全文获取类型
收费全文 | 3153篇 |
免费 | 21篇 |
国内免费 | 6篇 |
专业分类
电工技术 | 22篇 |
综合类 | 4篇 |
化学工业 | 145篇 |
金属工艺 | 6篇 |
机械仪表 | 19篇 |
建筑科学 | 39篇 |
矿业工程 | 2篇 |
能源动力 | 11篇 |
轻工业 | 61篇 |
水利工程 | 14篇 |
石油天然气 | 4篇 |
无线电 | 111篇 |
一般工业技术 | 145篇 |
冶金工业 | 2526篇 |
原子能技术 | 2篇 |
自动化技术 | 69篇 |
出版年
2023年 | 4篇 |
2022年 | 7篇 |
2021年 | 4篇 |
2020年 | 7篇 |
2019年 | 4篇 |
2018年 | 11篇 |
2017年 | 5篇 |
2016年 | 10篇 |
2015年 | 9篇 |
2014年 | 12篇 |
2013年 | 43篇 |
2012年 | 15篇 |
2011年 | 29篇 |
2010年 | 26篇 |
2009年 | 16篇 |
2008年 | 33篇 |
2007年 | 38篇 |
2006年 | 32篇 |
2005年 | 22篇 |
2004年 | 18篇 |
2003年 | 20篇 |
2002年 | 23篇 |
2001年 | 14篇 |
2000年 | 14篇 |
1999年 | 105篇 |
1998年 | 800篇 |
1997年 | 447篇 |
1996年 | 327篇 |
1995年 | 197篇 |
1994年 | 153篇 |
1993年 | 163篇 |
1992年 | 26篇 |
1991年 | 37篇 |
1990年 | 35篇 |
1989年 | 37篇 |
1988年 | 47篇 |
1987年 | 34篇 |
1986年 | 43篇 |
1985年 | 35篇 |
1984年 | 9篇 |
1983年 | 12篇 |
1982年 | 6篇 |
1981年 | 14篇 |
1980年 | 27篇 |
1979年 | 8篇 |
1978年 | 15篇 |
1977年 | 46篇 |
1976年 | 112篇 |
1975年 | 9篇 |
1973年 | 5篇 |
排序方式: 共有3180条查询结果,搜索用时 15 毫秒
1.
Dr. Laurent David Dr. Mark Wenlock Dr. Patrick Barton Dr. Andreas Ritzén 《ChemMedChem》2021,16(17):2669-2685
Chameleonic properties, i. e., the capacity of a molecule to hide polarity in non-polar environments and expose it in water, help achieving sufficient permeability and solubility for drug molecules with high MW. We present models of experimental measures of polarity for a set of 24 FDA approved drugs (MW 405-1113) and one PROTAC (MW 1034). Conformational ensembles in aqueous and non-polar environments were generated using molecular dynamics. A linear regression model that predicts chromatographic apparent polarity (EPSA) with a mean unsigned error of 10 Å2 was derived based on separate terms for donor, acceptor, and total molecular SASA. A good correlation (R2=0.92) with an experimental measure of hydrogen bond donor potential, Δlog Poct-tol, was found for the mean hydrogen bond donor SASA of the conformational ensemble scaled with Abraham's A hydrogen bond acidity. Two quantitative measures of chameleonic behaviour, the chameleonic efficiency indices, are introduced. We envision that the methods presented herein will be useful to triage designed molecules and prioritize those with the best chance of achieving acceptable permeability and solubility. 相似文献
2.
3.
4.
JB Kamien WK Bickel BJ Smith GJ Badger JR Hughes 《Canadian Metallurgical Quarterly》1997,58(4):983-991
The percentage of long-term survivors after intensive chemotherapy and the outcome of MDS patients who achieve partial remission (PR) with intensive chemotherapy (IC) are not known. Between 1981 and 1996 we treated 99 patients with de novo MDS who had high-risk MDS or progression to AML, with IC. 41 (41%) achieved CR, 16 (16%) achieved partial remission (PR), 26 (26%) had failure, and 16 (16%) died in aplasia. Eight of the patients who achieved CR were autografted, three were allografted and the remaining cases received moderate consolidation chemotherapy. After IC, the 16 PR patients fulfilled the criteria for RA in 15 cases and CMML in one case. Median PR duration was 17 months, and three PR were > 3 years (39, 50+, 82+ months). Median actuarial survival of patients who achieved PR and CR was 18 months and 20 months from the onset of IC, respectively (difference not significant). Of the 71 patients treated before 1993, with sufficient follow-up, 10 (14%) had survived > 4 years (long-term survivors). Four of them were alive in first CR after 49+ to 110+ months and probably cured, two were alive in PR after 50+ and 82+ months and four had died after 49-78 months. Long-term survivors were characterized by a significantly higher incidence of RAEB-T at diagnosis, and with normal or favourable cytogenetic findings. In patients with RAEB-T at diagnosis included before 1993, 8/23 (35%) cases who had no unfavourable karyotype had survived > 4 years. Our findings suggest that MDS patients who achieve PR with IC, and not only those who achieve CR, can benefit from this type of treatment. The percentage of long-term survivors remains low, however, and is almost restricted to patients with RAEB-T at diagnosis and no unfavourable karyotype. 相似文献
5.
6.
7.
We have compared the duration of motor block produced by four local anaesthetics administered into a chronically implanted subarachnoid catheter in rabbits. Each group (n = 6) received four different doses of amethocaine, bupivacaine, lignocaine or procaine, and the duration of the resulting motor block was assessed. Dose-response curves were plotted for each drug. As a measure of activity of the anaesthetics, we used the dose of each drug required to produce block of 60-min duration (D60 min) and the correlation between D60 min and different drug properties was examined. An inverse linear correlation (r = 0.995; P < 0.01) was observed between log D60 min and the log of the partition coefficient of the local anaesthetics. No correlation was found between the effect and degree of protein binding, pKa or molecular weight. These results suggest that, in spinal anaesthesia, the partition coefficient could be used as a predictor of the duration of anaesthetic action. 相似文献
8.
Bound-state beta decay of highly ionized atoms 总被引:1,自引:0,他引:1
9.
Douglas A SchwerJohn E Tolsma William H Green JrPaul I Barton 《Combustion and Flame》2002,128(3):270-291
A method of updating and reusing legacy FORTRAN codes for combustion simulations is presented using the DAEPACK software package. The procedure is demonstrated on two codes that come with the CHEMKIN-II package, CONP and SENKIN, for the constant-pressure batch reactor simulation. Using DAEPACK generated code, analytical derivative calculations, sparsity pattern information, and hidden discontinuity information can be obtained for the models of interest. This information can be easily integrated with different solvers giving the modeler great flexibility in selecting the best solution procedure. Using the generated code, the CONP code was connected to three different solvers, and the SENKIN code was connected to two different solvers. The effect of model formulation, analytical derivatives, sparsity, and sensitivity equation solution method were analyzed for three large kinetic mechanisms for methane, acetylene, and n-heptane. For the n-heptane model, with 544 species and 2446 reactions, a factor of 10-speed improvement over the original solution procedure was found using analytical derivatives and sparse linear algebra. For sensitivity calculations, for a small number of parameters, a factor of 55 improvement over the original solution procedure was found for the n-heptane problem. Upon closer examination of results, no one method is found to always be superior to other methods, and selection of the appropriate solution procedure requires an examination of the specific kinetic mechanism, which is easily conducted using DAEPACK generated code. 相似文献
10.
A theory is presented that explains how the visual system infers the lightness, opacity, and depth of surfaces from stereoscopic images. It is shown that the polarity and magnitude of image contrast play distinct roles in surface perception, which can be captured by 2 principles of perceptual inference. First, a contrast depth asymmetry principle articulates how the visual system computes the ordinal depth and lightness relationships from the polarity of local, binocularly matched image contrast. Second, a global transmittance anchoring principle expresses how variations in contrast magnitudes are used to infer the presence of transparent surfaces. It is argued that these principles provide a unified explanation of how the visual system computes the 3-D surface structure of opaque and transparent surfaces. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献