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Gene therapy for haemophilia A would represent a significant improvement over the current treatment by providing prophylactic expression of FVIII and correction of the coagulation defect. Furthermore, a gene therapy protocol allowing simple, infrequent vector administration may extend haemophilia treatment to remote locations world-wide that currently lack access to FVIII replacement therapy. Within the last half decade, significant progress has been made on the development of gene therapy for the treatment of haemophilia A. Recent achievements include high level clotting factor expression in mice, dogs, and monkeys as well as phenotypic correction in haemophiliac mice and dogs. With the efforts that are currently directed toward the improvement of gene transfer vectors and the development of technologies to enable sustained clotting factor expression, gene therapy for haemophilia A will ultimately become a reality. 相似文献
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Norah E. Dunbar Shane Connelly Matthew L. Jensen Bradley J. Adame Bobby Rozzell Jennifer A. Griffith H. Dan O'Hair 《Journal of Computer-Mediated Communication》2014,19(4):871-889
Ideological groups use the Internet to deliver their messages unhindered by the constraints of traditional media. We examined how ideological groups promote their worldview through their websites. Using the elaboration likelihood model (ELM), this research used trained coders to examine the websites of nonideological groups (n = 37), nonviolent ideological groups (n = 36), and violent ideological groups (n = 32) for credibility, persuasion processing cues, and interactivity factors. Results of this study found that the websites of violent ideological groups use more fear appeals, were less interactive, and were the least credible of the 3 groups. All 3 groups used more central cues than peripheral suggesting they focused on evidence for their arguments rather than emotion. 相似文献
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Lesa Lorenzen Huber Kalpana Shankar Kelly Caine Kay Connelly L. Jean Camp Beth Ann Walker 《International journal of human-computer interaction》2013,29(7):441-455
In-home technologies can support older adults' activities of daily living, provide physical safety and security, and connect elders to family and friends. They facilitate aging in place while reducing caregiver burden. One of older adults' primary concerns about in-home technologies is their potential to reduce human contact, particularly from cherished caregivers. In this exploratory in situ study, we provided an ecosystem of networked monitoring technologies to six older adults and their caregivers. We analyzed the amount and content of communication between them. The amount of noncomputer-mediated communication did not decrease through the 6-week study. The content of communication coalesced into four themes: communication about the technologies, communication facilitated by technologies, intrusiveness of technologies, and fun and playfulness with the technologies. Results suggest that in-home technologies, designed with sensitivity to older adults' primary motivations, have the potential to shape and tailor important relationships in later life. 相似文献
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Comparison of bond strengths of three denture base resins to treated nickel-chromium-beryllium alloy
The success of radiotherapy in eradicating tumours depends on the total radiation dose, but what limits this dose is the tolerance of the normal tissues within the treatment volume. Studies involving fibroblast survival have demonstrated the theoretical feasibility of a predictive assay of radiation sensitivity, but such an assay is still far from clinical application. Using pulsed-field gel electrophoresis (PFGE), we have quantified the initial "apparent" number of DNA double-strand breaks (dsb) induced by the radiation as an alternative measure of sensitivity in 2 different normal cell types from the same patients, epidermal skin cells and lymphocytes. We found significant inter-individual variation in the measured dsb (1-5 dsb/Gy/DNA unit). We also found a linear correlation between molecular damage in lymphocytes and skin samples from the same patient (slope = 0.83; r = 0.694; p = 0.0001). These results suggest that the initial number of dsb could be used as an indicator of the in vivo response to radiation. 相似文献
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An important area of Human Reliability Assessment in interactive systems is the ability to understand the causes of human
error and to model their occurrence. This paper investigates a new approach to analysis of task failures based on patterns
of operator behaviour, in contrast with more traditional event-based approaches. It considers, as a case study, a formal model
of an Air Traffic Control system operator’s task which incorporates a simple model of the high-level cognitive processes involved.
The cognitive model is formalised in the CSP process algebra. Various patterns of behaviour that could lead to task failure
are described using temporal logic. Then a model-checking technique is used to verify whether the set of selected behavioural
patterns is sound and complete with respect to the definition of task failure. The decomposition is shown to be incomplete
and a new behavioural pattern is identified, which appears to have been overlooked in the informal analysis of the problem.
This illustrates how formal analysis of operator models can yield fresh insights into how failures may arise in interactive
systems.
相似文献
Antonio Cerone (Corresponding author)Email: |
Simon ConnellyEmail: |
Peter LindsayEmail: |
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Michael G. Hughes Jennifer A. Griffith Thomas A. Zeni Matthew L. Arsenault Olivia D. Cooper Genevieve Johnson Jay H. Hardy Shane Connelly Michael D. Mumford 《Journal of Computer-Mediated Communication》2014,19(3):325-341
Given the prevalence of online media today, credibility continues to be a popular subject of empirical research. However, studies examining the effects of discrediting strategies are rare. This issue is significant given the popularity of online media and the ease of such sources to spread misinformation. Therefore, the present study examines the effects of attacking the expertise and trustworthiness of a proponent of a major social issue. Results showed that support as well specific combinations of discrediting attack strategies significantly reduced message board readers' perceptions of the proponent's credibility. In addition, attacks on either the proponent's expertise or trustworthiness resulted in a reduced likelihood of readers taking action with respect to the issue. 相似文献
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JJ Bauer RR Connelly IA Seterhenn S Srivastava DG McLeod JW Moul 《Canadian Metallurgical Quarterly》1998,163(9):615-619
OBJECTIVE: To predict the risk of extracapsular extension and postoperative recurrence before radical prostatectomy (RP) for prostate cancer. METHODS: We performed multivariate Cox regression analysis on preoperative variables in 260 clinically localized prostate cancer patients who underwent RP. With these data, we constructed a relative risk of recurrence (Rr) equation and an equation to predict the probability of extracapsular extension (PECE) before RP. RESULTS: Rr is calculated as exp[(0.47 x race + 0.14 x PSAST) + (0.13 x worst biopsy Gleason sum) + (1.03 x stage T1c) + (1.55 x stage T2b,c)], where PSAST indicates a sigmoidal transformation of prostate-specific antigen. PECE is calculated as 1/[1 + exp(-Z)], where Z = -2.47 + 0.15 (PSAST) + 0.31 (worst biopsy Gleason sum) + 0.18 (race) + 0.16 (stage T1c) + 0.38 (stage T2b,c). CONCLUSION: These two equations can be used preoperatively to predict the probability of extracapsular disease and the risk of prostate-specific antigen recurrence in patients undergoing RP. 相似文献