The Role of microRNAs in Development of Colitis-Associated Colorectal Cancer

Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transformation. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes’ expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precision treatment.     

The method of double averaging: an approach for modeling power-factor-correction switching converters

This paper describes the modeling of power-factor-correction converters under average-current-mode control, which are widely used in switch-mode power supply applications. The objective is to identify stability boundaries in terms of major circuit parameters for facilitating design of such converters. The approach employs a double averaging procedure, which first applies the usual averaging over the switching period and subsequently applies generalized averaging over the mains period. The resulting model, after two averaging steps and application of a harmonic balance procedure, is nonlinear and capable of describing the low-frequency nonlinear dynamics of the system. The parameter ranges within which stable operation is guaranteed can be accurately and easily found using this model. Experimental measurements are provided for verification of the analytical results.     

Long multifilament Bi-2223 Ag-sheathed superconducting tapes and solenoids

Multifilament Ag-sheathed BiPbSrCaCuO (2223) superconducting tapes containing 49 filaments were fabricated by the powder-in-tube route and the roll-anneal process. The transport critical current densityJ _c was 1.3×10⁴ A cm^–2 at 77 K and 7×10⁴ A cm^–2 at 4.2 K in self-field. A 12-m-long tape was used to construct superconducting solenoids (50, 28, and 14 mm internal diameters) generating dc fields 380–1070 G at 4.2 K. Measurements of the variation ofJ _c with field (0–1.6 T) and bend strain (0–5%) are used to explain the performance of the solenoids. The critical bend strain of tapes was about 1.5%.     

A novel method for elimination of line-current harmonics insingle-stage PFC switching regulators

This paper studies a particular single-stage power-factor-correction (PFC) switching regulator employing a discontinuous-conduction-mode (DCM) boost-input cell and a continuous-current-mode (CCM) forward output cell. Although this single-stage PFC regulator can provide a reasonably high power factor when its PFC stage is operating in discontinuous mode, substantial reduction in line-current harmonics is possible by applying a suitable frequency-modulation scheme. This paper derives a frequency-modulation scheme and proposes a practical implementation using a simple translinear analog circuit. A quantitative analysis on the total harmonic distortion (THD) of the line current when the circuit is subject to a limited range of frequency variations is presented along with some considerations for practical design. Experimental data obtained from a prototype confirms the effectiveness of the proposed frequency-modulation scheme. The proposed analog translinear circuit allows custom integrated circuit implementation, making it a viable low-cost solution to the elimination of line-current harmonics in switching regulators     

The stress-whitened damage zone of PVC blends

The stress-whitened damage zone that formed ahead of a semicircular notch during slow tensile loading has been measured from optical micrographs of translucent blends of poly(vinyl chloride) (PVC) with experimental chlorinated polyethylene (CPE) resins. When the zone was small, the plane strain condition applied and from the elastic stress distribution a constant mean stress condition was found at the boundary of the crescent-shaped zone. The critical mean stress did not depend on the chlorine content or the chlorine distribution of the experimental CPE resin used in the blend. While the critical mean stress decreased as the amount of CPE in the blend was increased, the critical volume strain, calculated from the bulk modulus, was independent of composition and was thought to be the controlling parameter for stress-whitening. When the zone was larger, the shape was qualitatively described by concepts of stress redistribution in the presence of a plastic zone ahead of the notch. Macroscopic flow and necking were only detected near the maximum in the stress-displacement curve.     

New Solution Approaches to the General Single- Machine Earliness-Tardiness Problem

This paper addresses the general single-machine earliness-tardiness problem with distinct release dates, due dates, and unit costs. The aim of this research is to obtain an exact nonpreemptive solution in which machine idle time is allowed. In a hybrid approach, we formulate and then solve the problem using dynamic programming (DP), while incorporating techniques from branch-and-bound (BB). This approach (DP-BB) has been proven to be effective in solving certain types of scheduling problems. We further propose a new adaptation of the approach to a general problem with a nonregular objective function. To address some shortcomings of DP-BB, we also apply a BB approach in which partial dynamic programming dominance (BB-PDP) is exploited. Computational experiments were conducted with randomly generated test instances in order to evaluate the effectiveness of the two approaches. The results clearly showed that our new approaches can solve all the instances with up to 40 jobs and most of the instances with 50 jobs, which outperforms those frequently used approaches in scheduling research.     

Hot-carrier degradation of submicrometer p-MOSFETs withthermal/LPCVD composite oxide

It is shown that while gate oxides containing thermal/LPCVD composite oxide have lower defect densities than gates using only thermal oxides, they are more susceptible to hot-carrier degradation. The hot-carrier-induced degradation of composite oxides is worse in p-channel MOSFETs than in n-channel MOSFETs. This sensitivity of p-channel MOSFETs is caused by higher electron trapping levels in LPCVD oxides. For 150-Å gate technology, the hot-carrier-degradation resistance of thermal/LPCVD composite gate oxides with a 70-Å or thicker thermal oxide layer approaches that of high-quality pure thermal oxide     

Adaptive Fault Monitoring in All-Optical Networks Utilizing Real-Time Data Traffic

We propose a novel fault detection and localization scheme for all-optical networks with the information of real-time data traffic. Our adaptive fault localization framework is based on combining passive and proactive monitoring solutions, together with adaptive management in two phases. Numerical results indicate that our proposed scheme has good scalability, in terms of the number of fault monitors required. Also, we show that our framework allows more flexible network design, and requires much less monitoring bandwidth when compared with the passive monitoring solutions.