Verbal operant conditioning of hospitalized psychiatric patients.

In Exp. I, 81 male psychiatric patients were divided into 9 subgroups according to age and length of hospitalization. Plural nouns were reinforced by positive verbal feedback. Results were: (1) least chronic Ss increased their operant rates; (2) most chronic Ss did not; and (3) there was significant interaction with respect to age and chronicity. In Exp. II, 60 schizophrenics were divided into 6 subgroups with respect to length of hospitalization and mode of reinforcement, i.e., verbal, primary, or combination. Acute-type schizophrenics responded positively to all types of reinforcement. Chronics responded only to primary reinforcement and to the combination procedure. Mode of reinforcement was a significant variable affecting operant rate. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Transfer of the effects of verbal conditioning.

Experimental Ss were verbally conditioned to use more future tense responses in making up sentences. Transfer effects were assessed using a 2nd sentence completion task containing certain stimulus cues present on the original task. Transfer of learning was demonstrated on the basis of a grossly defined, 2-step gradient of similarity of stimulus cues contained on the learning and transfer tasks. The variables of S's awareness and S's sex did not lead to statistically significant between-group differences. The response form (written vs. oral) also failed to demonstrate a significant effect. (15 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rationally Designed Polypharmacology: α-Helix Mimetics as Dual Inhibitors of the Oncoproteins Mcl-1 and HDM2

Protein–protein interactions (PPIs), many of which are dominated by α-helical recognition domains, play key roles in many essential cellular processes, and the dysregulation of these interactions can cause detrimental effects. For instance, aberrant PPIs involving the Bcl-2 protein family can lead to several diseases including cancer, neurodegenerative diseases, and diabetes. Interactions between Bcl-2 pro-life proteins, such as Mcl-1, and pro-death proteins, such as Bim, regulate the intrinsic pathway of apoptosis. p53, a tumor-suppressor protein, also has a pivotal role in apoptosis and is negatively regulated by its E3 ubiquitin ligase HDM2. Both Mcl-1 and HDM2 are upregulated in numerous cancers, and, interestingly, there is crosstalk between both protein pathways. Recently, synergy has been observed between Mcl-1 and HDM2 inhibitors. Towards the development of new anticancer drugs, we herein describe a polypharmacology approach for the dual inhibition of Mcl-1 and HDM2 by employing three densely functionalized isoxazoles, pyrazoles, and thiazoles as mimetics of key α-helical domains of their partner proteins.     

Technological learning and renewable energy costs: implications for US renewable energy policy

This paper analyzes the relationship between current renewable energy technology costs and cumulative production, research, development and demonstration expenditures, and other institutional influences. Combining the theoretical framework of ‘learning by doing’ and developments in ‘learning by searching’ with the fields of organizational learning and institutional economics offers a complete methodological framework to examine the underlying capital cost trajectory when developing electricity cost estimates used in energy policy planning models. Sensitivities of the learning rates for global wind and solar photovoltaic technologies to changes in the model parameters are tested. The implications of the results indicate that institutional policy instruments play an important role for these technologies to achieve cost reductions and further market adoption.     

Near-infrared spectrometry of microorganisms in liquid pharmaceuticals

Biotechnology and pharmaceutical research have created a number of new and potentially life-saving drugs. Many of these drugs are formulated as injectable products. Some drug products do not survive autoclaving or other means of terminal sterilization. An aseptic filling process is typically used to sterilize such products, but it is less reliable than autoclaving, making detection of unsterile units even more essential. Invasive microbiological methods and turbidimetry are currently employed as inspection techniques. These processes are time-consuming, destroy product, and may not detect low levels of contamination. Near-IR light scattering is proposed as a new method of determining low levels of contamination noninvasively and nondestructively. The method is used successfully in the current study to detect contamination by a species of yeast, mold, and bacteria in intact plastic infusion bags at levels as low as three colony-forming units per milliliter for yeast. By use of the near-IR method, each injectable unit can be evaluated with its integrity maintained, allowing the product to be dispensed or evaluated by another analytical method.