An examination of differences between native and non-native psychiatric offenders on the MMPI.

Compared Minnesota Multiphasic Personality Inventory (MMPI) scores of 57 native and 218 non-native Canadian Prairie psychiatric offenders. All Ss were adult males. In uncontrolled comparisons, considerable cross-cultural profile similarity was observed. Separate native and non-native multiple regressions were performed, using the 13 MMPI scales as criterion variables with age, time served, education level, Wechsler Adult Intelligence Scale (WAIS) Full Scale IQ, and Verbal Comprehension as the predictors. WAIS Full Scale IQ and education level were the strongest predictors of native and non-native MMPIs, respectively. When controlled MMPI comparisons were made using IQ and education as covariates, the previous differences were erased. With covariates, significantly lower native scores were found on Mf, Pa, and Si, while K was significantly higher. The lowered native profile was due primarily to the IQ covariate. (French abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Endogenous prostaglandin E2 mediates inhibition of rat thick ascending limb Cl reabsorption in chronic hypercalcemia

The hypothesis that endogenous PGE2 mediates defective thick ascending limb (TAL) Cl reabsorption (percent delivered load: FRCl%) in rats with vitamin D-induced chronic hypercalcemia (HC) was tested by measuring FRCl% in loop segments microperfused in vivo in HC and control rats treated acutely with indomethacin (Indo) or its vehicle, and obtaining the corresponding outer medullary [PGE2]. Microperfusion conditions were developed in which FRCl% was exclusively furosemide sensitive. To determine the cellular mechanism, tubules were perfused acutely with forskolin (FSK), cAMP, or the protein kinase C inhibitor staurosporine (SSP). Outer medullary [PGE2] in HC rats was 9 to 10 times greater than control and could be normalized by Indo. FRCl% was 20% lower in HC rats infused with vehicle, and Indo, FSK, and cAMP returned FRCl% to normal despite sustained HC. Indo or FSK had no effect on FRCl% in control rats and Indo did not prevent inhibition of FRCl% by luminal PGE2 (1 microM). Luminal SSP (10(-7), 10(-8) M) in HC did not return FRCl% to control values. We conclude that impaired TAL FRCl% in HC occurs at a pre-cAMP site and is due to endogenous PGE2 and not to HC.