In Vivo Albumin-Binding of a C-Functionalized Cyclam Platform for 64Cu-PET/CT Imaging in Breast Cancer Model

An improved glucose-chelator-albumin bioconjugate (GluCAB) derivative, GluCAB-2^Mal, has been synthesized and studied for in vivo ⁶⁴Cu-PET/CT imaging in breast cancer mice models together with its first-generation analogue GluCAB-1^Mal. The radioligand works on the principle of tumor targeting through the enhanced permeability and retention (EPR) effect with a supportive role played by glucose metabolism. [⁶⁴Cu]Cu-GluCAB-2^Mal (99 % RCP) exhibited high serum stability with immediate binding to serum proteins. In vivo experiments for comparison between tumor targeting of [⁶⁴Cu]Cu-GluCAB-2^Mal and previous-generation [⁶⁴Cu]Cu-GluCAB-1^Mal encompassed microPET/CT imaging and biodistribution analysis in an allograft E0771 breast cancer mouse model. Tumor uptake of [⁶⁴Cu]Cu-GluCAB-2^Mal was clearly evident with twice as much accumulation as compared to its predecessor and a tumor/muscle ratio of up to 5 after 24 h. Further comparison indicated a decrease in liver accumulation for [⁶⁴Cu]Cu-Glu-CAB-2^Mal.     

The dimensions underlying perceived attitudes: Liberalism and concern for traditional values.

Two studies identified and labeled the dimensions that people use to judge others' attitudes. In the 1st study, 50 male and 50 female undergraduates viewed pairs of attitude statements drawn from 1 or 2 large sets. For each pair of statements, Ss judged whether or not a person who agreed with one statement in the pair would be likely to agree with the other. The dimensions of liberalism and traditional values were found to underlie perceived attitudes. Validity was confirmed in a 2nd study with 60 male and 60 female undergraduates who rated the characteristics of hypothetical people who agreed strongly with particular statements. Results suggest that there is a common structure to people's perceptions of others' attitudes. (French abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Imaging of near-Earth space plasma

This paper describes the technique of imaging the ionosphere using tomographic principles. It reports on current developments and speculates on the future of this research area. Recent developments in computing and ionospheric measurement, together with the sharing of data via the internet, now allow us to envisage a time when high-resolution, real-time images and 'movies' of the ionosphere will be possible for radio communications planning. There is great potential to use such images for improving our understanding of the physical processes controlling the behaviour of the ionosphere. While real-time images and movies of the electron concentration are now almost possible, forecasting of ionospheric morphology is still in its early stages. It has become clear that the ionosphere cannot be considered as a system in isolation, and consequently new research projects to link together models of the solar-terrestrial system, including the Sun, solar wind, magnetosphere, ionosphere and thermosphere, are now being proposed. The prospect is now on the horizon of assimilating data from the entire solar-terrestrial system to produce a real-time computer model and 'space weather' forecast. The role of tomography in imaging beyond the ionosphere to include the whole near-Earth space-plasma realm is yet to be realized, and provides a challenging prospect for the future. Finally, exciting possibilities exist in applying such methods to image the atmospheres and ionospheres of other planets.     

"How automatic are social judgments?" Correction to Winter, Uleman, and Cunniff.

Reports an error in "How automatic are social judgments" by Laraine Winter, James S. Uleman and Cathryn Cunniff (Journal of Personality and Social Psychology, 1985[Oct], Vol 49[4], 904-917). There are errors in the labeling of the ordinates of the figures. The correct labeling is provided in the erratum. (The following abstract of the original article appeared in record 1986-03720-001.) Adapted the encoding-specificity paradigm developed by D. Thomson and E. Tulving (see record 1971-03487-001) to test 3 operational indicants of automatism (absence of intention, of interference from other mental activity, and of awareness). Recruited for a digit-recall study, 95 undergraduate students read sentences describing actions during the retention interval of either an easy or a difficult digit-recall task. Later, sentence recall was cued by (a) disposition cues, (b) strong semantic associates to the sentence actor, or (c) words representing the gist of the sentence, or (d) sentence recall was not cued. Awareness was measured immediately after the last sentence was read. Disposition-cued recall was higher than (b) or (d) and was unaffected by digit recall difficulty. Awareness of making dispositional inferences was only weakly correlated with disposition-cued recall. Results suggest that disposition inferences occurred at encoding, without intention, without interference by differential drain on processing capacity, and with little awareness. Thus, making dispositional inferences seems to be largely, but not entirely, automatic. (50 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of parental separation and divorce on very young children.

Data from the National Institute of Child Health and Human Development Study of Early Child Care were analyzed to explore effects of marital separation on children in the first 3 years of life. The sample included 73 never-married mothers and 97 separated mothers; a comparison group of 170 was conditionally randomly selected from the 2-parent families. Children in 2-parent families performed better than children in 1-parent families on assessments of cognitive and social abilities, problem behavior, attachment security, and behavior with mother. However, controlling for mothers' education and family income reduced these differences, and associations with separated-intact marital status were nonsignificant (the effect size was .01). Thus, children's psychological development was not affected by parental separation per se; it was related to mothers' income, education, ethnicity, childrearing beliefs, depressive symptoms, and behavior. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Integrated sampling and analytical approach for common groundwater dissolved gases

A novel passive gas diffusion sampler (PGDS) combines sampling, storage and direct injection into a single gas chromatograph (GC). The sampler has a 4.5 mL internal volume when deployed, is easy to operate, and eliminates sample-partitioning. The associated GC method analyzes for a large, dynamic sampling range from a single, small volume injection. Dissolved gases were separated on parallel Rt-Molsieve 5A and Rt-Q-PLOT columns and eluted solutes were quantified using a pulse discharge helium ionization detector (PD-HID). The combined sampling and analytical method appears to be less prone to systematic bias than conventional sampling and headspace partitioning and analysis. Total dissolved gas pressure used in tandem with the PGDS improved the accuracy of dissolved gas concentrations. The incorporation of routine measurements of dissolved biogeochemical and permanent gases into groundwater investigations will provide increased insight into chemical and biological processes in groundwater and improve chemical mass balance accuracy.     

Development of maternal social skills in multiproblem families: Effects on the mother-child relationship.

Tested a two-step infant preventive intervention model: Step 1 was for the mother to improve her interpersonal competence with other adults; Step 2 was for her to learn more optimal parenting behavior. Ss were 147 multiproblem mothers and their infants. Assessed the mothers' adult social skills pre- and posttreatment. Measured the percentage of treatment goals attained during treatment, and mother–child interactive quality posttreatment. Data partially supported the model: For women who began the program with low social skills, the attainment of treatment goals was positively related to posttreatment social skills (Step 1), which, in turn, were positively related to the quality of mother–child interaction (Step 2). For those women who began with high social skills, the treatment was unrelated to posttreatment social skills or to mother–child interaction. Additional analyses explored the factors associated with individual differences in delivery of services and response to treatment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Does Class Size in First Grade Relate to Children's Academic and Social Performance or Observed Classroom Processes?

This study evaluated the extent to which first-grade class size predicted child outcomes and observed classroom processes for 651 children (in separate classrooms). Analyses examined observed child-adult ratios and teacher-reported class sizes. Smaller classrooms showed higher quality instructional and emotional support, although children were somewhat less likely to be engaged. Teachers in smaller classes rated typical children in those classes as more socially skilled and as showing less externalizing behavior and reported more closeness toward them. Children in smaller classes performed better on literacy skills. Larger classrooms showed more group activities directed by the teacher, teachers and children interacted more often, and children were more often engaged. Lower class sizes were not of more benefit (or harm) as a function of the child's family income. First-grade class size in the range typical of present-day classrooms in the United States predicts classroom social and instructional processes as well as relative changes in social and literacy outcomes from kindergarten to first grade. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Application of three-parameter lognormal distribution in EM data analysis

The three-parameter lognormal distribution has been demonstrated for applications in electromigration data analysis, especially for Cu interconnect structures with insufficient redundancy. Examples are given on estimating parameter values from experimental data using the maximum likelihood method. Detailed analyses are presented on confidence bound estimations of the parameters and their propagation to lifetime projections.     

Visual attention modulates signal detectability.

The mechanism by which visual–spatial attention affects the detection of faint signals has been the subject of considerable debate. It is well known that spatial cuing speeds signal detection. This may imply that attentional cuing modulates the processing of sensory information during detection or, alternatively, that cuing acts to create decision bias favoring input at the cued location. These possibilities were evaluated in 3 spatial cuing experiments, with a total of 22 university students. Peripheral cues were used in Exp 1, and central cues were used in Exps 2 and 3. Cuing similarly enhanced measured sensitivity, P(A) and d′, for simple luminance detection in all 3 experiments. Under some conditions it also induced shifts in decision criteria (beta). These findings indicate that visual–spatial attention facilitates the processing of sensory input during detection either by increasing sensory gain for inputs at cued locations or by prioritizing the processing of cued inputs. (PsycINFO Database Record (c) 2010 APA, all rights reserved)