The decorative coloring of glassware by UV irradiation

Glass and Ceramics -     

Silver Atomic Quantum Clusters of Three Atoms for Cancer Therapy: Targeting Chromatin Compaction to Increase the Therapeutic Index of Chemotherapy

Nanomaterials with very low atomicity deserve consideration as potential pharmacological agents owing to their very small size and to their properties that can be precisely tuned with minor modifications to their size. Here, it is shown that silver clusters of three atoms (Ag₃‐AQCs)—developed by an ad hoc method—augment chromatin accessibility. This effect only occurs during DNA replication. Coadministration of Ag₃‐AQCs increases the cytotoxic effect of DNA‐acting drugs on human lung carcinoma cells. In mice with orthotopic lung tumors, the coadministration of Ag₃‐AQCs increases the amount of cisplatin (CDDP) bound to the tumor DNA by fivefold without modifying CDDP levels in normal tissues. As a result, CDDP coadministered with Ag₃‐AQCs more strongly reduces the tumor burden. Evidence of the significance of targeting chromatin compaction to increase the therapeutic index of chemotherapy is now provided.     

Little science confronts the data deluge: habitat ecology, embedded sensor networks, and digital libraries

e-Science promises to increase the pace of science via fast, distributed access to computational resources, analytical tools, and digital libraries. “Big science” fields such as physics and astronomy that collaborate around expensive instrumentation have constructed shared digital libraries to manage their data and documents, while “little science” research areas that gather data through hand-crafted fieldwork continue to manage their data locally. As habitat ecology researchers begin to deploy embedded sensor networks, they are confronting an array of challenges in capturing, organizing, and managing large amounts of data. The scientists and their partners in computer science and engineering make use of common datasets but interpret the data differently. Studies of this field in transition offer insights into the role of digital libraries in e-Science, how data practices evolve as science becomes more instrumented, and how scientists, computer scientists, and engineers collaborate around data. Among the lessons learned are that data on the same variables are gathered by multiple means, that data exist in many states and in many places, and that publication practices often drive data collection practices. Data sharing is embraced in principle but little sharing actually occurs, due to interrelated factors such as lack of demand, lack of standards, and concerns about publication, ownership, data quality, and ethics. We explore the implications of these findings for data policy and digital library architecture. Research reported here is affiliated with the Center for Embedded Networked Sensing.