Comparative studies of defect production in heavily doped silicon under fast electron irradiation at different temperatures

Production processes of electrically active defects in degenerate silicon subjected to 2.5 MeV electron irradiation at T = 4.2 K and T = 300 K have been studied. The production rates of primary and secondary defects in irradiated samples are analyzed on the basis of the known properties of radiation-produced defects in Si. It has been demonstrated that a striking difference in the production rates of electrically active defects in n- and p-Si under irradiation at cryogenic temperatures may be related to the different fate of Frenkel pairs in both materials. The production rate of primary defects in degenerate Si was found to be between 1.5 cm⁻¹ and 2 cm⁻¹.     

Effects of experimental endogenous hyperlipemia on circulating leukocytes and erythrocytes

Effects of hyperlipemia on circulating leukocytes and erythrocytes were studied in dogs which were given repeated, intravenous injections of a nonionic detergent, Triton WR-1339. Erythrocyte lipid concentrations increased from 3.6±0.9 mg/10¹⁰ cells in control animals to 9.3±1.5 mg in the hyperlipemic group. This increase was accompanied by a shift in the distribution of total fatty acids toward a higher percentage of saturated and monounsaturated acids. In contrast to the changes observed in erythrocytes, the leukocyte lipid content remained unaltered in dogs with serum cholesterol levels ranging from 500 to more than 2,000 mg/100 ml. Leukocyte counts rose whereas hematocrit values, hemoglobin concentrations, and erythrocyte counts decreased. Oxygen utilization studies showed no significant metabolic differences between leukocytes which were isolated from hyperlipemic or control animals. Circulating leukocytes in dogs with an endogenously induced hyperlipemia were shown therefore to maintain normal lipid concentrations and did not participate in lipophage formation, as reported for certain diet-induced lipemias.     

Lipid metabolism of acetate-1-14C by leukocytes from dogs fed an arteriosclerosis-inducing diet

Dogs were maintainedoon a control ration or on a semisynthetic diet, containing 5% cholesterol and 16% hydrogenated coconut oil, known to induce hyperlipemia and arteriosclerosis. Circulating leukocytes isolated from dogs fed the coconut oil containing diet were shown to incorporate 50% more radioactivity into lipids than control leukocytes when incubated with acetate-1-¹⁴C. This increase, expressed as dpm/mg of leukocyte DNA, was not specific for any particular lipid since the distribution of radioactivity between neutral lipids and phospholipids, as well as among their subfractions, was the same regardless of the diet fed. The labeling patterns observed suggest that leukocyte fatty acid synthesis from acetate occurs predominantly, and perhaps exclusively, by the chain elongation pathway.     

Thermal control of the liquid lithium divertor for NSTX

The liquid lithium divertor (LLD) to be installed in NSTX has four toroidal panels, each a conical section inclined at 22° like the previous graphite divertor tiles. Each LLD panel is a copper plate clad with 0.25 mm of stainless steel (SS) and a surface layer of flame sprayed molybdenum (Mo) that will host lithium deposited from an evaporator. LITER (evaporators) already used in NSTX will be upgraded for the LLD. Each has twelve 500 W cartridge heaters with thermocouples, 16 other thermocouples, and a channel for helium cooling. During LLD experiments, the LLD will be heated so that the lithium is just above its melting temperature. The length of each shot will be preset to prevent excessive evaporation of lithium from the LLD. This duration depends on the heat load and is likely to be in the range of less than a second to several seconds. Careful thermal control of the LLD is important to maximize the shot times and to guide operation of the LLD. This paper describes the layout of the LLD, its expected thermal performance, the control system, and supporting experiments and analysis. A companion paper in this conference, “Physics design requirements for the national spherical torus experiment liquid lithium divertor,” provides other information.     

The configuration of atomic defects as determined from scattering studies

Atomic defects such as vacancies and interstitials in crystalline solids produce elastic diffuse scattering of X-rays or neutrons. The distribution in reciprocal space of the diffuse scattering intensity contains very direct information about the atomic structure of point defects, and it sensitively shows the formation of defect clusters. Three domains of the scattering are distinguished: (a) scattering in the forward direction (small-angle scattering); (b) scattering between the Bragg reflections; and (c) scattering close to the Bragg reflections (Huang scattering). The specific features of the information obtained from measurements in the different domains are discussed. Experimental results on the structure of interstitials in metals have been obtained after low temperature electron irradiation of the fcc metals Al and Cu, bcc Mo, and hcp Zn. In other metals (Au, Nb, Cd, Mg) the agglomeration of interstitials was observed during electron irradiation at 5 K.     

Banning banking in EU emissions trading?

Admitting banking in emissions trading systems reduces overall compliance costs by allowing for inter-temporal flexibility: cost savings can be traded over time. However, unless individual EU Member States (MS) decide differently, the transfer of unused allowances from the period of 2005–2007 into the first commitment period under the Kyoto Protocol, i.e. 2008–2012, will be prohibited. In this paper, we first explore the implications of such a ban on banking when initial emission targets are lenient. This analysis is based on a simulation which was recently carried out in Germany with companies and with a student control group. The findings suggest that a EU-wide ban on banking would lead to efficiency losses in addition to those losses which arise from the lack of inter-temporal flexibility. Second, we use simple game-theoretic considerations to argue that, under reasonable assumptions, such a EU-wide ban on banking will be the equilibrium outcome. Thus, to avoid a possible prisoners’ dilemma, MS should have co-ordinated their banking decisions.     

Towards a medically approved technology for alginate-based microcapsules allowing long-term immunoisolated transplantation

The concept of encapsulated-cell therapy is very appealing, but in practice a great deal of technology and know-how is needed for the production of long-term functional transplants. Alginate is one of the most promising biomaterials for immunoisolation of allogeneic and xenogeneic cells and tissues (such as Langerhans islets). Although great advances in alginate-based cell encapsulation have been reported, several improvements need to be made before routine clinical applications can be considered. Among these is the production of purified alginates with consistently high transplantation-grade quality. This depends to a great extent on the purity of the input algal source as well as on the development of alginate extraction and purification processes that can be validated. A key engineering challenge in designing immunoisolating alginate-based microcapsules is that of maintaining unimpeded exchange of nutrients, oxygen and therapeutic factors (released by the encapsulated cells), while simultaneously avoiding swelling and subsequent rupture of the microcapsules. This requires the development of efficient, validated and well-documented technology for cross-linking alginates with divalent cations. Clinical applications also require validated technology for long-term cryopreservation of encapsulated cells to maintaining a product inventory in order to meet end-user demands. As shown here these demands could be met by the development of novel, validated technologies for production of transplantation-grade alginate and microcapsule engineering and storage. The advances in alginate-based therapy are demonstrated by transplantation of encapsulated rat and human islet grafts that functioned properly for about 1 year in diabetic mice.