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1.
On the capacities of bipartite Hamiltonians and unitary gates 总被引:2,自引:0,他引:2
Bennett C.H. Harrow A.W. Leung D.W. Smolin J.A. 《IEEE transactions on information theory / Professional Technical Group on Information Theory》2003,49(8):1895-1911
We consider interactions as bidirectional channels. We investigate the capacities for interaction Hamiltonians and nonlocal unitary gates to generate entanglement and transmit classical information. We give analytic expressions for the entanglement generating capacity and entanglement-assisted one-way classical communication capacity of interactions, and show that these quantities are additive, so that the asymptotic capacities equal the corresponding 1-shot capacities. We give general bounds on other capacities, discuss some examples, and conclude with some open questions. 相似文献
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RM Campbell EP Heimer M Ahmad HG Eisenbeis TJ Lambros Y Lee RW Miller PR Stricker AM Felix 《Canadian Metallurgical Quarterly》1997,49(6):527-537
In the present study, human growth hormone-releasing factor (hGRF) and analogs were successfully pegylated at the carboxy-terminus using a novel solid- and solution-phase strategy. Following synthesis, these pegylated hGRF analogs were evaluated for in vitro and in vivo biological activity. Specifically, hGRF (1-29)-NH2, [Ala15]-hGRF (1-29)-NH2, [desNH2Tyr1, D-Ala2, Ala15]-hGRF(1-29)-NH2 and [His1, Val2, Gln8, Ala15, Leu27]-hGRF(1-32)-OH were each C-terminally extended using a Gly-Gly-Cys-NH2 spacer (previously demonstrated not to alter intrinsic biological activity), and then monopegylated via coupling to an activated dithiopyridyl-PEG reagent. PEG moieties of 750, 2000, 5000 or 10,000 molecular weight (MW) were examined to determine the effect of polymer weight on activity. Initial biological evaluations in vitro revealed that all C-terminally pegylated hGRF analogs retained high growth hormone (GH)-releasing potencies, regardless of the MW of PEG polymer employed. Two of these pegylated hGRF analogs, [desNH2Tyr1, D-Ala2, Ala15]-hGRF (1-29)-Gly-Gly-Cys(NH2)-S-Nle-PEG5000 and [His1, Val2, Gln8, Ala15, Leu27]-hGRF(1-32)-Gly-Cys(NH2)-S-Nle-PEG5000, were subsequently evaluated in both pig and mouse models and found to be highly potent (in vivo potency range = 12-55-fold that of native hGRF). Relative to their non-pegylated counterparts, these two pegylated hGRF analogs exhibited enhanced duration of activity. 相似文献
4.
ME Sutherlin I Nishimori T Caffrey EP Bennett H Hassan U Mandel D Mack T Iwamura H Clausen MA Hollingsworth 《Canadian Metallurgical Quarterly》1997,57(21):4744-4748
The levels of mRNA expression of three UDP-N-acetyl-alpha-D-galactosamine:polypeptide GalNAc N-acetylgalactosaminyltransferases (GalNAc-transferases) were quantified for human adenocarcinoma cell lines from pancreas, colon, stomach, and breast. Two of the GalNAc-transferases, GalNAc-T1 and GalNAc-T2, were expressed constitutively and at low levels in most or all cell lines examined. A third GalNAc-transferase, GalNAc-T3, was differentially expressed. Well-differentiated adenocarcinoma cell lines expressed high levels and moderately differentiated cell lines expressed lower levels of GalNAc-T3. Cell lines classified as poorly differentiated failed to express GalNAc-T3 mRNA at levels that could be detected by Northern blot analysis. Differential expression of the GalNAc-T3 protein was confirmed in these cell lines by Western blotting. We propose that glycosylation in tumor cell lines may be regulated in part by differential expression of GalNAc-transferases, and we suggest that GalNAc-T3 gene expression may be a molecular indicator of differentiated adenocarcinoma. 相似文献
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Three sporulation-specific genes (orfA, sigE, sigG) from clostridium acetobutylicum ATCC 824 are arranged in a cluster, encoding the putative sigma E-processing enzyme, sigma E, and sigma sigma G respectively. When they were transformed into Clostridium acetobutylicum while on a plasmid functional in this organism, transformants did not survive. Three kinds of recombinations were then attempted with nonreplicative plasmids: duplication of orfA and sigE, replacement of all of the three genes, and inactivation of orfA. While the wild-type strain ceased to grow and produce solvents in batch cultures after approximately 24 h, mutant strains were isolated that showed sustained growth for a much longer time and produced a threefold increase in acetone and butanol in test tube cultures. In addition, one of the derived strains showed a significantly higher growth rate. Features of the restriction maps of the recombinants did not correlate with expected maps, indicating possible complications occurring during the recombination events. 相似文献
7.
Occupational airway diseases are now receiving attention in industry, although study is hampered by a lack of readily-available data. The interpretation of the data that is available, and also of the root problems themselves, is itself a difficult problem. This paper has been written as a literature review which it is hoped that other researchers can take either as a starting point or as a refresher. 相似文献
8.
Larry Bennett 《Journal of Urban Affairs》1987,9(3):263-276
ABSTRACT: In 1983 Chicago elected its first black mayor, Harold Washington. During Washington's first term of office, his administration not only reordered municipal priorities in such a fashion as to benefit his core, minority voting constituency, but also defined a municipal agenda emphasizing greater attention to neighborhood needs and more open government. In 1984 an important neighborhood coalition, the Save Our Neighborhoods/Save Our City Coalition (SON/SOC), proposed a linked development policy to tap downtown investment for neighborhood projects. Although SON/SOC's proposal was compatible with the Washington neighborhood agenda, this mainly white organization and the Washington administration experienced considerable difficulty in forging a mutually acceptable proposal The linked development debate in Chicago demonstrates the salience of race, class-cultural factors, and alternative approaches to neighborhood mobilization as barriers to the development of progressive coalitions in city politics. 相似文献
9.
Mizumori Sheri J.; Rosenzweig Mark R.; Bennett Edward L. 《Canadian Metallurgical Quarterly》1985,99(2):220
The extent to which protein synthesis is involved in working memory was investigated with the protein synthesis inhibitor anisomycin (ANI). Male albino and Long-Evans rats were trained to perform accurately on a 12-arm radial maze when delays of 240 min were interposed between Choice 6 and Choice 7. Bilateral hippocampal cannulas were then implanted. Accuracy on Choices 7–22 was studied when ANI (80 μg/μl) or saline was injected either 30 min before Choice 1 or 5–20 min after Choice 6 in Exp I. Pretrial injection of ANI significantly impaired performance following the 240-min delay, whereas ANI injected during the delay had no such effect. In Exps II and III, the ANI-induced amnesia was replicated, and the temporal course of development of the amnesia was determined. Pretrial administration of ANI did not significantly affect retention after a 2-min delay but produced amnesia after delays of 15 min or longer. Data suggest that protein synthesis is important for the formation of temporary memories, provided the retention interval is long enough. It is suggested that working memory includes both short- and long-term components. Protein synthesis appears to be important for formation of the long-term component, but not the short-term component, of working memory. (31 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
10.
AS Astapchik EP Podvoisky IS Chebotko BM Khusid AG Merzhanov BB Khina 《Canadian Metallurgical Quarterly》1993,47(1):319-326
The labile protons of two 32-base-pair, four-arm models of immobile Holliday junctions have been studied by two-dimensional 1H nuclear magnetic resonance (NMR) spectroscopy. Overlap of resonances in the imino-imino region of two-dimensional nuclear Overhauser enhancement (NOE) spectra necessitates the use of a multi-pathway approach for obtaining sequence-specific assignments wherein all possible NOE connectivities to the labile protons are utilized, including those from the 2H of adenine, 5CH3 of thymine, and 5H of cytosine. Resonance assignments are obtained for all slowly exchanging imino and cytosine amino protons. Base-pairing up to and including the junction point is found in all four arms of both Holliday junctions. Several cross-arm NOE connectivities are identified and can be used to infer the geometry of the helical stacking domains. The two Holliday junctions studied, which differ only by the exchange of two base pairs at the branch point, appear to have opposite arm stacking geometries. These assignments form an important part of the critical background for detailed NMR analysis of Holliday junction structure and dynamics. 相似文献