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排序方式: 共有122条查询结果,搜索用时 15 毫秒
1.
Vancha Harish Effi Haque Magdalena
miech Hiroaki Taniguchi Sarah Jamieson Devesh Tewari Anupam Bishayee 《International journal of molecular sciences》2021,22(9)
Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. XH acts as a wide ranging chemopreventive and anticancer agent, and its isomer, 8-prenylnaringenin, is a phytoestrogen with strong estrogenic activity. The present review focuses on the bioactivity of XH on various types of cancers and its pharmacokinetics. In this paper, we first highlight, in brief, the history and use of hops and then the chemistry and structure–activity relationship of XH. Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and treatment. Considering the limited number of available reviews on this subject, our goal is to provide a complete and detailed understanding of the anticancer effects of XH against different cancers. 相似文献
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Response surface methodology was advantageously used to optimally immobilise a β-galactosidase from chick pea onto alkylamine glass using Box–Behnken experimental design, resulting in an overall 91% immobilisation efficiency. Analysis of variance was performed to determine the adequacy and significance of the quadratic model. Immobilised enzyme showed a shift in the optimum pH; however, optimum temperature remained unaffected. Thermal denaturation kinetics demonstrated significant improvement in thermal stability of the enzyme after immobilisation. Galactose competitively inhibits the enzyme in both soluble and immobilised conditions. Lactose in milk whey was hydrolysed at comparatively higher rate than that of milk. Immobilised enzyme showed excellent reusability with retention of more than 82% enzymatic activity after 15 uses. The immobilised enzyme was found to be fairly stable in both dry and wet conditions for three months with retention of more than 80% residual activity. 相似文献
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Oil-in-water emulsions are used as metalworking fluids (MWFs). Considering the environmental issues and operator's health, the amount of oil-in-MWFs is one of the important parameters. In the present study, paraffin oil is used for emulsion formulation and possibilities to minimize the amount of paraffin oil-in-MWFs are explored. Physical characterization of emulsions is done using dynamic light scattering and goniometer. The tribological response of emulsions is recorded using the Four-ball tester. Results indicate that the amount of oil can be brought down to a level of 0.5% v/v to achieve the standard friction level. Droplet size and distribution seems to control the lubricity of emulsions, smaller droplets are desired for better lubrication. 相似文献
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Sanjay Sharma Devesh Dubey 《The International Journal of Advanced Manufacturing Technology》2010,51(9-12):1171-1178
Purchase allocation is a multi criteria decision making (MCDM) problem. Multitude of qualitative and quantitative factors is involved in the multiple sourcing decisions. Analytic hierarchy process (AHP) has widely been used to find out the relative rankings of suppliers. AHP can be combined with regular supplier quantitative audit process. In classical AHP, decision maker (DM) has to pair wise compare suppliers for each factor, whereas the proposed audit based simplified AHP will remove the complexity of comparison. Quarterly audit-based AHP rankings and supplier performance probability products can be used in place of revenues in the backward recursive resource allocation knapsack model. This combined model will decompose purchase allocation problem into different stages and combine one supplier at each stage and provide the optimum and feasible solution in the end. Solution at each stage is also a feasible option. This model is only applicable when the total order quantity and the capacity of all suppliers are integer multiples of economic or minimum order quantity. This integrated model thus provides number of orders/supplier. 相似文献
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Wireless Personal Communications - Grid based sensor networks are significant for applications such as monitoring goods in a warehouse, studying traffic level of city streets, monitoring energy... 相似文献
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Singh A. K. Chandra Devesh Kattayat Sandhya Kumar Shalendra Alvi P. A. Rathi Amit 《Semiconductors》2019,53(12):1584-1592
Semiconductors - Compositional variations in GaAs based ternary alloys have exhibited wide range alterations in electronic properties. In the present paper, first-principles study of... 相似文献
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