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Latent or sub-clinical hepatic encephalopathy is a recognized complication of cirrhosis and is thought to represent one end of the spectrum of neuropsychiatric impairment, which occurrs as a result of portal-systemic shunting. We studied the psychometric, analyzed electroencephalography (EEG), and venous blood ammonia responses to an oral glutamine challenge in 17 patients with cirrhosis and in 4 normal controls. The cirrhotics were attending for liver transplant assessment and had no clinical evidence of hepatic encephalopathy. The oral glutamine challenge was repeated following liver transplantation. Five of sixteen patients (31%) showed impaired performance on at least one of the baseline psychometric tests. There was a correlation between fasting venous ammonia and choice reaction time (r = .7, P < .01). Following glutamine challenge there was a significant increase in blood ammonia from a mean fasting value ranging between 58 micromol/L to 120 micromol/L (P < .01), between significant prolongation of reaction times of 387 ms to 428 ms (P < .01), and an increase in mean EEG amplitude between 68.5 microV to 78.6 microV (P < .001). Four normal controls who were challenged with glutamine and 6 cirrhotic patients who were challenged with water showed no change in any of these parameters. Following orthotopic liver transplantation (OLT) the eight patients studied had normal baseline psychomotor performance with significant improvements in digit symbol, digit span, information processing, number connection tests (P < .05), and reaction time (P < .005). Posttransplantation, there were no significant changes in blood ammonia, analyzed EEG, or choice reaction time in response to oral glutamine challenge (six patients). We conclude that short lived changes in blood ammonia (in cirrhotics) can cause significant impairment of sensitive tests of brain function and that psychometric performance is improved following OLT. 相似文献
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WJ Cho EK Kim MJ Park SU Choi CO Lee SH Cheon BG Choi BH Chung 《Canadian Metallurgical Quarterly》1998,6(12):2449-2458
In this study a series of 3-arylisoquinoline derivatives were synthesized and cytotoxicity against human melanoma tumor cell evaluated, and a three dimensional quantitative structure-activity relationship was investigated using the comparative molecular field analysis (CoMFA). The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinolines were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.721) was obtained through CoMFA. 相似文献
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本文分析空压机原联动控制系统的运行特点,对系统进行改造,利用自制电子式两位差动可调控制器取代压力控制器,克服原系统的缺陷。达到了改造的目的。 相似文献
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CO Dummett 《Canadian Metallurgical Quarterly》1996,88(7):454-459
In existence for more than 100 years, the schools of medicine and dentistry of Howard University and Meharry Medical College have been responsible for training the majority of African-American physicians and dentists. The dissolution of the doctrine of "separate but equal" has resulted in the acceptance of larger numbers of African-American health professionals to America's medical and dental educational institutions. The University of Tennessee School of Dentistry is a primary example of a formerly segregated institution that has changed its policies and presently possesses a respectable number of African-American dental alumni. In a recent acknowledgment of this fact on Alumni Day, black graduates of this University celebrated and sponsored a program to increase the number of African-American matriculants at the school. 相似文献
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国内外通用型金属封闭开关设备技术动态(一) 总被引:1,自引:0,他引:1
本文介绍通用型金属封闭关设备的国内外总本技术水平,目前产品的结构与特点,国内 自行设计和引进技术以及今后产品发展的前景。 相似文献