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Landsiedel Justus Root Waleri Schramm Christian Menzel Alexander Witzleben Steffen Bechtold Thomas Pham Tung 《Nano Research》2020,13(10):2658-2664
Nano Research - Development of colored surfaces by formation of nano-structured aggregates is a widely used strategy in nature to color lightweight structures (e.g. butterflies) without the use of... 相似文献
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Anne Bernhardt Jasmin Skottke Max von Witzleben Michael Gelinsky 《International journal of molecular sciences》2021,22(14)
In vitro evaluation of bone graft materials is generally performed by analyzing the interaction with osteoblasts or osteoblast precursors. In vitro bone models comprising different cell species can give specific first information on the performance of those materials. In the present study, a 3D co-culture model was established comprising primary human osteoblasts, osteoclasts and osteocytes. Osteocytes were differentiated from osteoblasts embedded in collagen gels and were cultivated with osteoblast and osteoclasts seeded in patterns on a porous membrane. This experimental setup allowed paracrine signaling as well as separation of the different cell types for final analysis. After 7 days of co-culture, the three cell species showed their typical morphology and gene expression of typical markers like ALPL, BSPII, BLGAP, E11, PHEX, MEPE, RANKL, ACP5, CAII and CTSK. Furthermore, relevant enzyme activities for osteoblasts (ALP) and osteoclasts (TRAP, CTSK, CAII) were detected. Osteoclasts in triple culture showed downregulated TRAP (ACP5) and CAII expression and decreased TRAP activity. ALP and BSPII expression of osteoblasts in triple culture were upregulated. The expression of the osteocyte marker E11 (PDPN) was unchanged; however, osteocalcin (BGLAP) expression was considerably downregulated both in osteoblasts and osteocytes in triple cultures compared to the respective single cultures. 相似文献
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Hahlweg Kurt; Fiegenbaum Wolfgang; Frank Monika; Schroeder Brigitte; von Witzleben Ines 《Canadian Metallurgical Quarterly》2001,69(3):375
This study examined the effectiveness of individual high-density exposure (2–3 weeks, all day) for panic disorder with agoraphobia (PDAG). Participants were 416 unselected patients with a primary diagnosis of PDAG who were treated by 52 therapists in 3 outpatient clinics of the Christoph-Dornier Foundation of Clinical Psychology in Germany. Results 6 weeks after the end of therapy and at the 1-year follow-up showed highly significant reductions in anxiety symptoms, anxious cognition, agoraphobic avoidance, general symptomatology, and depressive symptoms. Results did not differ significantly between the 3 outpatient clinics and are comparable with the average effect sizes reported by meta-analytic studies of controlled efficacy research, using selected patients and specifically trained therapists. Effectiveness was not dependent on duration of disorder, number of treatment sessions, and therapist experience. The study suggests that high-density exposure can be transported from research settings to the mental health field. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Various metal oxides were investigated using laser pulse photo-electromotive force measurements. This method is possible if the band gap of these oxides is smaller than the laser radiation energy. The sign of the photovoltage and its decay rate depend on the specific surface potential, which is influenced by adsorption layers. The adsorption of acids and bases on ZnO, TiO2, -Fe2O3 and -Fe2O3 microcrystals shows the dependence of the photovoltage on the type of space charge layer on the surface of the oxides. Oxides with a depletion layer exhibit a rising photovoltage with rising pH, whilst oxides with an accumulation layer at the surface exhibit the opposite behaviour. 相似文献
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AH Greenhill ME Norman D Cornfeld J Chatten B Buck CL Witzleben 《Canadian Metallurgical Quarterly》1977,8(3):400-403
A six year-old girl presented with acute oliguric renal failure, secondary to acute, non-obstructive pyelonephritis. Evidence for pyelonephritis as the cause of renal failure included: the evolution of typical changes on serial intravenous pyelograms, an acute interstitial inflammatory exudate on percutaneous renal biopsy, and gram-positive cocci on gram stain of the biopsy tissue. Although a specific causative organism was not conclusively identified, enterococcus was isolated from the initial catheterized urine specimen. The patient recovered from the acute illness but was left with impaired renal function, hypertension, and cortical scarring. Acute, non-obstructive pyelonephritis can produce acute renal failure in children and must be considered in the differential diagnosis of this syndrome. 相似文献
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