全文获取类型
收费全文 | 240篇 |
免费 | 5篇 |
国内免费 | 9篇 |
专业分类
电工技术 | 7篇 |
综合类 | 1篇 |
化学工业 | 18篇 |
金属工艺 | 2篇 |
机械仪表 | 3篇 |
建筑科学 | 7篇 |
能源动力 | 10篇 |
轻工业 | 19篇 |
水利工程 | 12篇 |
石油天然气 | 3篇 |
无线电 | 5篇 |
一般工业技术 | 15篇 |
冶金工业 | 148篇 |
原子能技术 | 1篇 |
自动化技术 | 3篇 |
出版年
2024年 | 4篇 |
2023年 | 2篇 |
2022年 | 4篇 |
2021年 | 9篇 |
2020年 | 2篇 |
2019年 | 3篇 |
2018年 | 5篇 |
2017年 | 8篇 |
2016年 | 3篇 |
2015年 | 3篇 |
2014年 | 7篇 |
2013年 | 7篇 |
2012年 | 10篇 |
2011年 | 6篇 |
2010年 | 5篇 |
2009年 | 1篇 |
2008年 | 4篇 |
2007年 | 5篇 |
2003年 | 9篇 |
1999年 | 4篇 |
1998年 | 35篇 |
1997年 | 33篇 |
1996年 | 16篇 |
1995年 | 8篇 |
1994年 | 8篇 |
1993年 | 6篇 |
1991年 | 1篇 |
1987年 | 2篇 |
1985年 | 2篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1977年 | 7篇 |
1976年 | 28篇 |
排序方式: 共有254条查询结果,搜索用时 15 毫秒
1.
K Papadakis FI Luks ME De Paepe GJ Piasecki CW Wesselhoeft 《Canadian Metallurgical Quarterly》1997,32(2):347-351
We investigated cell proliferation and cell death in the olfactory epithelium (OE) of mice from birth to maturity using bromodeoxyuridine and terminal deoxynucleotidyl transferase nick end labeling. We show that cell death events and proliferative activity diminish concomitantly with age in the OE. Thus, the age-dependent and coordinate diminution in cell proliferative activity and cell death events may serve to maintain the thickness of the OE as mice mature and age. 相似文献
2.
TL Tomusiak FI Mamchur NV Zeliak LT Kisilevich ZR Matsun IN Gurvits 《Canadian Metallurgical Quarterly》1993,(3):11-13
Long-term (1-10 years) results of wandering kidney surgery were followed-up for 118 patients. The outcomes were found dependent on the duration of the disease, variety and severity of the lesion, age of the patients. The response appeared better in younger patients, in those with shorter duration of the disease and with unessential changes in the kidney. Recommendations are provided on the regimens, jobs, outpatient and inpatient follow-up for the subjects treated surgically for wandering kidney to reinforce the correction results achieved. 相似文献
3.
4.
JB Thomas MJ Fall JB Cooper RB Rothman SW Mascarella H Xu JS Partilla CM Dersch KB McCullough BE Cantrell DM Zimmerman FI Carroll 《Canadian Metallurgical Quarterly》1998,41(26):5188-5197
A three-component library of compounds was prepared in parallel using multiple simultaneous solution-phase synthetic methodology. The compounds were biased toward opioid receptor antagonist activity by incorporating (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine (a potent, nonselective opioid pure antagonist) as one of the monomers. The other two monomers, which included N-substituted or unsubstituted Boc-protected amino acids and a range of substituted aryl carboxylic acids, were selected to add chemical diversity. Screening of these compounds in competitive binding experiments with the kappa opioid receptor selective ligand [3H]U69,593 led to the discovery of a novel kappa opioid receptor selective ligand, N-?(2'S)-[3-(4-hydroxyphenyl)propanamido]-3'-methylbutyl?-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine (8, RTI-5989-29). Additional structure-activity relationship studies suggested that 8 possesses lipophilic and hydrogen-bonding sites that are important to its opioid receptor potency and selectivity. These sites appear to exist predominantly within the kappa receptor since the selectivity arises from a 530-fold loss of affinity of 8 for the mu receptor and an 18-fold increase in affinity for the kappa receptor relative to the mu-selective ligand, (+)-N-[trans-4-phenyl-2-butenyl]-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine (5a). The degree of selectivity observed in the radioligand binding experiments was not observed in the functional assay. According to its ability to inhibit agonist stimulated binding of [35S]GTPgammaS at all three opioid receptors, compound 8 behaves as a mu/kappa opioid receptor pure antagonist with negligible affinity for the delta receptor. 相似文献
5.
SA Nachman FI Chasalow M Navaie-Waliser SL Blethen P Tropper 《Canadian Metallurgical Quarterly》1996,16(6):449-454
We measured human chorionic gonadotropin (hCG) in cord sera of 22 infants born to women infected with the human immunodeficiency virus-1 (HIV-1). hCG was also determined in cord sera from 173 infants born at a suburban hospital to HIV-1-seronegative women. The findings indicate that 16 (9%) of 173 HIV-1-seronegative samples had hCG levels greater than 90 IU/L (values were distributed as a Poisson curve). In contrast, 8 (36%) of the 22 infants born to HIV-1-infected women had hCG levels in excess of 90 IU/L, and 7 (88%) of these were shown to be HIV-infected. The remaining 14 infants born to HIV-1-infected women had low hCG levels, and 3 (21%) of the 14 had HIV infection. Mean follow-up time for HIV-uninfected infants was 17.5 months (range 9 months to 3 years). A statistically significant association between maternal-fetal HIV-1 transmission and hCG levels > or = 90 IU/L in cord sera was observed (p = 0.02). The difference between CD4 counts among mothers who transmitted HIV and those who did not was also statistically significant (p = 0.025). On the basis of this study's findings, we propose that cord blood hCG may serve as a surrogate marker for HIV-1 infection. Testing hCG levels in cord sera is an inexpensive and readily available screening test for early identification of infants at increased risk for getting HIV-1 from their mothers. 相似文献
6.
7.
Asmaa A. Zidan Mohammed Al-Hawwas Griffith B. Perkins Ghada M. Mourad Catherine J. M. Stapledon Larisa Bobrovskaya Xin-Fu Zhou Plinio R. Hurtado 《International journal of molecular sciences》2021,22(1)
Elucidation of the biological functions of extracellular vesicles (EVs) and their potential roles in physiological and pathological processes is an expanding field of research. In this study, we characterized USC–derived EVs and studied their capacity to modulate the human immune response in vitro. We found that the USC–derived EVs are a heterogeneous population, ranging in size from that of micro–vesicles (150 nm–1 μm) down to that of exosomes (60–150 nm). Regarding their immunomodulatory functions, we found that upon isolation, the EVs (60–150 nm) induced B cell proliferation and IgM antibody secretion. Analysis of the EV contents unexpectedly revealed the presence of BAFF, APRIL, IL–6, and CD40L, all known to play a central role in B cell stimulation, differentiation, and humoral immunity. In regard to their effect on T cell functions, they resembled the function of mesenchymal stem cell (MSC)–derived EVs previously described, suppressing T cell response to activation. The finding that USC–derived EVs transport a potent bioactive cargo opens the door to a novel therapeutic avenue for boosting B cell responses in immunodeficiency or cancer. 相似文献
8.
9.
为解决云制造模式下企业服务能力有限性及客户需求不确定性问题,深入分析云制造企业群多时序生产服务模式,基于服务时间、成本和质量构建差异化产品生产优化模型,结合客户需求的偏好性与模糊性,引入三角模糊及广义诱导有序加权平均算子针对客户模糊需求给出区间型组合供应算法,确定协同制造企业群的最优组合.以包含4类差异制造需求的产品为例,进行MATLAB仿真实验,验证了所提模型与算法的有效性与可行性.结果表明,差异化产品增强了云制造服务流程的复杂性,多时序生产可较好地分解与重组制造任务,嵌入客户模糊化需求,从而提高云制造服务平台的运作效率及应用效果. 相似文献
10.
FI Meredith RT Riley CW Bacon DE Williams DB Carlson 《Canadian Metallurgical Quarterly》1998,61(8):1034-1038
The purpose of this study was (i) to determine whether pure fumonisin B1 could be incorporated into, recovered, and detected by high-pressure liquid chromatographic analysis from the semipurified Oregon test diet (OTD) used in rainbow trout feeding studies, and (ii) to determine if the incorporated fumonisin B1 was biologically available using the change in free sphingoid bases in liver, kidney, and serum as a mechanism-based biomarker. The results indicate that fumonisin is not easily quantified in the OTD. Recoveries ranged from 12 to 81% of the calculated concentrations based on the fumonisin B1 added to the OTD. However, the fumonisin B1 in the OTD was readily absorbed and biologically active as evidenced by marked increases in free sphinganine in liver, kidney, and serum. The magnitude of the increase in free sphinganine at 100 ppm in the OTD was comparable to that known to be associated with liver toxicity in rats, pigs, and ponies. 相似文献