Fetal alcohol syndrome in twins of alcoholic mothers: concordance of diagnosis and IQ

The effects of teratogens can be modified by genetic differences in fetal susceptibility and resistance. Twins of alcoholic mothers provide a unique opportunity to study this phenomenon with respect to alcohol teratogenesis. Sixteen pairs of twins, 5 MZ and 11 DZ, all heavily exposed to alcohol prenatally, were evaluated. They represented all available twins of alcohol-abusing mothers who were on the patient rolls of the authors. The rate of concordance for diagnosis was 5/5 for MZ and 7/11 for DZ twins. In two DZ pairs, one twin had fetal alcohol syndrome (FAS), while the other had fetal alcohol effects (FAE). In 2 other DZ pairs, one twin had no diagnosis while one had FAE. IQ scores were most similar within pairs of MZ twins and least similar within pairs of DZ twins discordant for diagnosis. Despite equivalent alcohol exposure within twin pairs, alcohol teratogenesis appears to be more uniformly expressed in MZ than in DZ twins. These data are interpreted as reflecting the modulating influence of genes in the expression of the teratogenic effects of alcohol.     

High-speed single cable synchronization system for data-converters

A clock-cycle accurate synchronization technique for fully integrated data-converters is presented. Only a single cable is needed to distribute both the required synchronization signal and the converter clock. Different possible implementations, both to generate and decompose the distributed signal, are presented. A discrete component generator circuit is discussed. To avoid setup and hold time violations, on-chip signal reconstruction is unavoidable. A 40 nm CMOS recovery circuit was developed. Simulation results, including layout parasitics, show the wide frequency operating range of the proposed technique.     

Is numerical comparison digital? Analogical and symbolic effects in two-digit number comparison.

Do Ss compare multidigit numbers digit by digit (symbolic model) or do they compute the whole magnitude of the numbers before comparing them (holistic model)? In 4 experiments of timed 2-digit number comparisons with a fixed standard, the findings of J. V. Hinrichs et al (see record 1982-07073-001) were extended with French Ss. Reaction times (RTs) decreased with target-standard distance, with discontinuities at the boundaries of the standard's decade appearing only with standards 55 and 66 but not with 65. The data are compatible with the holistic model. A symbolic interference model that posits the simultaneous comparison of decades and units can also account for the results. To separate the 2 models, the decades and units digits of target numbers were presented asynchronously in Experiment 4. Contrary to the prediction of the interference model, presenting the units before the decades did not change the influence of units on RTs. Pros and cons of the holistic model are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Energy Efficient Memory Architecture for High Speed Decoding of Block Turbo-Codes with the Fang-Buda Algorithm

Block Turbo-codes (BTC) are promising forward error correction (FEC) codes providing close-to-optimal coding gain for rather high coding rate (R > 0.7) and less subject to an error floor than Convolution Turbo Codes (CTC). Due to its good convergence properties, the Fang-Buda algorithm (FBA) allows efficiently decoding BTC in far less iterations than traditional soft-decoding algorithms such as Chase's algorithm. Moreover it can handle BTC inner code with higher minimum distance, improving consequently coding performances. However, the FBA data-intensive character and its very complex control structure are dramatic bottlenecks for a low-power, high-throughput implementation. Therefore, currently available BTC decoders are based on some variants of the Chase algorithm and can only handle simple BTC inner codes. In order to enable high performance BTCs without sacrificing throughput or energy, we have systematically analyzed and optimized the FBA algorithm, applying a systematic methodology to improve the data transfer and storage characteristics. This paper details the algorithm transformation steps and the resulting memory architecture. The latter, when mapped in a typical 0.18 μm technology and clocked at 200 MHz, enables BTCs with maximum throughput up to 134 Mbps. The memory power consumption, which is dominant for such a data-dominated application, has been estimated, after optimization, to 16 nJ/bit while the memory area estimation led to 3.5 mm² per FBA module in the BTC pipeline.     

Abstract representations of numbers in the animal and human brain

There is evidence to suggest that animals, young infants and adult humans possess a biologically determined, domain-specific representation of number and of elementary arithmetic operations. Behavioral studies in infants and animals reveal number perception, discrimination and elementary calculation abilities in non-verbal organisms. Lesion and brain-imaging studies in humans indicate that a specific neural substrate, located in the left and right intraparietal area, is associated with knowledge of numbers and their relations ('number sense'). The number domain is a prime example where strong evidence points to an evolutionary endowment of abstract domain-specific knowledge in the brain because there are parallels between number processing in animals and humans.The numerical distance effect, which refers to the finding that the ability to discriminate between two numbers improves as the numerical distance between them increases, has been demonstrated in humans and animals, as has the number size effect,which refers to the finding that for equal numerical distance,discrimination of two numbers worsens as their numerical size increases.     

A neuronal model of a global workspace in effortful cognitive tasks

A minimal hypothesis is proposed concerning the brain processes underlying effortful tasks. It distinguishes two main computational spaces: a unique global workspace composed of distributed and heavily interconnected neurons with long-range axons, and a set of specialized and modular perceptual, motor, memory, evaluative, and attentional processors. Workspace neurons are mobilized in effortful tasks for which the specialized processors do not suffice. They selectively mobilize or suppress, through descending connections, the contribution of specific processor neurons. In the course of task performance, workspace neurons become spontaneously coactivated, forming discrete though variable spatio-temporal patterns subject to modulation by vigilance signals and to selection by reward signals. A computer simulation of the Stroop task shows workspace activation to increase during acquisition of a novel task, effortful execution, and after errors. We outline predictions for spatio-temporal activation patterns during brain imaging, particularly about the contribution of dorsolateral prefrontal cortex and anterior cingulate to the workspace.     

The stroke syndrome of cortical vein thrombosis

Cortical vein thrombosis without sinus involvement is rarely diagnosed, although it may commonly be overlooked. We report four cases of cerebral venous thrombosis limited to the cortical veins. The diagnosis was made on surgical intervention in one patient and by angiography in three patients. Together with a survey of the published cases, the clinical and neuroimaging patterns of our patients allow delineation of several features suggestive of cortical venous stroke. Focal or generalized seizures followed by hemiparesis, aphasia, hemianopia, or other focal neurologic dysfunction in the absence of signs of increased intracranial pressure should suggest this possibility. Neuroimaging (CT, MRI) shows an ischemic lesion that does not follow the boundary of arterial territories and often has a hemorrhagic component, without signs of venous sinus thrombosis. Conventional angiography demonstrates no arterial occlusion but may show cortical vein thrombosis corresponding to the infarct, although these may also be nonspecific findings. The role of MR angiography, which is well-established in sinus thrombosis, remains to be assessed in patients with brain ischemia due to isolated cortical vein occlusion.     

A CMOS rectifier-integrator for amplitude detection in hard diskservo loops

In this paper a CMOS alternative amplitude detection system is presented. It is designed as an alternative for the, bipolar, amplitude detection in hard disk servo systems. The amplitude is detected by converting the input voltage to a current, rectifying the current, and integrating it on a capacitor. For this a new OTA topology and a rectifier cell are designed. This circuitry is expanded with a very linear current mirror and an automatic offset compensation system to cope with technology spread. The measured accuracy of the amplitude detector is 0.2% (9 b). This makes the circuit suitable for implementation in state-of-the art hard disk systems with very high track densities and very short access times. Because the circuit is realized in standard CMOS it is a further step toward CMOS only hard disk electronics. Because the circuit operates from a single 3 V power supply and has limited power consumption it can be used in battery powered systems     

Full CMOS continuous time filters for GSM applications

This paper describes full cmoscontinuous time filter design techniques which can meet the specifications commonly set for gsmapplications. First several cmosfilter design techniques are overviewed. The ota-ctechnique is discussed to some more detail. To overcome the main drawback of the lower total harmonic distortion in ota-ctechniques very linear operational transconductance amplifiers (ota)are required. Such an ota,together with the applied linearisation techniques is discussed. To fulfil high accuracy in cut- off frequencies of the filter an active tuning system is necessary. A new on- chip tuning system is presented. The paper concludes with a practical design example for the gsmsystem. Therein the different ota-ctechniques discussed are illustrated.