Hypermutability of mouse chromosome 2 during the development of x-ray-induced murine myeloid leukemia

In an effort to identify the precise role of a deletion at regions D-E of mouse chromosome 2 [del2(D-E)] during the development of radiation-induced myeloid leukemia, we conducted a serial sacrifice study in which metaphase chromosomes were examined by the G-banding technique. Such metaphase cells were collected from x-irradiated mice during the period of transformation of some of the normal hematopoietic cells to the fully developed leukemic phenotype. A group of 250 CBA/Ca male mice (10-12 weeks old) were exposed to a single dose of 2 Gy of 250-kilovolt-peak x-rays; 42 age-matched male mice served as controls. Groups of randomly selected mice were sacrificed at 20 hr, 1 week, and then at intervals of 3 months up to 24 months after x-irradiation. Slides for cytogenetic, hematological, and histological examination were prepared for each animal at each sacrifice time. An expansion of cells with lesions on one copy of chromosome 2 was evident in 20-25% of treated mice at each sacrifice time. The majority of such lesions were translocations at 2F or 2H, strongly suggesting hypermutability of these sites on mouse chromosome 2. No lesions were found in control mice. The finding leads to the possibility that genomic lesions close to 2D and 2E are aberrants associated with radiation leukemogenesis, whereas a single clone of cells with a del2(D-E) may lead directly to overt leukemia. The data also indicate that leukemic transformation arises from the cumulative effects of multiple genetic events on chromosome 2, reinforcing the thesis that multiple steps of mutation occur in the pathogenesis of cancer.     

Unipolar Depression, Life Context Vulnerabilities, and Drinking to Cope.

This study followed baseline samples of 424 unipolar depressed patients and 424 community controls across 10 years to investigate the association between depression and alcohol-related coping and to examine how life context vulnerabilities underlie the risk for depressed individuals to rely on drinking to cope. Findings supported all hypotheses. Depressed patients engaged in more drinking to cope than did community controls. Within individuals, more negative life events and less family support were associated with more drinking to cope across the 4 observations. Depressed patients experienced more negative life events and less family support than did community controls. These underlying life context vulnerabilities explained the relationship between depressed patient status and drinking to cope. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Drinking to cope and alcohol use and abuse in unipolar depression: A 10-year model.

This study examined drinking to cope with distress and drinking behavior in a baseline sample of 412 unipolar depressed patients assessed 4 times over a 10-year period. Baseline drinking to cope operated prospectively as a risk factor for more alcohol consumption at 1-, 4, and 10-year follow-ups and for more drinking problems at 1- and 4-year follow-ups. Findings elucidate a key mechanism in this process by showing that drinking to cope strengthened the link between depressive symptoms and drinking behavior. Individuals who had a stronger propensity to drink to cope at baseline showed a stronger connection between depressive symptoms and both alcohol consumption and drinking problems. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Evaluating alcoholism treatment programs: An integrated approach.

Examines the interrelationships among 5 major sets of variables (social background, intake symptoms, program type, treatment experiences, and perceptions of the environment) that are related to posttreatment functioning of alcoholic patients (alcohol consumption, rating of drinking problem, physical impairment, and occupational functioning). The sample consisted of 429 patients selected from 5 different treatment programs. All Ss completed the Community-Oriented Program Evironment Scale about 2 wks after admission to measure their perceptions of the program environment. The relative importance of each set of variables as predictors of outcome was estimated by constructing block variables, using path analyses, and partitioning the explained variance. Results show that (a) the combined explanatory power of the program-related variables is considerably more than would be expected from previous research; (b) the importance of patient background relative to intake symptoms varies with the outcome criterion being used; (c) both the treatment experiences and the patient's perceptions of the treatment environment are strong predictors of outcome; and (d) a substantial proportion of the explained variance is shared between patient-related and program-related variables, suggesting important patient-program selection and congruence effects. (22 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The long-term interplay between family and extrafamily resources and depression.

A 3-wave prospective panel model was used to examine the idea that depression erodes an individual's social resources and that lack of social resources contributes to depression. The data are from 313 depressed patients assessed at intake to treatment and at 1-year and 10-year follow-ups. There was little or no evidence for a social selection effect in which depression contributed to a decline in family or extrafamily resources. In contrast, there was evidence for a social causation effect in which family and extrafamily resources contributed to changes in depression. These findings imply that family and extrafamily resources can contribute to a decline in depression and that depressed individuals' social resources do not necessarily deteriorate over time. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Spousal similarity in coping and depressive symptoms over 10 years.

Following a baseline sample of 184 married couples over 10 years, the present study develops a broadened conceptualization of linkages in spouses' functioning by examining similarity in coping as well as in depressive symptoms. Consistent with hypotheses, results demonstrated (a) similarity in depressive symptoms within couples across 10 years, (b) similarity in coping within couples over 10 years, and (c) the role of coping similarity in strengthening depressive similarity between spouses. Spousal similarity in coping was evident for a composite measure of percent approach coping as well as for component measures of approach and avoidance coping. The role of coping similarity in strengthening depressive symptom similarity was observed for percent approach coping and for avoidance coping. These findings support social contextual models of psychological adjustment that emphasize the importance of dynamic interdependencies between individuals in close relationships. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Life stressors, social resources, coping, and the 4-year course of unipolar depression.

Little is known about the effects of psychosocial factors on the long-term course of unipolar depression. This article examines the 4-year stability and change in life stressors, social resources, and coping, and their effect on the course of treated unipolar depression among 352 men and women. Depressed patients were assessed at treatment intake and at 1-year and 4-year follow-ups. Over the 4 years, patients improved in symptom outcomes, the quality of social resources, and coping responses; there were some declines in life stressors. Life stressors, social resources, and coping were related to patient functioning concurrently, after controlling for demographics, initial treatment, and initial dysfunction severity. Preintake medical conditions and family conflict consistently predicted poorer long-term outcomes. The findings imply that medical conditions and family conflict are important risk factors that predict poorer long-term outcome of depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Family and extrafamily resources and the 10-year course of treated depression

A group of 313 depressed patients and 284 controls was assessed at baseline (treatment intake for the patients) and at 1-year, 4-year, and 10-year follow-ups. Stably remitted patients achieved levels of family and extrafamily resources that were comparable with those of the controls. Although partially remitted and nonremitted patients' social resources improved, they continued to show deficits in these areas relative to controls and stably remitted patients. Several indexes of social resources predicted stable remission: more family independence, fewer family arguments and less conflict, and more helpful friends and activities with friends. Assessment of social resources at treatment intake and short-term follow-ups can help identify and provide intervention foci for patients at risk for nonremission of depression.     

Resource loss, resource gain, and depressive symptoms: A 10-year model.

This study examined a broadened conceptualization of the stress and coping process that incorporated a more dynamic approach to understanding the role of psychosocial resources in 326 adults studied over a 10-year period. Resource loss across 10 years was significantly associated with an increase in depressive symptoms, whereas resource gain across 10 years was significantly associated with a decrease in depressive symptoms. In addition, change in the preponderance of negative over positive events across 10 years was inversely associated with change in resources during the period. Finally, in an integrative structural equation model, the association between change in life events and depressive symptoms at follow-up was completely mediated through resource change. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Social-environmental factors in unipolar depression: Comparisons of depressed patients and nondepressed controls.

Examined the role of stress and coping factors in depression by comparing a group of 409 Ss (over age 18) entering psychiatric treatment for unipolar depression with a sociodemographically matched group of 409 nondepressed Ss. In addition to reporting significantly more stressful events than controls, depressed Ss also experienced more severe life strains associated with their own and their family members' physical illness, their family relationships, and their home and work situations. Depressed Ss were less likely to use problem-solving and more likely to use emotion-focused coping responses and had fewer and less supportive relationships with friends, family members, and co-workers. These group differences were consistent for both depressed women and men. Findings indicate the value of expanding the consideration of psychosocial factors in depression to include individuals' chronic strains and acute stressors as well as their coping responses and social resources. (53 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)