Characterization of neurotoxic effects of NMDA and the novel neuroprotection by phytopolyphenols in mice.

Excitotoxicity plays a major role in various neurological disorders. In this study, we explored the behavioral and neurotoxic effects of intraventricular NMDA administration in mice. After NMDA injection, acute seizures were followed by impairments in locomotor activity, motor performance on a rotarod, and climbing ability. Mice killed 1 day after NMDA administration showed increased synaptosomal reactive oxygen species ROS production and calcium concentration and decreased mitochondrial membrane potential, mitochondrial reductase activities, and neuronal membrane Na+, K+ -ATPase and mg2+ -ATPase activities. One and 3 days after excitotoxic injury, Golgi stains showed that dendritic length and spine density were significantly decreased in neurons of the hippocampal dentate gyrus. Some mice received honokiol, tea polyphenol plus memantine, and honokiol plus memantine prior to NMDA treatment; the occurrence of generalized seizures was attenuated, seizure scores were reduced, latency to generalized seizures was prolonged, and motor impairments were lessened. Moreover, all of the neurochemical changes of the synaptosomes were also ameliorated. In conclusion, the behavioral and neurotoxic effects of intracerebroventricular injection of NMDA were ameliorated by treatment with honokiol alone or combined treatment with either tea polyphenol plus memantine or honokiol plus memantine, but only partly by either tea polyphenol or memantine alone. The therapeutic potential of these neuroprotective regimens in treating excitotoxicity-related diseases merits for further investigation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Diversity analysis of Saccharomyces cerevisiae isolated from natural sources by multilocus sequence typing (MLST)

Food Science and Biotechnology - We used multilocus sequence typing (MLST) to analyze the diversity of natural isolates of Saccharomyces cerevisiae, the most important microorganism in alcoholic...     

木耳出口质量安全风险评估及预防措施综述

本文根据文献报道的木耳生长特性、配方、生产加工工艺流程以及国内外通报的质量安全问题, 综述分析了木耳出口存在的质量安全风险因素, 提出木耳出口质量安全预防控制措施, 阐述了木耳优质安全生产和可持续发展的方向, 为木耳生产和销售企业提供了有益的文献参考。     

Multiple predictors hiding scheme using asymmetric histograms

In recent years, many data hiding techniques have been proposed, and they can be generally classified into two types according to the reversibility of the image; these two types are reversible and irreversible data hiding. This study focused on reversible data hiding, which makes recovering the cover image possible after the secret data has been extracted. In 2013, Chen et al. proposed an asymmetric-histogram reversible data hiding method. In their scheme, two prediction error histograms (maximum and minimum error histograms) were used to embed the secret message. Two histograms were shifted in opposite directions. Hence, some stego-pixels were shifted to their original values. The complementary embedding strategy is effective. However, the predictor in the method is rough. Only neighboring pixels were used to generate the prediction errors, thereby resulting in poor prediction efficiency. To enhance the prediction efficiency, this paper combines several well-known predictors such as gradient adjusted gap (GAP), median edge detect, and interpolation by neighboring pixel (INP) to generate prediction errors. Different predictors along with the asymmetric-histogram method can achieve better results. The predictor GAP used more neighboring pixels to obtain the prediction value; therefore, it is suitable for complex images. However, the predictor INP only considers that closer pixels can achieve great results for smooth images. Hence, the proposed scheme combines GAP and asymmetric histogram for complex images. However, the predictor INP along with asymmetric histogram is used for smooth images. Experimental results showed that the PSNR value of the proposed method is greater than that of the asymmetric-histogram shifting method and other recent approaches.