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排序方式: 共有2717条查询结果,搜索用时 234 毫秒
1.
Ping Xiao Jue Wang Lei Fang Zitong Zhao Xiangshi Sun Xiaochen Liu Haiqiang Cao Pengcheng Zhang Dangge Wang Yaping Li 《Advanced functional materials》2021,31(36):2104068
Neoantigen vaccines and adoptive dendritic cell (DC) transfer are major clinical approaches to initiate personalized immunity in cancer patients. However, the immunization efficacy is largely limited by the in vivo trajectory including neoantigens’ access to resident DCs and DCs’ access to lymph nodes (LNs). Herein, an innovative strategy is proposed to improve personalized immunization through neoantigen-loaded nanovaccines synergized with adoptive DC transfer. It is found that it enables selective delivery of neoantigens to resident DCs and macrophages by coating cancer cell membranes onto neoantigen-loaded nanoparticles. In addition, the nanovaccines promote the secretion of chemokine C-C motif ligand 2 (CCL2), CCL3, and C-X-C motif ligand 10 from macrophages, thus potentiating the access of transferred DCs to LNs. This immunization strategy enables coordinated delivery of identified neoantigens and autologous tumor lysate-derived undefined antigens, leading to initiation of antitumor T cell immunity in a personalized manner. It significantly inhibits tumor growth in prophylactic and established mouse tumor models. The findings provide a new vision for potentiating adoptive cell transfer by nanovaccines, which may open the door to a transformative possibility for improving personalized immunization. 相似文献
2.
AbstractDifferent drying methods (spray drying (SD), vacuum drying (VD), microwave vacuum drying (MVD), and infrared vacuum drying (IFVD)) were applied in order to compare the hygroscopicity behavior of chicken powders. The hygroscopicity curves and glass transition temperature were used to evaluate the influence of ambient humidity and temperature on moisture absorption of powders. The results showed that the chicken powder dried by MVD had the lowest moisture absorption, followed by IFVD, VD, and SD. The hygroscopicity of SD chicken powders was different from other three kinds of chicken powders due to the physical properties of particles and the changes of protein secondary structure as detected by the Fourier transform-infrared spectrometer. For the three vacuum drying methods, the difference of protein secondary structure was the main reason of differences in hygroscopicity. Although MVD chicken powders were slightly inferior to SD chicken powders in taste, MVD chicken powders were the best in terms of smell and color as suggested by instrumental sensory parameter evaluations. It was found that MVD had a positive effect on reducing moisture absorption and maintaining sensory quality of chicken powders. 相似文献
3.
不同折流板结构螺旋折流板换热器传热性能的比较(英文) 总被引:1,自引:0,他引:1
Numerical simulations were performed on flow and heat transfer performances of heat exchangers having six helical baffles of different baffle shapes and assembly configurations, i.e., two trisection baffle schemes, two quadrant baffle schemes, and two continuous helical baffle schemes. The temperature contour or the pressure contour and velocity contour plots with superimposed velocity vectors on meridian, transverse and unfolded concentric hexagonal slices are presented to obtain a full angular view. For the six helix baffled heat exchangers, the different patterns of the single vortex secondary flow and the shortcut leakage flow were depicted as wel as the heat transfer properties were compared. The results show that the optimum scheme among the six configurations is a circumferential overlap trisection helix baffled heat exchanger with a baffle incline angle of 20° (20°TCO) scheme with an anti-shortcut baffle structure, which exhibits the second highest pressure dropΔpo, the highest overal heat transfer coefficient K, shel-side heat transfer coefficient ho and shel-side average comprehensive index ho/Δpo. 相似文献
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从分析石油焦原料着手,考察了其热解特性、孔隙率和石墨化程度。由于石油焦结构致密,属易石墨化碳,因此用水蒸气法直接活化得到的炭质材料吸附性能差,其碘吸附值小于350mg/g。不同来源的石油焦由于组成不同,其活化性能也有差异。通过成型法,以金山石油焦为原料轻预炭化、预氧化和炭化,得到炭化料,再用水蒸气活化得到的活性炭的碘吸附值达800.40mg/g、亚甲蓝值达120.40mg/g。以独山子石油焦为主要原料制得的活性炭的碘吸附值与亚甲蓝值分别达871.58mg/g、100..67mg/g。 相似文献
6.
HAP陶瓷合成的研究 总被引:2,自引:0,他引:2
本文对生物陶瓷材料-羟基磷灰石的合成进行了研究。试验将激光合成与湿法合成对比分析,着重探讨了在激光辐照下生物陶瓷的形貌,粒度,化学组成和结构等的变化规律,对激光涂敷生物陶瓷涂层有一定的指导意义。 相似文献
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Yaping KeLU 《材料科学技术学报》2002,18(6):492-496
In this paper,glass transition and thermal stability of the Zr-Al-Cu-Ni metallic glasses were investigated by using electrical resistance measurement(ERM),DSC and X-ray diffraction techniques.The experimental results show that the ERM is capable of detecting the glass transition of the amorphous alloys and can help to distinguish the crystallization products of the Zr-Al-Cu-Ni metallic glasses owing to the difference of the electrical resistivity between the precipitation phases. 相似文献
10.
在分步设计及大量计算的基础上,提出了一套考虑因素相对全面、指导 性强、易于操作的梯级水库电力实用优化调度图。该调度图继承了传统时历法调度图直观、 简明的优点,又具有其特有的优化功能。该方法以汛末蓄满水库为标准,确定典型来水过程 的预调度线和初始目标;以获得梯级电站最大长期调峰收益为目标,以变动目标水位控制为 核心,开发出调度图长系列操作通用程序模块,并以此模块作为寻优计算的手段。提出了水 库长期运行与短期实时调度有机结合,以及模拟计算、水位偏差最优反馈、来水预报、目标 水位寻优等多种实用处理技术。 相似文献