Exterior stable domain segmentation integral equation method for scattering problems

This paper is concerned with the development of an exterior domain segmentation method for the solution of two- or three-dimensional time-harmonic scattering problems in acoustic media. This method, based on a variational localized, symmetric, boundary integral equation formulation leads, upon discretization, to a sparse system of algebraic equations whose solution requires only O(N) multiplications, where N is the number of unknown nodal pressures on the scatterer surface. The new procedure is analogous to the one developed recently¹ except that in the present formulation we avoid completely the use of the hypersingular operator, thereby reducing the computational complexity. Numerical experiments for a rigid circular cylindrical scatterer subjected to a plane incident wave serve to assess its accuracy for normalized wave numbers, ka, ranging from 0 to 30, both directly on the scatterer and in the far field, and to confirm that, contrary to standard boundary integral equation formulations, the present procedure is valid for critical frequencies.     

A finite element scheme with a high order absorbing boundary condition for elastodynamics

A high-order absorbing boundary condition (ABC) is devised on an artificial boundary for time-dependent elastic waves in unbounded domains. The configuration considered is that of a two-dimensional elastic waveguide. In the exterior domain, the unbounded elastic medium is assumed to be isotropic and homogeneous. The proposed ABC is an extension of the Hagstrom–Warburton ABC which was originally designed for acoustic waves, and is applied directly to the displacement field. The order of the ABC determines its accuracy and can be chosen to be arbitrarily high. The initial boundary value problem including this ABC is written in second-order form, which is convenient for geophysical finite element (FE) analysis. A special variational formulation is constructed which incorporates the ABC. A standard FE discretization is used in space, and a Newmark-type scheme is used for time-stepping. A long-time instability is observed, but simple means are shown to dramatically postpone its onset so as to make it harmless during the simulation time of interest. Numerical experiments demonstrate the performance of the scheme.     

Intraindividual variability is related to cognitive change in older adults: Evidence for within-person coupling.

In this study, the authors addressed the longitudinal nature of intraindividual variability over 3 years. A sample of 304 community-dwelling older adults, initially between the ages of 64 and 92 years, completed 4 waves of annual testing on a battery of accuracy- and latency-based tests covering a wide range of cognitive complexity. Increases in response-time inconsistency on moderately and highly complex tasks were associated with increasing age, but there were significant individual differences in change across the entire sample. The time-varying covariation between cognition and inconsistency was significant across the 1-year intervals and remained stable across both time and age. On occasions when intraindividual variability was high, participants' cognitive performance was correspondingly low. The strength of the coupling relationship was greater for more fluid cognitive domains such as memory, reasoning, and processing speed than for more crystallized domains such as verbal ability. Variability based on moderately and highly complex tasks provided the strongest prediction. These results suggest that intraindividual variability is highly sensitive to even subtle changes in cognitive ability. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Successful coping with declining objective life style by institutionalized long-term patients. Results of a follow-up analysis of quality of life in long-term care institutions with the Zurich Quality of Life Inventory

Folding of cytochrome c from its low pH guanidine hydrochloride (Gdn-HCl) denatured state revealed a new intermediate, a five-coordinate high spin species with a water molecule coordinated to the heme. Incorporation of this five-coordinated intermediate into the previously reported ligand exchange model can quantitatively account for the observed folding kinetics. In this new model, unfolded cytochrome c is converted to its native structure through an obligatory folding intermediate, the histidine-water coordination state, whereas the five-coordinate state and a bis-histidine state are off-pathway intermediates. When the concentration of Gdn-HCl in the refolding solution was increased, an acceleration of the conversion from the bis-histidine coordinated state to the histidine-water coordinated state was observed, demonstrating that the reaction requires unfolding of the mis-organized polypeptide structure associated with the bis-histidine state.     

Variations in methane yield and microbial community profiles in the rumen of dairy cows as they pass through stages of first lactation

Considerable interest exists both from an environmental and economic perspective in reducing methane emissions from agriculture. In ruminants, CH₄ is produced by a complex community of microorganisms that is established in early life but can be influenced by external factors such as feed. Although CH₄ emissions were thought to be constant once an animal reached maturity, recent studies have shown that CH₄ yield significantly increases from early to late lactation in dairy cows. The aim of this study was to test the hypothesis that increases in CH₄ yield over the lactation cycle are related to changes in rumen microbial community structure. Nine cows were monitored throughout their first lactation cycle. Methane and dry matter intake were measured to calculate CH₄ per dry matter intake (CH₄ yield) and ruminal fluid was collected during early, mid, and late lactation. A significant difference in bacterial and archaeal community structure during early and late lactation was observed. Furthermore, when ruminal short-chain fatty acid concentrations were measured, the ratio of acetate and butyrate to propionate was significantly higher in late lactation compared with early lactation. Propionate concentrations were higher in cows with low CH₄ yield during late lactation, but no differences were observed in bacterial or archaeal community structures. Prevotella dominated the rumen of cows followed by Succinclasticum; Treponema, Fibrobacter, Ruminococcus, and Bifidobacterium were also in high abundance relative to other bacterial genera. In general, positive correlations were stronger between the most relatively abundant bacterial genera and acetate and butyrate concentrations in the cows with high CH₄ and weaker between these genera and propionate concentration. This study indicates that increased CH₄ yield in late lactation is reflected in significant changes in microbial community structure.     

Intraindividual variability in reaction time predicts cognitive outcomes 5 years later.

Objective: Building on results suggesting that intraindividual variability in reaction time (inconsistency) is highly sensitive to even subtle changes in cognitive ability, this study addressed the capacity of inconsistency to predict change in cognitive status (i.e., cognitive impairment, no dementia [CIND] classification) and attrition 5 years later. Method: Two hundred twelve community-dwelling older adults, initially aged 64–92 years, remained in the study after 5 years. Inconsistency was calculated from baseline reaction time performance. Participants were assigned to groups on the basis of their fluctuations in CIND classification over time. Logistic and Cox regressions were used. Results: Baseline inconsistency significantly distinguished among those who remained or transitioned into CIND over the 5 years and those who were consistently intact (e.g., stable intact vs. stable CIND, Wald (1) = 7.91, p     

Improving size estimates using historical data

A software project's estimate of effort commonly requires input specifying the project size, and a reliable size estimate depends on many factors. This study examines a completed C++ project and considers programming artifacts that we can readily trace to requirements and early class design     

Virtual topography: A fictitious domain approach for analyzing free‐surface irregularities in large‐scale earthquake ground motion simulation

This paper presents a numerical scheme based on a fictitious domain framework for the numerical modeling of earthquake‐induced ground motion in the presence of realistic surface topography of the Earth's crust. We show that by adopting a non‐conforming octree‐based meshing approach associated with a virtual representation of the surficial irregularity, we can obtain accurate representations of ground motion. From the computational point of view, our methodology proves to be also efficient, and more importantly, it allows us to preserve the salient features of multi‐resolution cubic‐shaped finite elements for wave propagation applications. We implemented the non‐conforming meshing scheme for the treatment of realistic topographies into Hercules, the octree‐based finite‐element earthquake simulator developed by the Quake Group at Carnegie Mellon University. We tested the benefits of the strategy by benchmarking its results against reference examples, and by means of numerical error estimate analyses. Our qualitative and quantitative comparisons showed a close agreement between our numerical results and the reference results, and also, that the order of convergence of the displacement field is preserved in the presence of surface topography. Moreover, this performance was obtained by using the same mesh refinement techniques with cubic elements as in traditional flat free‐surface simulations. Copyright © 2014 John Wiley & Sons, Ltd.     

Sea-water desalination with nuclear and other energy sources: the EURODESAL project

This paper summarises our recent investigations undertaken as part of the EURODESAL project on nuclear desalination, currently being carried out by a consortium of four European, and one Canadian, industrials and two leading EU R&D organisations.Major achievements of the project, as discussed in this paper are:

• Coherent demonstration of the technical feasibility of nuclear desalination through the elaboration of coupling schemes for optimum cogeneration of electricity and water and by exploring the unique capabilities of the innovative nuclear reactors and desalination technologies.

• Verification that the integrated system design does not adversely affect nuclear reactor safety.

• Development of codes and methods for an objective economic assessment of the competitiveness and sustainability of proposed options through comparison, in European conditions, with fossil energy based systems.

Results obtained so far seem to be quite encouraging as regards the economical viability of nuclear desalination options.Thus, for example, specific desalination costs ($/m³ of desalted water) for nuclear systems, such as the AP-600 and the French PWR-900 (reference base case), coupled to multiple effect distillation (MED) or the reverse osmosis (RO) processes, are 30–60% lower than the desalination costs for fossil energy based systems, using pulverised coal and natural gas with combined cycle, at low discount rates and recommended fossil fuel prices. Even in the most unfavourable scenarios for nuclear energy (discount rate=10%, low fossil fuel costs) desalination costs with the nuclear reactors are 7–20% lower, depending upon the desalination capacities. Furthermore, with the advanced coupling schemes, utilising waste heat from nuclear reactors, the gains in specific desalination costs of nuclear systems are increased by another 2–15%, even without system and design optimisation. A preliminary evaluation shows that desalination costs with the GT-MHR, coupled to a MED process, could still be much lower than the above nuclear options for desalting capacities≤43 000 m³ per day. This is because its design intrinsically provides “virtually free” heat at ideal temperatures for desalination (80–100 °C).