4/spl times/10 GHz mode-locked multiple-wavelength fiber laser

We demonstrate a four-wavelength 10-GHz mode-locked erbium-doped fiber laser, with wavelength spacings of 3.5-5 nm. Nearly transform-limited Gaussian pulses of 11- to 14-ps duration are measured and all wavelengths are synchronous.     

Performance of interface engineeredSiNx/ICL/InP/In0.53Ga0.47As/InP dopedchannel HIGFET's

SiN_x/InP/InGaAs doped channel passivated heterojunction insulated gate field effect transistors (HIGFETs) have been fabricated for the first time using an improved In-S interface control layer (ICL). The insulated gate HIGFETs exhibit very low gate leakage (10 nA@V_GS =±5 V) and I_DS (sat) of 250 mA/mm. The doped channel improves the DC characteristics and the HIGFETs show transconductance of 140-150 mS/mm (L_g=2 μm), f_t of 5-6 GHz (L_g=3 μm), and power gain of 14.2 dB at 3 GHz. The ICL HIGFET technology is promising for high frequency applications     

Correlation between vascular and cellular responses to atrial natriuretic peptide and to sodium nitroprusside

Atrial natriuretic peptide (ANP) and sodium nitroprusside (SNP) increase cGMP in vascular smooth muscle cells and act as vasodilators in some, but not all, blood vessels. In this present study, we attempted to correlate the ability of these two agents to dilate blood vessels with the ability to increase cGMP in cultured vascular smooth muscle cells. In the isolated guinea pig heart, SNP dose-dependently increased coronary flow while ANP was ineffective. In smooth muscle cells cultured from the coronary system, SNP increased intracellular cGMP in a dose-dependent manner while ANP had no effect on cGMP in these cells. In isolated guinea-pig thoracic aorta, precontracted with K+, both ANP and SNP produced relaxation and ANP was the more potent. In smooth muscle cells cultured from the aorta, ANP and SNP increased cGMP and the potency relationship was similar to the intact vessel. These results support the view that phenotypic properties of vascular smooth muscle cells can account for differences in the response of blood vessels to vasodilators.     

Hedgehog''s escape from Pandora''s box

The Hedgehog family of secreted glycoproteins proteins plays multifarious roles during vertebrate embryogenesis. In both the Drosophila and vertebrate embryo correct deployment of Hedgehog-like proteins is critical for the generation of pattern in many tissues and organs. New evidence now reveals that genes involved in hedgehog signalling are mutated in a number of common human genetic disorders, including skin cancer and craniofacial defects. The understanding of how cells generate, receive and transduce the Hedgehog signal during development has led to the establishment of molecular paradigms for the pathogenesis of these diseases. These studies clearly illustrate that knowledge of the normal role of a gene during development is critical for generating an understanding of the disease state in which it is mutated.     

HEAT TRANSFER BETWEEN ROUGH SURFACES IN CONTACT OVER A HIGHLY ELLIPTICAL CONTOUR AREA: COMPARISON OF EXPERIMENTAL AND NUMERICAL RESULTS

This paper describes experimental and numerical studies of heat transfer between surfaces in contact over a highly elliptical area in a gas or in vacuum. Measurements of the steady-state thermal resistance of a high aspect ratio contact formed between cylindrical steel surfaces with widely different radii of curvature (76 cm vs 0.95 cm) are reported for two levels of surface roughness (0.05 μm and 1.0 μm rms) and compared to 3-D numerical results obtained with the multigrid method. Theoretical results obtained by evaluating the contact conductance acting over each surface element within the contour area with a method developed previously for rough but nominally flat surfaces are shown to be in excellent agreement with the rough surface experimental data.     

Application strategies for Sechura phosphate rock use on permanent pasture

At two phosphate (P) responsive sites in hill country the effectiveness of Sechura phosphate rock (SPR) as a direct application P fertilizer for permanent pasture was evaluated. Sechura was applied at two rates, in three different application strategies. The treatments were 16.7 and 50 kgP ha^–1 annually, 25 and 75 kgP ha^–1 biennially, and 50 and 150 kgP ha^–1 triennially giving a total of 50 and 150 kgP ha^–1, respectively, over three years. Single superphosphate (SSP) served as the standard P fertilizer. A comparison was also made between SPR and Chatham Rise phosphorite (CRP), another reactive PR. Total pasture and legume production and P uptake by pasture was measured with all fertilizer treatments over a three year period.In the year of application, SPR was as effective as SSP in stimulating total pasture and legume production and P uptake by pasture. This reflects the very reactive nature of this PR. In the second and third years of measurement, SPR did not show superior residual efffects to SSP. The ability of CRP to stimulate legume growth more than SPR in the second year following application demonstrates the danger of generalizing about the residual effects of reactive PR materials. Of the application strategies evaluated, a biennial appplication of 25 kgP ha^–1 as SPR maintained legume growth at a higher level than a smaller (16.7 kgP ha^–1) annual dressing. The biennial strategy also increased total pasture yield, in addition to legume production to a greater extent in the second and third years than a single (50 kgP ha^–1) triennial application.     

Inductive transfer with context-sensitive neural networks

Context-sensitive Multiple Task Learning, or csMTL, is presented as a method of inductive transfer which uses a single output neural network and additional contextual inputs for learning multiple tasks. Motivated by problems with the application of MTL networks to machine lifelong learning systems, csMTL encoding of multiple task examples was developed and found to improve predictive performance. As evidence, the csMTL method is tested on seven task domains and shown to produce hypotheses for primary tasks that are often better than standard MTL hypotheses when learning in the presence of related and unrelated tasks. We argue that the reason for this performance improvement is a reduction in the number of effective free parameters in the csMTL network brought about by the shared output node and weight update constraints due to the context inputs. An examination of IDT and SVM models developed from csMTL encoded data provides initial evidence that this improvement is not shared across all machine learning models.     

Exploring the supply-side of IT outsourcing: evaluating the emerging role of application service providers

The paper explores the supply-side of IT outsourcing by focusing upon the emerging role of application service providers (ASPs). It traces the transition from first wave IT outsourcing in the 1960s, to business-centric outsourcing in the 1980s and 90s to application outsourcing in the 21st century. Drawing from empirical research on a taxonomy of ASPs, the paper explores how application outsourcing is currently changing the nature of the outsourcing contract and relationship between client and supplier. This will have significant implications for traditional outsourcing and ERP vendors in the software and computing services industry, in addition to presenting new opportunities to SMEs with little history or experience of outsourcing.     

Self-improving process control for molecular beam epitaxy

This paper addresses manufacturing research involving advances in material process control. The research objective has been to develop intelligent, self-directed and self-improving control systems which enablein situ (real-time) control path generation based on both product (material behaviour) and processing (control agent) feedback. A product-process control philosophy which emphasises product quality is described together with a generic architecture for representing product and process knowledge.Specific details are presented involving the development and application of a self-directed and self-improving material processing system for molecular beam epitaxy of gallium arsenide wafers. Special emphasis is given to the development of a neural model for self-improving control as well as future research directions.     

An evaluation of the development of IT in a college of nursing and midwifery

This paper presents the findings of a case study of the development of IT in a College of Nursing and Midwifery. Data were collected by means of postal questionnaires, interviews, focus groups, direct observations and documentary evidence. The findings suggest that the majority of staff used some form of IT on a regular basis, but only 50% of students used college-based IT facilities. The main use of IT was for administrative and productive purposes and there was little evidence of IT in teaching/learning methods. Training offered to staff was poorly attended and training offered to students did not meet what they perceived as their needs. Although most staff used IT there was still evidence of resistance and stress related to IT use. The use of IT in the study college was driven by tactical considerations rather than as a part of an explicit strategy.