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排序方式: 共有4664条查询结果,搜索用时 15 毫秒
1.
Dr. Raysa Khan Tareque Dr. Storm Hassell-Hart Dr. Tobias Krojer Dr. Anthony Bradley Dr. Srikannathasan Velupillai Dr. Romain Talon Dr. Michael Fairhead Dr. Iain J. Day Kamlesh Bala Dr. Robert Felix Dr. Paul D. Kemmitt Prof. Paul Brennan Prof. Frank von Delft Dr. Laura Díaz Sáez Prof. Kilian Huber Prof. John Spencer 《ChemMedChem》2020,15(24):2513-2520
Combined photochemical arylation, “nuisance effect” (SNAr) reaction sequences have been employed in the design of small arrays for immediate deployment in medium-throughput X-ray protein–ligand structure determination. Reactions were deliberately allowed to run “out of control” in terms of selectivity; for example the ortho-arylation of 2-phenylpyridine gave five products resulting from mono- and bisarylations combined with SNAr processes. As a result, a number of crystallographic hits against NUDT7, a key peroxisomal CoA ester hydrolase, have been identified. 相似文献
2.
A high prevalence of epilepsy (up to 1.3%) was observed in an area hyperendemic for onchocerciasis in the province of Bururi, Burundi. Following this observation, epileptics and controls were examined in 2 communes (administrative units) with different endemicity for onchocerciasis. Altogether, onchocerciasis was more frequent in epileptics (81.8%) than in controls from the same households (68.3%; P < 0.05). This difference was more marked in the hyperendemic area. Other possible causes of epilepsy, including cysticercosis, were infrequent (18 possible cases among 110 epileptics). During this survey, 9 epileptics with growth retardation were seen. They showed most characteristics of Nakalanga syndrome, which was described from Uganda. All 9 such cases were suffering from onchocerciasis. These findings give more evidence of a possible association between onchocerciasis and epilepsy, and between onchocerciasis and Nakalanga syndrome. 相似文献
3.
芦笋保健搅拌酸奶的研制 总被引:8,自引:3,他引:5
芦笋是一种兼食品及较强保健功能的稀有蔬菜。对芦笋加工处理、发酵菌种选育驯化、辅料的选择、发酵工艺条件、搅拌方法等一系列的工艺探索,研制出色泽微翠绿、芦笋味典型并适合中老年消费者需求的保健型搅拌酸奶。 相似文献
4.
柏玉明 《湖南冶金职业技术学院学报》2003,(2)
信息技术是一种新型技术。信息技术和制造业相互依存、相互促进是一种发展趋势。信息技术对制造业的影响主要有:信息化在制造业的产品开发设计技术方面带来的进步,这主要包括计算机辅助技术;信息化在制造业的生产管理技术方面带来的进步,主要包括企业制造资源计划系统及产品数据管理;信息化在制造业的制造方式上带来的进步,主要包括柔性制造、计算机集成制造等先进制造技术。 相似文献
5.
槽孔式水力驱动控制棒槽孔阻力系数实验研究 总被引:2,自引:0,他引:2
对槽孔式水力驱动控制棒槽对孔阻力系数进行了大量实验研究,获得了槽孔式水力驱动控制棒槽对孔阻力系数和其随槽对孔位移的变化规律,分析了槽对孔阻力系数与控制棒槽对孔结构参数之间的关系。结果表明:随槽对孔位移的增加,槽对孔阻力系数从某一较大的定值迅速降低到某一较小的定值,然后再迅速反回到初始的定值,形成一个对称的宽幅波谷;槽高使阻力系数曲线波谷幅宽发生变化,也使完全不重合段的阻力系数发生变化;随内套孔径的增大,阻力系数有所降低,其对阻力系数的影响也进一步减弱。孔径增大到一定程度,阻力系数基本不受孔径参数的影响。 相似文献
6.
A Zemtsov GS Cameron CA Bradley V Montalvo-Lugo F Mattioli 《Canadian Metallurgical Quarterly》1994,308(6):365-369
Phosphocreatine molecules (PCR) in skin regenerate adenosine triphosphate and help cutaneous tissue survive ischemia associated with skin flaps, grafts, and hair transplantation procedures. In addition, PCR concentration in psoriasis is elevated many times above normal, indicating either overproduction of PCR by mitochondrial creatine phosphokinase (CPK) enzymes or a defect in cytosol CPK enzymatic activity. Skin CPK isoenzymes, before this study, have not been identified. Herein, for the first time, cytosol CPK enzymatic activity was measured in normal and psoriatic, involved and uninvolved skin, skin tumors, and mouse skin and keratinocyte cell cultures. Creatine phosphokinase MM is the major isoenzyme in normal, uninvolved psoriatic and mouse skin. Total CPK enzymatic activity was increased in psoriasis and skin tumors. These data clearly indicate that increased PCR concentration in a psoriatic skin is not a result of decreased cytosol CPK enzymatic activity. 相似文献
7.
8.
在对海洋进行考查时,需要了解声波在不同水域的的传播规律,这就要使用水下声源,在近距离的测试中可以用声呐系统,但声呐的传播距离有限,无法进行远距离测试,因此需要一种爆炸声源作为测试的手段,对水下爆炸声源进行了初步的探讨和研究. 相似文献
9.
The paper describes the development of a software design aid for use at the conceptual stage of engineering design. It is intended for use in the design of mechatronic products but has wider potential uses. Early approaches were based on function structures and tables of options and the system that evolved allows the assembly of schemes linked by matching their input and output ports. A database of components is provided which can be accessed via different indexes and the designer can easily create and compare alternative schemes at the concept stage.A bond graph approach is used to define the interconnections between components. This allows correct port matching but also provides for future development such as constraint propagation through the design and links to simulation tools. 相似文献
10.
P. Ravirajan S.A. Haque J.R. Durrant D.D.C. Bradley J. Nelson 《Advanced functional materials》2005,15(4):609-618
We report a study of the effects of polymer optoelectronic properties on the performance of photovoltaic devices consisting of nanocrystalline TiO2 and a conjugated polymer. Three different poly(2‐methoxy‐5‐(2′‐ethylhexoxy)‐1,4‐phenylenevinylene) (MEH‐PPV)‐based polymers and a fluorene–bithiophene copolymer are compared. We use photoluminescence quenching, time‐of‐flight mobility measurements, and optical spectroscopy to characterize the exciton‐transport, charge‐transport, and light‐harvesting properties, respectively, of the polymers, and correlate these material properties with photovoltaic‐device performance. We find that photocurrent is primarily limited by the photogeneration rate and by the quality of the interfaces, rather than by hole transport in the polymer. We have also studied the photovoltaic performance of these TiO2/polymer devices as a function of the fabrication route and device design. Including a dip‐coating step before spin‐coating the polymer leads to excellent polymer penetration into highly structured TiO2 networks, as was confirmed through transient optical measurements of the photoinduced charge‐transfer yield and recombination kinetics. Device performance is further improved for all material combinations studied, by introducing a layer of poly(ethylene dioxythiophene) (PEDOT) doped with poly(styrene sulfonic acid) (PSS) under the top contact. Optimized devices incorporating the additional dip‐coated and PEDOT:PSS layers produced a short‐circuit current density of about 1 mA cm–2, a fill factor of 0.50, and an open‐circuit voltage of 0.86 V under simulated AM 1.5 illumination (100 mW cm–2, 1 sun). The corresponding power conversion efficiency under 1 sun was ≥ 0.4 %. 相似文献