The piscine bioconcentration characteristics of cyclic and linear oligomeric permethylsiloxanes

Using a conventional "resaturation" method whereby aquarium water was continuously passed through a column containing sand or fine glass beads coated with cyclic and linear permethylsiloxanes, their uptake levels by rainbow trout and fathead minnows have been compared. Because of the uncertainty associated with defining the actual aqueous concentrations of such poorly soluble substances, this study was focused on defining the "attainable uptake" levels from saturated solutions rather than precise definition of actual bioconcentration factor values. Although cyclic Me2SiO-oligomers accumulated to a greater extent in fish than did comparable linear oligomers, uptake decreased sharply with increasing molecular weight. Thus, in the cyclic series (Dx), order of magnitude decreases were observed for each incremental molecular weight increase; i.e., for the compounds D4, D5, and D6 uptake levels of approximately 200, 20 and 2 ppm, respectively, were observed. Uptake of D8 was below our detection limit of 300 ppb. In the linear series, uptake of the tetramer MD2M was an order of magnitude less than observed for D4 and little or no uptake (i.e., less than 0.5 ppm) was observed for MD3M, MD4M and MD7M. The branched oligomer M3T exhibited levels comparable to its unbranched isomer MD2M, while M4Q was more comparable to the D6 uptake of 1-2 ppm. Very similar uptake levels of D5 resulted with and without a surfactant, even though the surfactant afforded a 20-fold increase in the D5 content of the water. This suggests that bio-availability is defined by the amount present in true solution as individual molecules and is not affected by the presence of aggregates or micelles. The highly inverse relationship observed in this study between uptake and molecular weight is strongly supportive of earlier estimates of a limiting molecular weight of about 600. These findings also strongly contradict a recent Japanese study, which concluded that bioconcentration not only occurred but actually increased with molecular weight in a series of commercial polydimethylsiloxane fluids. Also contrary to a recently published inference of biotransformation in fish, no evidence for such phenomena was observed in this study.     

Physical and Sexual Intimate Partner Violence Among Women in Methadone Maintenance Treatment.

Although several studies have examined the relationship between intimate partner violence (IPV) and drug use among women in drug treatment programs, more information is needed to delineate differences, as a function of the specific drug used. Data from a random sample of 416 women attending methadone programs were analyzed to elucidate the differential associations between IPV and use of the following: marijuana only, cocaine only, heroin only, or cocaine and heroin. Prevalence of IPV among this sample far exceeded estimates from the general population. After adjusting for sociodemographic variables, use of cocaine only was significantly associated with an increased likelihood of experiencing IPV compared with no drug use. Similar results were found for women using both cocaine and heroin. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Early surgery in patients with mitral regurgitation due to flail leaflets: a long-term outcome study

BACKGROUND: The optimal timing for surgery in patients with mitral regurgitation is disputed. Because of the frequency of left ventricular dysfunction, which is difficult to predict, early surgery has been recommended, but its potential benefits have not been demonstrated. METHODS AND RESULTS: The outcomes of 221 patients (mean age, 65 +/- 13 years; 71% males) with flail leaflets diagnosed with two-dimensional echocardiography between 1980 and 1989 who were eligible for operation were analyzed. Group I comprised 63 patients who had early mitral valve surgery (within 1 month after diagnosis). Group II comprised 158 patients initially treated conservatively (80 of whom were operated on later). Group I patients were younger (P=.009), had more symptoms (P<.0001), and were more frequently in atrial fibrillation (P=.023) than group II patients. There was no difference in ejection fraction between the groups. The early surgery strategy was followed by an improved overall survival rate (P=.028) and a lower incidence of cardiovascular deaths (P=.025), congestive heart failure (P=.046), and new chronic atrial fibrillation (P=.032), as confirmed by multivariate analysis (adjusted risk ratios of 0.31, 0.18, 0.38, and 0.05, respectively; all P<.02). CONCLUSIONS: In patients with mitral regurgitation due to flail leaflets, the strategy of early surgery versus conservative management is associated with an improved long-term survival rate, decreased cardiac mortality, and decreased morbidity after diagnosis. This outcome advantage suggests that early surgery is a reasonable treatment option to be considered in low-risk candidates with repairable valves and severe mitral regurgitation.     

Children's construction of horizontals, verticals, and diagonals: An operational explanation of the "oblique effect."

Used a computer-based task to investigate the problem that young children have in constructing diagonals. The computer made it feasible to change how lines of different orientations had to be formed. It was predicted that if diagonals are difficult to construct because of the operations required to conceptualize them, then changing how they had to be formed might make it possible for children to construct diagonals better than horizontals and verticals. 20 5-yr-olds, 20 8-yr-olds, and 20 undergraduates attempted to construct horizontal, vertical, 45° left diagonal, and 45° right diagonal lines in either horizontal/vertical-easy or diagonal-easy configurations of the apparatus. Results support the operational explanation of the oblique effect. The 5-yr-olds performed in accordance with the configuration of the drawing system. On the whole, they could not make diagonals in the horizontal/vertical-easy configuration, thus demonstrating the oblique effect. When diagonals were made easy to produce, 5-yr-olds could form them but had difficulty with horizontals and verticals, indicating a nonoblique effect in the diagonal-easy configuration. There was only an oblique effect with the 8-yr-olds. Undergraduates made virtually no errors on any of the lines. Findings confirm the claim that the difficulty that the 5-yr-olds had was in combining separate spatial components. (20 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of combined lead and cadmium exposure: Changes in schedule-controlled responding and in dopamine, serotonin, and their metabolites.

Adult male rats were maintained on 1 of 4 ad-lib diets: Group Control-Diet received a normal laboratory diet that contained no added chemicals; Group Lead-Diet received a diet containing 500 ppm (parts per million) lead; Group Cadmium-Diet received a diet containing 100 ppm cadmium; and Group Lead-Cadmium Diet received a diet containing both 500 ppm lead and 100 ppm cadmium. After 60 days of exposure to their respective diets, animals were placed on restricted diets (15 g/day) of the identical food received during the exposure period. Each animal was trained to lever press on an FI 1-min schedule for 21 sessions (1 session/day). The results of schedule training showed that lead alone or cadmium alone was associated with increased lever pressing relative to control diet. However, when lead and cadmium were exposed jointly, performance was not significantly different from control performance. Similar attenuation of effects were observed for central neurotransmitter functions. Specifically, disturbances in dopamine and serotonin turnover that were produced by lead alone were attenuated by the cotreatment of cadmium and lead. Possible accounts of the apparent antagonism between cadmium and lead are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A robust 43-GHz VCO in CMOS for OC-768 SONET applications

In this paper, we present a 43-GHz LC-VCO in 0.13-/spl mu/m CMOS for use in SONET OC-768 optical networks. A tuned output buffer is used to provide 1.3 V/sub p-p/ (single-ended) into a 90-fF capacitive load as is required when the VCO is used in typical clock and data recovery (CDR) circuits. Phase noise is -90 dBc/Hz at a 1-MHz offset from the carrier; this meets SONET jitter specifications. The design has a tune range of 4.2%. The VCO, including output buffers, consumes 14 mA from a 1-V supply and occupies 0.06 mm/sup 2/ of die area. Modern CMOS process characteristics and the high center frequency of this design mean that the tank loss is not dominated by the integrated inductor, but rather by the tank capacitance. An area-efficient inductor design that does not require any optimization is used.     

Structure-activity relationship homology (SARAH): a conceptual framework for drug discovery in the genomic era

Extension of the traditional pharmacological approach of protein target classification to whole target systems has the potential to relate elements of protein sequence to the structure-activity relationship (SAR) of small molecules that can modulate protein action. Grouping potential drug discovery targets into families based on the relatedness of their SAR provides a means to translate the information from genome-sequencing efforts into knowledge that will aid in the discovery of drugs.     

The context of aggressive behavior in marriage: A longitudinal study of newlyweds.

Under what circumstances are spouses more or less likely to engage in aggressive behaviors? To address this question, the current study drew on multiple longitudinal assessments of 1st-married newlyweds to examine correlates of within-subject variability in aggressive behavior. Controlling for marital satisfaction, the authors found that spouses were more likely to engage in physical aggression at times when they engaged in higher levels of psychological aggression. Additionally, husbands reporting higher levels of chronic stress were more likely to engage in physical aggression overall and were more likely to engage in physical aggression when they were experiencing higher than average levels of acute stress. These results highlight how demands and supports in the context external to a marriage may affect processes within the marriage. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The design, synthesis and transmembrane transport studies of a biomimetic sterol-based ion channel

A model sterol-based ion channel was rationally designed and synthesized. The potential ion channel is comprised of a tartrate-derived crown ether to which six steroids are appended. Macromolecule 1a was incorporated into phospholipid vesicles and shown to facilitate the transmembrane transport of sodium and lithium ions using alkali metal NMR spectroscopy.     

Silicon multichip modules: evolving a high performance technology from low-end applications

Recently, silicon-on-silicon multichip modules (MCMs) have shifted away from high performance digital applications toward low-end, cost driven products with a primary emphasis on volume production. This shift has been accompanied by changes in the physical structure of the MCM interconnections. Cost reduction has driven them toward thinner metal and dielectric layers, and wherever possible toward the use of fewer layers. It has also fundamentally changed the flip-chip attachment process. We are now reexamining the effect these changes are having on the performance characteristics of the technology, and the role of MCMs in systems packaging.