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Alexei Manso Corrêa Machado 《Journal of Mathematical Imaging and Vision》2007,29(2-3):107-117
We present a novel method for correcting the significance level of hypothesis testing that requires multiple comparisons. It is based on the spectral graph theory, in which the variables are seen as the vertices of a complete undirected graph and the correlation matrix as the adjacency matrix that weights its edges. The method increases the statistical power of the analysis by refuting the assumption of independence among variables, while keeping the probability of false positives low. By computing the eigenvalues of the correlation matrix, it is possible to obtain valuable information about the dependence levels among the variables of the problem, so that the effective number of independent variables can be estimated. The method is compared to other available models and its effectiveness illustrated in case studies involving high-dimensional sets of variables. 相似文献
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S Kozlowski M Corr M Shirai LF Boyd CD Pendleton JA Berzofsky DH Margulies 《Canadian Metallurgical Quarterly》1993,151(8):4033-4044
T cell stimulation by certain class I-restricted antigenic peptides, such as the HIV 1 gp160-derived peptide, P18, requires peptide processing by angiotensin-1 converting enzyme (ACE) in FCS. We observed that longer versions of P18 and the murine cytomegalovirus pp89-derived core peptide, pMCMV, which could stimulate T cell hybridomas in FCS, were not as sensitive to the ACE inhibitor captopril as P18. Using cell-free soluble murine class I MHC molecules and protease inhibitors, we found that there are pathways of differing efficiency that use enzymes other than ACE for the proteolytic processing of peptides in serum. The kinetics of the generation of T cell stimulatory activity among P18 variant peptides in serum differed with peptide length, and with the nature of amino and COOH-terminal extensions. Such processing occurs in human plasma as well as in FCS. The understanding of this processing, its kinetics, and its inhibitors can lead to better design of peptide-based therapies, including vaccines. 相似文献
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Erick Corrêa da Silva Aristófanes Corrêa Silva Anselmo Cardoso de Paiva Rodolfo Acatauassu Nunes 《Pattern Analysis & Applications》2008,11(1):89-99
This paper analyzes the application of Moran’s index and Geary’s coefficient to the characterization of lung nodules as malignant
or benign in computerized tomography images. The characterization method is based on a process that verifies which combination
of measures, from the proposed measures, has been best able to discriminate between the benign and malignant nodules using
stepwise discriminant analysis. Then, a linear discriminant analysis procedure was performed using the selected features to
evaluate the ability of these in predicting the classification for each nodule. In order to verify this application we also
describe tests that were carried out using a sample of 36 nodules: 29 benign and 7 malignant. A leave-one-out procedure was
used to provide a less biased estimate of the linear discriminator’s performance. The two analyzed functions and its combinations
have provided above 90% of accuracy and a value area under receiver operation characteristic (ROC) curve above 0.85, that
indicates a promising potential to be used as nodules signature measures. The preliminary results of this approach are very
encouraging in characterizing nodules using the two functions presented.
相似文献
Rodolfo Acatauassu NunesEmail: |
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Jony Javorski Eckert Ludmila Corrêa de Alkmin e Silva Fabio Mazzariol Santiciolli Eduardo dos Santos Costa Fernanda Cristina Corrêa Franco Giuseppe Dedini 《国际能源研究杂志》2018,42(11):3506-3523
Two big issues involving electric vehicles are energy supply and power management control. To deal with the energy supply problem, this paper proposes the application of a hybrid energy source system, composed of battery pack and ultracapacitor bank. The power management control between the energy supplies was defined by a fuzzy logic with inference rules optimized through genetic algorithm. The genetic algorithm optimizes lower and upper limits of membership functions aiming to reduce the hybrid energy source system total mass while maximizing the electric vehicle drive range and performance. Through the Pareto frontier, we found the best trade‐off solution. 相似文献
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Igor Otavio Minatel Fabiane Valentini Francisqueti Camila Renata Corrêa Giuseppina Pace Pereira Lima 《International journal of molecular sciences》2016,17(8)
γ-oryzanol (Orz), a steryl ferulate extracted from rice bran layer, exerts a wide spectrum of biological activities. In addition to its antioxidant activity, Orz is often associated with cholesterol-lowering, anti-inflammatory, anti-cancer and anti-diabetic effects. In recent years, the usefulness of Orz has been studied for the treatment of metabolic diseases, as it acts to ameliorate insulin activity, cholesterol metabolism, and associated chronic inflammation. Previous studies have shown the direct action of Orz when downregulating the expression of genes that encode proteins related to adiposity (CCAAT/enhancer binding proteins (C/EBPs)), inflammatory responses (nuclear factor kappa-B (NF-κB)), and metabolic syndrome (peroxisome proliferator-activated receptors (PPARs)). It is likely that this wide range of beneficial activities results from a complex network of interactions and signals triggered, and/or inhibited by its antioxidant properties. This review focuses on the significance of Orz in metabolic disorders, which feature remarkable oxidative imbalance, such as impaired glucose metabolism, obesity, and inflammation. 相似文献
9.
Gerson Reginaldo Marques Soraia Vilela Borges Diego Alvarenga Botrel Joyce Maria Gomes da Costa Eric Keven Silva Jefferson Luiz Gomes Corrêa 《Drying Technology》2014,32(7):861-868
Maize (Zea mays) is a cereal grown in Brazil, and its availability is limited to the harvest season. An alternative processing route is based on the production of green corn powder, which has a longer shelf-life and increased versatility. This study aimed to evaluate the influence of drying conditions on the physical characteristics, size, and morphology of green corn powder. Drying experiments were performed on a spray dryer according to a central composite rotational design to evaluate inlet air temperature, feed flow rate, and pulp concentration. The yield of dried pulp corn had an average value of 36.19%. The following mean values for the physical properties of the powder were measured: solubility of 94.37 g/100 g, wettability of 128.05 seconds, moisture content of 1.97%, water activity of 0.13, density of 0.79 g/mL, and a particle diameter of 31.02 µm. The powder was also yellow with less intensity, and the particle surface was smooth at higher temperatures and had a tendency to form agglomerates. The estimated optimal conditions for spray drying were 48% (w/w) pulp concentration, 172°C inlet air temperature, and feed flow rate of 0.56 L/h. 相似文献
10.
Roasting,Grinding, and Storage Impact on Thermodynamic Properties and Adsorption Isotherms of Arabica Coffee
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