level of personal anxiety may be responsible for the development of these disorders, which was confirmed by the results of psychological testing. 相似文献
7.
VD Samuilov Borisov AYu EL Barsky OF Borisova AV Kitashov 《Canadian Metallurgical Quarterly》1998,46(2):333-341
Obese (Lepr(fa)/Lepr(fa)) Zucker rats have a missense mutation in the leptin receptor gene. One amino acid substitution in the extracellular domain common to all known leptin receptor proteins results from this mutation. Obese Zucker rats are unable to respond behaviorally to leptin which is peripherally administered. However, conflicting reports exist on whether obese Zucker rats can respond to centrally administered leptin. The purpose of this study was to determine whether obese Zucker rats responded behaviorally and metabolically to intracerebroventricularly (i.c.v.) administered leptin and to compare the responses of lean and obese Zucker rats. We found that both lean and obese Zucker rats had similar body weight and food intake responses when administered a single i.c.v. leptin injection in a range of doses (1.25, 2.5, 5, and 10 microg), as well as daily i.c.v. administered leptin for five consecutive days. Both single and daily leptin administration also decreased respiratory quotient (RQ) similarly in lean and obese Zucker rats, indicating mobilization of fat as an energy source for leptin-treated rats. After withdrawal of daily leptin treatment, lean and obese Zucker rats exhibited different recovery responses. It is concluded that obese Zucker rats can respond to exogenous leptin when leptin is delivered into the brain ventricles. 相似文献
8.
MJ Kania SD Keeling SP McGorray TT Wheeler GJ King 《Canadian Metallurgical Quarterly》1996,66(6):423-432
This study examined risk factors associated with incisor injury in 3396 third and fourth grade school children in Alachua County, Florida. One of six orthodontists completed a standardized examination form for each child to assess severity of incisor injury, gender, age, race, skeletal relationships, morphologic malocclusion, incisor exposure, interlabial gap, TMJ sounds, chin trauma, and history of lower facial trauma. One in five (19.2%) exhibited some degree of incisor injury. This was limited to a single tooth in 73.1% of those with injury, while enamel injury predominated (89.4%). The majority of the injuries (75.4%) were localized in the maxillary arch, with central incisors the most frequently traumatized. Chi-square tests of association indicated that gender, race, school, orthodontist, history of lower facial trauma, chin trauma, profile, and maxillary and mandibular horizontal positions were associated with incisor injury (P < 0.05). Wilcoxon rank sum tests identified differences in age, overjet, time of screening, and interlabial gap between those with and without injury (P < 0.05). Results of logistic regression analyses indicated risk of incisor injury was greater for children who had a prognathic maxilla, a history of trauma, were older, were male, and had greater overjet and mandibular anterior spacing. 相似文献
9.
10.
Tomarken Andrew J.; Davidson Richard J.; Wheeler Robert E.; Doss Robert C. 《Canadian Metallurgical Quarterly》1992,62(4):676
Assessed whether individual differences in anterior brain asymmetry are linked to differences in basic dimensions of emotion. In each of 2 experimental sessions, separated by 3 wks, resting EEG activity was recorded from female adults during 8 60-sec baselines. Mean alpha power asymmetry across both sessions was extracted in mid-frontal and anterior temporal sites. Across both regions, groups demonstrating stable and extreme relative left anterior activation reported increased generalized positive affect (PAF) and decreased generalized negative affect (NAF) compared with groups demonstrating stable and extreme relative right anterior activation. Additional correlational analyses revealed robust relations between anterior asymmetry and PAF and NAF, particularly among Ss who demonstrated stable patterns of EEG activation over time. Anterior asymmetry was unrelated to individual differences in generalized reactivity. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献