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排序方式: 共有497条查询结果,搜索用时 15 毫秒
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2.
Valence M. K. Ndesendo Yahya E. Choonara Leith C. R. Meyer Pradeep Kumar Lomas K. Tomar Charu Tyagi 《Drug development and industrial pharmacy》2015,41(8):1274-1287
Context and objective: The aim of this study was to develop, characterize and evaluate a mucoadhesive caplet resulting from a polymeric blend (polymeric caplet) for intravaginal anti-HIV-1 delivery.Materials and methods: Poly(lactic-co-glycolic) acid, ethylcellulose, poly(vinylalcohol), polyacrylic acid and modified polyamide 6, 10 polymers were blended and compressed to a caplet-shaped device, with and without two model drugs 3′-azido-3′-deoxythymidine (AZT) and polystyrene sulfonate (PSS). Thermal analysis, infrared spectroscopy and microscopic analysis were carried out on the caplets employing temperature-modulated DSC (TMDSC), Fourier transform infra-red (FTIR) spectrometer and scanning electron microscope, respectively. In vitro and in vivo drug release analyses as well as the histopathological toxicity studies were carried out on the drug-loaded caplets. Furthermore, molecular mechanics (MM) simulations were carried out on the drug-loaded caplets to corroborate the experimental findings.Results and discussion: There was a big deviation between the Tg of the polymeric caplet from the Tg's of the constituent polymers indicating a strong interaction between constituent polymers. FTIR spectroscopy confirmed the presence of specific ionic and non-ionic interactions within the caplet. A controlled near zero-order drug release was obtained for AZT (20 d) and PSS (28 d). In vivo results, i.e. the drug concentration in plasma ranged between 0.012–0.332?mg/mL and 0.009–0.256?mg/mL for AZT and PSS over 1–28 d.Conclusion: The obtained results, which were corroborated by MM simulations, attested that the developed system has the potential for effective delivery of anti-HIV-agents. 相似文献
3.
Fretting fatigue is one of the most important phenomena for inducing a significant reduction of fatigue strength and consequently,
leading to unexpected failure accidents of the engineering structures even at very low stresses. In the present study, both
plain and fretting fatigue tests with zero mean stress were carried out on two different types of steel, low-carbon steel
and martensitic stainless steel, by means of a reversed bending fatigue testing machine. The drop in the fatigue strengths
through fretting at vise clamp-specimen interface were significant for both tested steels. The fretting processes produced
a reduction in fatigue strength of about 27% for low-carbon steel and 16% for martensitic stainless steel. 相似文献
4.
Amir Hamzeh Haghiabi 《Water Resources Management》2017,31(3):811-824
Modeling river mixing mechanism in terms of pollution transmission in rivers is an important subject in environmental studies. Dispersion coefficient is an important parameter in river mixing problem. In this study, to model and predict the longitudinal dispersion coefficient (D L ) in natural streams, two soft computing techniques including multivariate adaptive regression splines (MARS) as a new approach to study hydrologic phenomena and multi-layer perceptron neural network as a common type of neural network model were prepared. To this end, related dataset were collected from literature and used for developing them. Performance of MARS model was compared with MLP and the empirical formula was proposed to calculate D L . To define the most effective parameters on D L structure of obtained formula from MARS model and more accurate formula was evaluated. Calculation of error indices including coefficient of determination (R2) and root mean square error (RMSE) for the results of MARS model showed that MARS model with R2?=?0.98 and RMSE?=?0.89 in testing stage has suitable performance for modeling D L . Comparing the performance of empirical formulas, ANN and MARS showed that MARS model is more accurate compared to others. Attention to the structure of developed MARS and the most accurate empirical formulas model showed that flow velocity, depth of flow (H) and shear velocity are the most influential parameters on D L . 相似文献
5.
Rahim Asma Durrani Mehr Yahya Gillani Saira Ali Zeeshan Hasan Najam Ul Kim Mucheol 《The Journal of supercomputing》2022,78(3):3184-3204
The Journal of Supercomputing - Smart services are a concept that provides services to the citizens in an efficient manner. The online shopping and recommender system can play an important role for... 相似文献
6.
Stratified concrete poses a promising alternative for construction. Its fresh and hardened properties have been studied at the material level; however, structural behavior in steel reinforced specimens has not been studied. This paper focuses on the flexural behavior of eight stratified reinforced concrete (SRC) specimens representing slices from a slab or non-bearing wall. Specimens with two stratified concrete designs and three steel ratios were tested and compared to estimates from a fiber element numerical model and rectangular stress-block design methods from ACI 318 and Eurocode 2. The results suggest that SRC has similar damage modes as ordinary reinforced concrete (ORC). The fiber element model accurately estimated the measured behavior, while ACI 318 and Eurocode 2 differed from the experimental results by <25%. These prediction accuracies are similar to those for ORC. Therefore, the flexural design of SRC can be done using both fiber element and rectangular stress-block approaches. 相似文献
7.
Zainal Abidin Ali Muhammad Aidil Roslan Rosiyah Yahya Wan Yusoff Wan Sulaiman Rustam Puteh 《IET nanobiotechnology / IET》2017,11(2):152
In this study, larvicidal activity of silver nanoparticles (AgNPs) synthesised using apple extract against fourth instar larvae of Aedes aegypti was determined. As a result, the AgNPs showed moderate larvicidal effects against Ae. aegypti larvae (LC50 = 15.76 ppm and LC90 = 27.7 ppm). In addition, comparison of larvicidal activity performance of AgNPs at high concentration prepared using two different methods showed that Ae. aegypti larvae was fully eliminated within the duration of 2.5 h. From X‐ray diffraction, the AgNP crystallites were found to exhibit face centred cubic structure. The average size of these AgNPs as estimated by particle size distribution was in the range of 50–120 nm. The absorption maxima of the synthesised Ag showed characteristic Ag surface plasmon resonance peak. This green synthesis provides an economic, eco‐friendly and clean synthesis route to Ag.Inspec keywords: silver, nanofabrication, X‐ray diffraction, zoology, particle size, nanoparticles, biomedical materials, nanomedicineOther keywords: time 2.5 h, size 50 nm to 120 nm, silver nanoparticle, larvicidal property, instar larvae, Aedes aegypti, larvicidal effect, larvicidal activity performance, X‐ray diffraction, nanoparticle particle size distribution, absorption maxima, silver surface plasmon resonance peak 相似文献
8.
Helge Klippstein Hany Hassanin Alejandro Diaz De Cerio Sanchez Yahya Zweiri Lakmal Seneviratne 《Advanced Engineering Materials》2018,20(9)
9.
Ahmed Abdu Alattab Mohammed Eid Ibrahim Reyazur Rashid Irshad Anwar Ali Yahya Amin A. Al-Awady 《计算机、材料和连续体(英文)》2023,74(2):2397-2412
This research proposes a machine learning approach using fuzzy logic to build an information retrieval system for the next crop rotation. In case-based reasoning systems, case representation is critical, and thus, researchers have thoroughly investigated textual, attribute-value pair, and ontological representations. As big databases result in slow case retrieval, this research suggests a fast case retrieval strategy based on an associated representation, so that, cases are interrelated in both either similar or dissimilar cases. As soon as a new case is recorded, it is compared to prior data to find a relative match. The proposed method is worked on the number of cases and retrieval accuracy between the related case representation and conventional approaches. Hierarchical Long Short-Term Memory (HLSTM) is used to evaluate the efficiency, similarity of the models, and fuzzy rules are applied to predict the environmental condition and soil quality during a particular time of the year. Based on the results, the proposed approaches allows for rapid case retrieval with high accuracy. 相似文献
10.
Samer Yahya M. Moghavvemi Haider A.F. Mohamed 《Simulation Modelling Practice and Theory》2011,19(1):406-422
A new method for inverse kinematics for hyper-redundant manipulators is proposed in this paper to plan the path of the end-effector. The basic idea is that for a given smooth path consisting of points close enough to each other; computing the inverse kinematics for these points is carried out geometrically using the proposed method. In this method, the angles between the adjacent links are set to be the same, which makes lining up of two or more joint axes impossible; therefore, avoiding singularities. The manipulability index has been used to show how far the manipulator from the singularity configuration is. The determination of the workspace of the manipulator using the proposed method has been presented in this paper. The simulation results have been carried out on a planar and a three dimensional manipulators. The effectiveness of the proposed method is clearly demonstrated by comparing its result with results calculated by the well-known method of measuring manipulability which is used for singularity avoidance for the last two decades. 相似文献