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WJ Cho EK Kim MJ Park SU Choi CO Lee SH Cheon BG Choi BH Chung 《Canadian Metallurgical Quarterly》1998,6(12):2449-2458
In this study a series of 3-arylisoquinoline derivatives were synthesized and cytotoxicity against human melanoma tumor cell evaluated, and a three dimensional quantitative structure-activity relationship was investigated using the comparative molecular field analysis (CoMFA). The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinolines were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.721) was obtained through CoMFA. 相似文献
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CO Dummett 《Canadian Metallurgical Quarterly》1996,88(7):454-459
In existence for more than 100 years, the schools of medicine and dentistry of Howard University and Meharry Medical College have been responsible for training the majority of African-American physicians and dentists. The dissolution of the doctrine of "separate but equal" has resulted in the acceptance of larger numbers of African-American health professionals to America's medical and dental educational institutions. The University of Tennessee School of Dentistry is a primary example of a formerly segregated institution that has changed its policies and presently possesses a respectable number of African-American dental alumni. In a recent acknowledgment of this fact on Alumni Day, black graduates of this University celebrated and sponsored a program to increase the number of African-American matriculants at the school. 相似文献
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国内外通用型金属封闭开关设备技术动态(一) 总被引:1,自引:0,他引:1
本文介绍通用型金属封闭关设备的国内外总本技术水平,目前产品的结构与特点,国内 自行设计和引进技术以及今后产品发展的前景。 相似文献
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LED照明亮度控制新技术特征与应用 总被引:1,自引:0,他引:1
随着LED应用的不断增加,大功率LED的驱动控制日显重要。本文分析介绍了LED照明亮度控制的新技术特征与应用。 相似文献
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该文对微机械气流式水平姿态传感器敏感机理进行了三维的有限元分析.利用ANSYS-FLOTRAN CFD软件,通过建模、划分网格、加载和求解等途径,计算了微机械气流式水平姿态传感器敏感元件密闭腔体中气流速度在不同倾斜状态下的分布.阐明微机械气流式水平姿态传感器的敏感机理,为气流式水平姿态传感器的优化设计开辟了更精确的研究途径. 相似文献
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ID Kurzman EG MacEwen RC Rosenthal LE Fox ET Keller SC Helfand DM Vail RR Dubielzig BR Madewell CO Rodriguez 《Canadian Metallurgical Quarterly》1995,1(12):1595-1601
Two randomized, double-blind clinical trials in dogs with spontaneous appendicular osteosarcoma treated with combination chemoimmunotherapy are reported. In both trials, dogs without overt metastasis underwent complete amputation of the affected limb. In trial 1, 40 dogs were treated with cisplatin chemotherapy [(CDDP), 70 mg/m2 i.v. every 28 days x 4]. Following CDDP, dogs without evidence of overt metastasis (n = 25) were randomized to receive liposome-encapsulated muramyl tripeptide phosphatidylethanolamine ](L-MTP-PE), 2 mg/m2 i.v.) or placebo liposomes (lipid equivalent) twice weekly for 8 weeks. Of 14 dogs in the placebo group, 13 (93%) died of metastasis; the median survival time was 9.8 months. Of 11 dogs in the L-MTP-PE group, 8 (73%) developed metastasis; the median survival time was 14.4 months, which was significantly longer than that of the placebo group (P < 0.01). In trial 2, 64 dogs received CDDP (70 mg/m2 i.v. every 21 days x 4) and were randomized to concurrently receive L-MTP-PE (2 mg/m2 i.v.) twice or once weekly, or placebo liposomes once weekly for 8 weeks. Median survival times were 10.3, 10.5, and 7.6 months, respectively. There were no significant differences among the three treatment groups in trial 2. Survival times for dogs receiving L-MTP-PE in trial 1 were significantly longer than those for dogs in trial 2 that received four doses of CDDP concurrently with twice weekly L-MTP-PE (P < 0. 04). The results of the first trial confirm our previous observation that L-MTP-PE has antimetastatic activity in dogs with osteosarcoma when given following amputation. The results of the second trial demonstrate that there is no survival advantage of administering L-MTP-PE concurrently with CDDP. 相似文献
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Zhang Haicun Liu Mingxia Liu Daoxin Guo Wenyong Zhi Jinhua Zhou Yafeng Xi’an Shaangu Power CO. LTD Xi’an China 《稀有金属材料与工程》2012,(Z1):78-80
0Cr17Ni4Cu4Nb powder was used to investigate the same-stuff laser repair(LR)technology on the semishrounded impeller.To improve the repaired effect,heat treatment was used after LR forming process.By means of optical microscopy,scan electron microscopy(SEM),micro-hardness tester and tensile tests,the microstructure of the coating was investigated and mechanical properties were measured.The experimental results show that cladding layer is well bonded to the substrate,the microstructure of the laser repaired zone(LRZ)is coarse martensite which will be refined after heat-treatment.The mechanical property experiments indicate that the micro-hardness and toughness would be increased after heat-treatment,the strength of LRZ after heat-treatment is 1050~1200 MPa,while the strength of normal laser repaired sample is 1000~1050 MPa.The refinement effect due to the heat treatment plays an important role in the improvement of the mechanical properties of samples.Overspeed examination and the real operation of the impeller after repairing also confirmed the reliability of this same-stuff and equal-strength laser cladding technology. 相似文献
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