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排序方式: 共有178条查询结果,搜索用时 15 毫秒
1.
Gong S.S. Burnham M.E. Theodore N.D. Schroder D.K. 《Electron Devices, IEEE Transactions on》1993,40(7):1251-1257
Electrical time-to-breakdown (TTB) measurements have shown the charge to breakdown Q bd of gate oxide capacitors fabricated on n-type well (n-well) substrates always to be higher than that of capacitors on p-type well (p-well) substrates on the same wafer when both are biased into accumulation under normal test conditions. Here the authors correlate the higher n-well Q bd to smooth capacitor oxide/substrate interfaces and minimized grain boundary cusps at the poly-Si gate/oxide interfaces, confirming that Fowler-Nordheim tunneling is the dominant current conduction mechanisms through the oxide. They correlate higher Q bd to higher barrier height for a given substrate type and observe that the slope of the barrier height versus temperature plot is lower for both p-well and n-well cases with electrons tunneling from the silicon substrate. This is attributed to surface roughness at the poly-Si gate/SiO2 interface. A poly-Si gate deposition and annealing process with clean, smooth oxide/substrate interfaces will improve the p-well breakdown characteristics and allow higher Q bd to be achieved 相似文献
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G. L. Brownell C. A. Burnham C. W. Stearns D. A. Chesler A.-L. Brownell M. R. Palmer 《International journal of imaging systems and technology》1989,1(2):207-217
The development of high resolution PET systems is important for the wider application of this techniques. The resolution of PET is limited by a number of physical factors such as positron range, small angle deviation, and sampling frequency. The design of the detector array and its sensitivity remain critical factors; designs incorporating analog coding have proven to be useful. PCR-I, a single plane PET system, has demonstrated the concept and has produced useful images in animal studies. PCR-II will extend the concept to a two dimensional detector array resulting in a system with high resolution and high sensitivity. 相似文献
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Aromaticities determined by 13C n.m.r. are reported for five shale oil samples (Green River formation) prepared under widely different pyrolysis conditions. In the absence of high-pressure hydrogen, the total amount of aromatic carbon in the products is nearly twice that in the raw shale. This is true for a wide range of pyrolysis conditions, although the distribution of aromatic carbon between the oil and carbonaceous residue changes. High-pressure hydrogen appears to inhibit both the formation of additional aromatic carbon during pyrolysis and the coking of aromatic oil. An improved kerogen decomposition mechanism is reported that accounts for these effects and provides for changes in the aromaticity of the liquid product with pyrolysis conditions. Further work is necessary to make it quantitative and account for gas formation. 相似文献
6.
A standard acute toxicity study was undertaken to assess 2'-deoxyribonucleoside cyanoboranes for therapeutic safety. 2'-Deoxyribonucleoside cyanoboranes and related derivatives were nontoxic at doses required for anti-neoplastic and hypolipidemic activities. At higher doses (50 and 100 mg/kg/day IP for 7 days), all treated animals survived with slight reductions in total body weight and small decrements in daily food consumption. No clinical chemistry value was elevated to a magnitude suggesting onset of organ specific toxicity. However, agents appeared to modulate subpopulations of white blood cells, i.e., more lymphocytes than PMNs were present in blood from treated animals as determined by differential cell counts. This modulation is correlated with increases in granulomatous foci in the spleen and mesentery of treated animals after 7 days. The kidney was damaged only by Compound 5 at 50 and 100 mg/kg/day; Compound 5 had the most potent anti-neoplastic activity. The compounds demonstrated no in vitro toxicity against human HCT-8 ileum cells. LD(50) values were greater than 1000 mg/kg, IP, for all compounds. 相似文献
7.
Acyclic amine-carboxyboranes were effective anti-inflammatory agents in mice at 8 mg/kg x 2. These amine-carboxyboranes were more effective than the standard indomethacin at 8 mg/kg x 2, pentoxifylline at 50 mg/kg x 2, and phenylbutazone at 50 mg/kg x 2. The heterocyclic amine derivatives as well as amine-carbamoylboranes, carboalkoxyboranes, and cyanoboranes were generally less active. However, selected aminomethyl-phosphonate-N-cyanoboranes demonstrated greater than 60% reduction of induced inflammation. The boron compounds were also active in the rat induced edema, chronic arthritis, and pleurisy screens, demonstrating activity similar to the standard indomethacin. The compounds were effecive in reducing local pain and decreased the tail flick reflex to pain. The derivatives which demonstrated good anti-inflammatory activity were effective inhibitors of hydrolytic lysosomal, and proteolytic enzyme activities with IC(50) 50 values equal to (-6)M in mouse macrophages, human leukocytes, and Be Sal osteofibrolytic cells. In these same cell lines, the agents blocked prostaglandin cyclooxygenase activity with IC(50) values of (-6)M. In mouse macrophage and human leukocytes, 5' lipoxygenase activity was also inhibited by the boron derivatives with IC(50) values of 10(-6)M. These IC(50) values for inhibition of these enzyme activities are consistent with published values of known anti-inflammatory agents which target these enzymes. 相似文献
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Double-heterostructure (DH) diode lasers with a thin Ga1-x Alx As layer between the active GaAs region and the GaAs substrate or superstrate are analyzed. In these devices power flows through the thin Ga1-x Alx As layer and is radiated into the substrate or superstrate. Three methods for computing the laser thresholds are developed and compared. The first is an analytic perturbation technique, which yields accurate results in many cases of practical interest. The second and third are rapidly convergent numerical iteration techniques. The former utilizes overlap integrals to compute absorption losses and thresholds; the latter includes all losses and gains directly in the formulation. We show that conventional DH diode lasers can be designed with thick active GaAs layers and still achieve lowest order TE-mode operation. These devices will produce better collimated, higher power output beams than do similar devices with thinner active regions. Transverse-mode control is achieved because all higher order modes have increased penetration through the thin Ga1-x Alx As , and therefore exhibit inereased radiation losses into the substrate or superstrate. A design example is included in which it is shown that with proper choice of the Ga1-x Alx As-layer thickness the TE0 -mode threshold increases by 5 percent compared with a 110-percent increase in the TE1 threshold. These results are virtually independent of the substrate power-absorption coefficient. Threshold current densities are computed for a set of diodes studied experimentally by Casey and Panish and the results are shown to be in excellent agreement. 相似文献
10.
HD Kalter M Hossain G Burnham NZ Khan SK Saha MA Ali RE Black 《Canadian Metallurgical Quarterly》1999,13(1):99-113
The objective of this study was to validate retrospective caregiver interviews for diagnosing major causes of severe neonatal illness and death. A convenience sample of 149 infants aged < 28 days with one or more suspected diagnoses of interest (low birthweight/severe malnutrition, preterm birth, birth asphyxia, birth trauma, neonatal tetanus, pneumonia, meningitis, septicaemia, diarrhoea, congenital malformation or injury) was taken from patients admitted to two hospitals in Dhaka, Bangladesh. Study paediatricians performed a standardised history and physical examination and ordered laboratory and radiographic tests according to study criteria. With a median interval of 64.5 days after death or hospital discharge, caregivers of 118 (79%) infants were interviewed about their child's illness. Using reference diagnoses based on predefined clinical and laboratory criteria, the sensitivity and specificity of particular combinations of signs (algorithms) reported by the caregivers were ascertained. Sufficient numbers of children with five reference standard diagnoses were studied to validate caregiver reports. Algorithms with sensitivity and specificity > 80% were identified for neonatal tetanus, low birthweight/severe malnutrition and preterm delivery. Algorithms with specificities > 80% for birth asphyxia and pneumonia had sensitivities < 70%, or alternatively had high sensitivity with lower specificity. In settings with limited access to medical care, retrospective caregiver interviews provide a valid means of diagnosing several of the most common causes of severe neonatal illness and death. 相似文献