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排序方式: 共有492条查询结果,搜索用时 15 毫秒
1.
Dr. Raysa Khan Tareque Dr. Storm Hassell-Hart Dr. Tobias Krojer Dr. Anthony Bradley Dr. Srikannathasan Velupillai Dr. Romain Talon Dr. Michael Fairhead Dr. Iain J. Day Kamlesh Bala Dr. Robert Felix Dr. Paul D. Kemmitt Prof. Paul Brennan Prof. Frank von Delft Dr. Laura Díaz Sáez Prof. Kilian Huber Prof. John Spencer 《ChemMedChem》2020,15(24):2513-2520
Combined photochemical arylation, “nuisance effect” (SNAr) reaction sequences have been employed in the design of small arrays for immediate deployment in medium-throughput X-ray protein–ligand structure determination. Reactions were deliberately allowed to run “out of control” in terms of selectivity; for example the ortho-arylation of 2-phenylpyridine gave five products resulting from mono- and bisarylations combined with SNAr processes. As a result, a number of crystallographic hits against NUDT7, a key peroxisomal CoA ester hydrolase, have been identified. 相似文献
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Miloš Hašan Edgar Velázquez‐Armendáriz Fabio Pellacini Kavita Bala 《Computer Graphics Forum》2008,27(4):1105-1114
Rendering animations of scenes with deformable objects, camera motion, and complex illumination, including indirect lighting and arbitrary shading, is a long‐standing challenge. Prior work has shown that complex lighting can be accurately approximated by a large collection of point lights. In this formulation, rendering of animation sequences becomes the problem of efficiently shading many surface samples from many lights across several frames. This paper presents a tensor formulation of the animated many‐light problem, where each element of the tensor expresses the contribution of one light to one pixel in one frame. We sparsely sample rows and columns of the tensor, and introduce a clustering algorithm to select a small number of representative lights to efficiently approximate the animation. Our algorithm achieves efficiency by reusing representatives across frames, while minimizing temporal flicker. We demonstrate our algorithm in a variety of scenes that include deformable objects, complex illumination and arbitrary shading and show that a surprisingly small number of representative lights is sufficient for high quality rendering. We believe out algorithm will find practical use in applications that require fast previews of complex animation. 相似文献
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Agustinus Borgy Waluyo David Taniar Wenny Rahayu Bala Srinivasan 《Journal of Network and Computer Applications》2009,32(2):434-447
The ever-increasing number of mobile device users has also raised the users’ expectation of mobile services accordingly. This phenomenon has given pressures to the mobile service providers to improve their services in order to stay competitive in the market. The service oriented approach is seen to be a promising scheme for mobile services. This paper presents mobile service oriented architectures for Nearest-Neighbor (NN) queries that are classified into five categories, namely (i) intermittent query mobile services, (ii) continuous query mobile services, (iii) context-aware mobile services, (iv) continuous moving object query mobile services, and (v) data broadcast mobile services. These services incorporate query, location and context-aware services, ontological context model, and broadcast. The proposed architectures are concerned with mobile services for clients on the move requesting services based on their current location, which is arguably the most important feature in a wireless environment. Furthermore, we also discuss the Quality-of-Service (QoS) requirement for mobile services in which request latency time is one of the most important parameters to consider. Some analytical models for query latency measurement are presented and the results are compared with the simulation experiments. 相似文献
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The Journal of Supercomputing - Blockchain technology with its inherent security features revolutionizes the field of distributed networks and has become one of the significant areas of research.... 相似文献
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I. Garcia-Herrero J. Laso M. Margallo A. Bala C. Gazulla P. Fullana-i-Palmer I. Vázquez-Rowe A. Irabien R. Aldaco 《Clean Technologies and Environmental Policy》2017,19(7):1897-1912
Life cycle assessment (LCA) is a powerful tool to support environmental informed decisions among product and process alternatives. LCA results reflect the process stage contributions to several environmental impacts, which should be made mutually comparable to help in the decision-making process. Aggregated environmental indexes enable the translation of this set of metrics into a one final score, by defining the attached weights to impacts. Weighting values reflect the corresponding relevance assigned to each environmental impact. Current weighing schemes are based on pre-articulation of preferences, without considering the specific features of the system under study. This paper presents a methodology that combines LCA methodology and linear programming optimisation to determine the environmental improvement actions that conduct to a more sustainable production. LCA was applied using the environmental sustainability assessment methodology to obtain two main indexes: natural resources (NR) and environmental burdens (EB). Normalised indexes were optimised to determine the optimal joint of weighting factors that lead to an optimised global Environmental Sustainability Index. The proposed methodology was applied to a food sector, in particular, to the anchovy canning industry in Cantabria Region (Northern Spain). By maximising the objective function composed of NR and EB variables, it is possible to find the optimal joint of weights that identify the best environmental sustainable options. This study proves that LCA can be applied in combination with linear programing tools as a part of the decision-making process in the development of more sustainable processes and products. 相似文献
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Constitutive relations and field equations have been extended for a porous medium composed of two solids and containing two chemically non-reactive immiscible fluids. By generalizing the closure relation of porosity change and employing this into the mass balance equations, the stress–strain relations have been developed. The idea of generalized compressibility tests is invoked to find the value of dimensionless parameters appearing in the closure relation of porosity change. By generalizing momentum balance equations of Lo et al. (Water Resour Res 41:1–20, 2005), the propagation of dilatational and rotational waves is explored. It is found that four dilatational and two rotational waves exist in the porous medium. In contrast to Biot’s theory, the presence of the second fluid and second solid in the porous medium gives rise to additional P- and S-waves. Variation of phase speeds and corresponding attenuation coefficients of existing waves versus frequency, saturation of the fluid phases and solid fraction are computed numerically and depicted graphically. 相似文献
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Information Systems and e-Business Management - Collaborative filtering (CF) is a popular and widely accepted recommendation technique. CF is an automated form of word-of-mouth communication... 相似文献