Effects of antipsychotic treatment on polysomnographic measures in schizophrenia: a replication and extension

OBJECTIVE: The authors sought to replicate and extend previous observations of improvement in some EEG sleep measures during the course of antipsychotic treatment in schizophrenia patients. METHOD: Fourteen medication-free patients with schizophrenia underwent 2 nights of sleep EEG monitoring before and after 3-4 weeks of treatment with clinically determined doses of haloperidol or thiothixene. RESULTS: Measures of sleep continuity improved consistently. REM latency increased, although five of 14 patients continued to exhibit short REM latencies (less than 60 minutes). Stage 3 sleep increased during neuroleptic treatment, while stage 4 sleep did not change. CONCLUSIONS: These data demonstrate partial improvement of some but not all EEG sleep measures in schizophrenic patients through the course of neuroleptic treatment. They suggest that shortened REM latency and disturbed sleep continuity might represent reversible state abnormalities, while reduced slow-wave sleep may represent a more persistent trait abnormality in schizophrenia.     

Predicting Greek adolescents’ intentions to smoke: A focus on normative processes.

Objective: To examine the effects of normative influences on adolescent smoking in Greece, a country with weak social norms against smoking and relatively ineffective tobacco control policies. Design: A cross-sectional survey methodology was employed, and a representative sample of Greek high school students was recruited (N = 1,920, M age = 14 years). Main Outcome Measures: Normative beliefs, attitudes, perceived behavioral control, self-esteem, and intentions to smoke. Results: Multiple-regression and mediation analyses were conducted. The effects of public smoking on intentions to smoke were mediated by beliefs of perceived prevalence of smoking among peers, subjective norms, and situational temptations. Self-esteem significantly moderated the effects of subjective norms on intentions to smoke. Conclusions: Prosmoking norms in one’s environment become internalized into biased normative beliefs about smoking, and increase susceptibility to smoke under social pressure. The effect of subjective norms on intentions to smoke was stronger among adolescents with low self-esteem, suggesting that self-esteem may act as a vulnerability factor in the process of smoking initiation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sustained dapsone-induced remission of hypocomplementemic urticarial vasculitis--a case report

Hypocomplementemic urticarial vasculitis (HUV) is often misdiagnosed. The response to drug therapy may be unsatisfactory, and immunosuppressive therapy may be associated with significant side effects. A 35-year-old patient whose condition was resistant to cyclophosphamide, corticosteroids, pentoxyphylline, cyproheptadine, sulindac, and colchicine was maintained in remission with dapsone, which may be the drug of choice for HUV. Emphysema has been reported to complicate HUV, but this is the first account of vasculitis-related emphysema with no confounding history of tobacco smoke exposure. The relationship of proteolytic injury to the pulmonary and other manifestations is considered, as is the possible role for dapsone in reducing it.     

The assessment of diabetes knowledge and self-efficacy in a diverse population using Rasch measurement

The purpose of this research was to develop survey instruments to evaluate diabetes knowledge and self-efficacy in a diverse population, and investigate the psychometric properties of data obtained with these instruments using Rasch measurement. Two-hundred and fifty-five urban-dwelling participants with diabetes were recruited to complete surveys through independent interviews. To evaluate the association of health literacy on metabolic control, formal literacy and hemoglobin A1c fingerstick testing were performed. Rasch analysis of the data yielded item and person calibrations for self-efficacy and knowledge, with variable maps created to provide both norm and criterion-referenced interpretations. Knowledge scale person separation reliability was 0.50 and item separation reliability was 0.98; while self-efficacy scale person separation reliability was 0.72 with item separation reliability of 0.92. Statistically significant partial correlations were observed between knowledge and health literacy (r = 0.41, p<.001), and self-efficacy and hemoglobin A1c (r = -0.33, p<.001). However, there was no correlation between diabetes knowledge and hemoglobin A1c (r = 0.035, p = 0.29), or health literacy and A1c (r = 0.022, p = 0.36). Diabetes knowledge varied, with non-English speaking individuals having lower measures than English speakers (t(252) = -4.86, p<.001). Non-English speaking individuals also had lower self-efficacy measures than English speakers (t(251) = -2.68, p = .008). Current knowledge deficits and perceptions of self-management may be estimated visually through variable mapping, which may help in individualizing informational needs for people with diabetes.     

Understanding ‘local’ opposition to wind development in the UK: How big is a backyard?

In recognition of the environmental and economic threats posed by climate change; decisive steps are now being taken to stabilise greenhouse gas emissions. One sector receiving particular attention within the UK is that of electricity generation. As such, the government has introduced ambitious targets for increasing renewable generating capacity within the country. Wind turbines are expected to play a significant role in meeting these targets; however, despite high levels of support for the technology in principle, specific projects are often delayed or rejected on account of local opposition. This study aimed to establish how attitudes towards development might vary with respect to increasing distance from the identified sites. Participants were required to register their opinion towards development at a number of on- and off-shore locations in the UK. The results indicated that participants were most favourable to offshore development and least favourable to development at the identified sites. Attitudes to onshore development indicated that so long as a proposed location was anticipated to be ‘out of sight’ it was considered in relatively general terms. The results are discussed with reference to site visibility and landscape concerns and clearly support calls for a shift towards community-focussed development strategies.     

Identifying predictors of attitudes towards local onshore wind development with reference to an English case study

The threats posed by climate change are placing governments under increasing pressure to meet electricity demand from low-carbon sources. In many countries, including the UK, legislation is in place to ensure the continued expansion of renewable energy capacity. Onshore wind turbines are expected to play a key role in achieving these aims. However, despite high levels of public support for onshore wind development in principle, specific projects often experience local opposition. Traditionally this difference in general and specific attitudes has been attributed to NIMBYism (not in my back yard), but evidence is increasingly calling this assumption into question. This study used multiple regression analysis to identify what factors might predict attitudes towards mooted wind development in Sheffield, England. We report on the attitudes of two groups; one group (target) living close to four sites earmarked for development and an unaffected comparison group (comparison). We found little evidence of NIMBYism amongst members of the target group; instead, differences between general and specific attitudes appeared attributable to uncertainty regarding the proposals. The results are discussed with respect to literature highlighting the importance of early, continued and responsive community involvement in combating local opposition and facilitating the deployment of onshore wind turbines.     

Accentuation theory and the judgment of attitudes: Exploring possible limiting conditions.

To investigate the effects of Ss' attitudes and of response language on judgments of attitude statements, 62 university students rated 20 statements on the issue of the use of hallucinogenic drugs in terms of personal acceptability, and on 4 other rating scales. Two types of scales were used: A+ scales, where the antidrug end was marked by an evaluatively positive label and the prodrug end by an evaluatively negative label; and P+ scales, where the antidrug end was negatively labeled and the prodrug end positively labeled. In Condition 1, Ss were given only A+ scales; in Condition 2, only P+ scales; and in Conditions 3 and 4, 2 A+ and 2 P+ scales. Results confirm the accentuation theory prediction that "anti"-Ss should give more polarized ratings than "pro" Ss on A+ scales and less polarized ratings than "pro" Ss on P+ scales. This was so regardless of whether scale type was a between-Ss factor (comparison of Conditions 1 and 2) or, as in previous studies, a within-Ss factor (Conditions 3 and 4). Previous findings of a tendency for more anti ratings overall on A+ scales, and more pro ratings on P+ scales, were contradicted but it is argued that this may be due to Ss finding the statements mainly unacceptable. Other findings concern choice of adjectives to describe similar and dissimilar others. (French abstract) (26 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Photoinduced Shuttling Dynamics of Rotaxanes in Viscous Polymer Solutions

The effect of external friction, caused by medium viscosity, on the photoinduced translational motion in a rotaxane‐based molecular shuttle 1 is investigated. The shuttle is successfully operated in solutions of poly(methacrylonitrile) (PMAN) of different molecular weights in MeCN and PrCN. The viscosity of the medium is tuned by changing the PMAN concentration. The rheological behavior of the polymer solution gives insight into the structure of the polymer solution on the microscopic scale. In PrCN, the entanglement regime is reached at lower concentration than in MeCN. This is also reflected by the effect on the shuttling: in the PrCN/PMAN system, a larger viscosity effect is observed compared to MeCN/PMAN. The shuttle is found to be slowed down in the polymer solutions but is still active at high viscosities. The observed retardation effect on the kinetics of shuttling in MeCN/PMAN and PrCN/PMAN can be correlated to the PMAN concentration through the hydrodynamic scaling model. The Stokes–Einstein relationship proves inadequate to correlate the shuttling rates to macroscopic viscosity, but the dependence of the shuttling rate on the bulk viscosity fits well to a commonly observed power‐law relationship. The viscosity effect on the shuttling is found to be weak in all cases.     

Siblings of a child with cancer

A total of 21 healthy siblings were interviewed about their experiences when a brother or sister is diagnosed with cancer. Information about the illness, opinions about who should inform siblings, social support, specific worries and worst memories were studied, as well as perceptions of any differences in the way they were treated by their parents. A short General Impact Scale was developed to assess the extent to which the siblings felt their lives had been disrupted by the illness. Results on these measures were compared with scores on four dimensions of the Sibling Perception Questionnaire (Carpenter & Sahler 1991). Siblings who reported some positive effects as a consequence of the illness (they had become more empathic toward others, or valued life more) perceived their interpersonal relations to be more negatively affected, i.e. there were greater difficulties in their relationships with others especially their parents. Higher scores on communication were related to less of an impact of the illness on life generally. However, these siblings also reported heightened concerns that their brother or sister might die. The data suggested that siblings should have opportunities to talk about implications of the disease, especially worries about death, and more efforts should be made to prepare siblings for visits to hospital and seeing the sick child.     

Randomised placebo-controlled crossover trial on effect of inactivated influenza vaccine on pulmonary function in asthma

BACKGROUND: Despite current recommendations, many people with asthma do not receive annual vaccination against influenza, partly because of concern that vaccine may trigger exacerbations. Colds can trigger exacerbations, which may be mistaken for vaccine-related adverse events. We undertook a double-blind placebo-controlled multicentre crossover study to assess the safety of influenza vaccine in patients with asthma, with allowance for the occurrence of colds. METHODS: We studied 262 patients, aged 18-75 years, who recorded daily peak expiratory flow (PEF), respiratory symptoms, medication, medical consultations, and hospital admissions for 2 weeks before the first injection and until 2 weeks after the second injection. Order of injection (vaccine and placebo) was assigned randomly. There was an interval of 2 weeks between injections. The main outcome measure was an exacerbation of asthma within 72 h of injection (defined as a fall in PEF of >20%). FINDINGS: Among 255 participants with paired data, 11 recorded a fall in PEF of more than 20% after vaccine compared with three after placebo (McNemar's test p=0.06); a fall of more than 30% was recorded by eight after vaccine compared with none after placebo (binomial test p=0.008). However, when participants with colds were excluded, there was no significant difference in the numbers with falls of more than 20% between vaccine and placebo (six vs three; binomial test p=0.51), although the difference for PEF decreases of more than 30% approached significance (five vs none; binomial test, p=0.06). This association was confined to first-time vaccinees. INTERPRETATION: Our findings indicate that pulmonary-function abnormalities may occur as a complication of influenza vaccination. However, the risk of pulmonary complications is very small and outweighed by the benefits of vaccination.