Cerebral microbleeds and cognitive decline in a hemodialysis patient: Case report and review of literature

Cerebral microbleeds (CMBs) are small hemosiderin deposits indicative of prior cerebral microscopic hemorrhage and previously thought to be clinically silent. Recent population‐based cross‐sectional studies and prospective longitudinal cohort studies have revealed association between CMB and cognitive dysfunction. In the general population, CMBs are associated with age, hypertension, and cerebral amyloid angiopathy. In the chronic kidney disease (CKD) population, diminished estimated glomerular filtration rate has been found to be an independent risk factor for CMB, raising the possibility that a uremic milieu may predispose to microbleeds. In the end‐stage renal disease (ESRD) population on hemodialysis, the incidence of microbleeds is significantly higher compared with a control group without history of CKD or stroke. We present an ESRD patient on chronic hemodialysis with a history of gradual cognitive decline and progressive CMBs. Through this case and literature review, we illustrate the need to develop detection and prediction models to treat this frequent development in ESRD patients.     

Development and Performance of Crystallization with Additives Applied on Different Milk Samples

Crystallization with additives is developed on milk samples from different processing treatments. Performance tests are carried out based on structure analysis of the crystallization patterns. Crystallization with milk as additive is applied following changes in milk after different processing treatments. When an aqueous cupric chloride dihydrate solution crystallizes in the presence of milk as additive, specific patterns emerge, which can be evaluated by image analysis. Milk samples were heated and homogenized in a pilot plant and characterized by various parameters. Furthermore, milk samples from the market were tested. Patterns from milk after heat treatment and homogenization are significantly different from those derived from untreated milk. The experiments could be reproduced for other milk samples, on different days and in another laboratory.     

Security requirement analysis of business processes

Economic globalization leads to complex decentralized company structures calling for the extensive use of distributed IT-systems. The business processes of a company have to reflect these changes of infrastructure. In particular, due to new electronic applications and the inclusion of a higher number of—potentially unknown—persons, the business processes are more vulnerable against malicious attacks than traditional processes. Thus, a business should undergo a security analysis. Here, the vulnerabilities of the business process are recognized, the risks resulting from the vulnerabilities are calculated, and suitable safeguards reducing the vulnerabilities are selected. Unfortunately, a security analysis tends to be complex and affords expensive security expert support. In order to reduce the expense and to enable domain experts with in-depth insight in business processes but with limited knowledge about security to develop secure business processes, we developed the framework MoSS_BP facilitating the handling of business process security requirements from their specification to their realization. In particular, MoSS _BP provides graphical concepts to specify security requirements, repositories of various mechanisms enforcing the security requirements, and a collection of reference models and case studies enabling the modification of the business processes. In this paper, the MoSS _BP -framework is presented. Additionally, we introduce a tool supporting the MoSS_BP-related security analysis of business processes and the incorporation of safeguards. This tool is based on object-oriented process models and acts with graph rewrite systems. Finally, we clarify the application of the MoSS_BP-framework by means of a business process for tender-handling which is provided by anonymity-preserving safeguards. Peter Herrmann studied computer science at the University of Karlsruhe, Germany (diploma in 1990). Afterwards, he worked as a Ph.D. student (doctorate in 1997) and postdoctoral researcher in the Computer Networks and Distributed Systems Group of the Computer Science Department at the University of Dortmund, Germany. Since 2005 he is a full professor for formal methods at the Department for Telematics of the Norwegian University of Science and Technology (NTNU) in Trondheim, Norway. His research interests include the formal-based development of networked systems and the engineering of distributed services. Moreover, he is interested in security and trust aspects of component structured distributed software. Gaby Herrmann studied computer science at the University of Karlsruhe, Germany (diploma in 1991). Afterwards, she worked as a researcher in the Communication Group and the Information Systems Group at University of Duisburg-Essen (Doctorate in 2001, topic: security of business processes). Since 2000 she works as executive secretary at the Department of Economics, Business Studies and Computer Sciences at the same university.     

Citation analysis and peer ranking of Australian social science journals

Citation analyses were performed for Australian social science journals to determine the differences between data drawn from Web of Science and Scopus. These data were compared with the tier rankings assigned by disciplinary groups to the journals for the purposes of a new research assessment model, Excellence in Research for Australia (ERA), due to be implemented in 2010. In addition, citation-based indicators including an extended journal impact factor, the h-index, and a modified journal diffusion factor, were calculated to assess whether subsequent analyses influence the ranking of journals. The findings suggest that the Scopus database provides higher number of citations for more of the journals. However, there appears to be very little association between the assigned tier ranking of journals and their rank derived from citations data. The implications for Australian social science researchers are discussed in relation to the use of citation analysis in the ERA.     

Inactivation of Staphylococcus hyicus lipase by hexadecylsulfonyl fluoride: evidence for an active site serine

The Staphylococcus hyicus lipase is an acyl hydrolase with broadsubstrate specificity including neutral glycerides and phospholipids.To obtain further insight into the mechanism of action of thisenzyme, we tested several sulfonyl fluorides as active site-directedinhibitors. The enzyme is resistant to the well-known serineprotease/esterase inhibitor phenylmethanesulfonyl fluoride (PMSF),but is rapidly inactivated by hexadecylsulfonyl fluoride. Thekinetics of inactivation were studied in Triton X-100 micelles.Inactivation is fast and the rate of inactivation is constantover the pH range where this lipase is active. Metal ions likeCa²⁺ and Sr²⁺ do not appreciably influence the rate of inactivation,although the enzymatic activity is significantly increased,suggesting a structural role for these ions. The S.hyicus lipasecontains a consensus sequence G-H/Y-S-X-G. Substitution by site-directedmutagenesis of this serine (Ser369) by a cysteine resulted ina mutant with only 0.2% residual activity. The activity of thismutant could not be inhibited with water-soluble sulfhydrylreagents either in the presence or absence of Triton X-100 micelles.In the presence of Triton X-100 micelles, inactivation of themutant occurred with 4-nitrophenylhexadecyl disulfide (t_1/2= 125 min) while the wild-type enzyme does not react at all.We conclude that Ser369 is the active site residue and thatin water this residue is inaccessible. Only after interfacialactivation Ser369 (or Cys369) becomes exposed and reacts withirreversible inhibitors.     

Fragmentation mechanisms based on single drop steam explosion experiments using flash X-ray radiography

Flash X-ray and high-speed regular photography were used to investigate the fragmentation processes during the vapor explosion of single drops of molten metal immersed in water. For relatively low ambient flow velocities (< 5 m/s), a comparison of the breakup of hot and cold drops shows that whereas cold drops breakup due to the stripping of fragments by the relative flow, the fragmentation of a hot drop is dominated by the growth and collapse of a vapor bubble. X-ray radiographs show during the growth of the bubble, that fine filaments of metal protrude from the drop and the drop surface becomes highly convoluted. Using a simple model for the bubble dynamics, an estimate of the energy budget shows that the majority (about 80%) of the thermal energy transfer occurs during bubble collapse. For hot drops at higher flow velocities (> 45 m/s), vapor bubble growth is diminished and high-speed motion of vapor within the bubble leads to an enhanced fragmentation rate.     

Detonation propagation through a nonuniform layer of hydrogen-oxygen in a narrow channel

Experiments were carried out to study detonation propagation through a nonuniform layer of stoichiometric hydrogen-oxygen in a narrow channel. Premixed stoichiometric hydrogen-oxygen was injected through a series of 1.3 mm diameter, 4.8 mm spaced holes into a 7 mm wide optically accessible channel initially filled with an inert gas. A Chapman-Jouguet detonation wave was transmitted into the test section from a pre-detonator of equal height. The height of the layer was varied by changing the time of hydrogen-oxygen injection relative to the arrival-time of the detonation wave. Schlieren photography was used to record the progression of the detonation wave. Soot foils mounted to the back window, were used to record the detonation cellular structure and visualization of the soot incandescence provided tracking of the reaction zone. With the channel initially filled with argon, detonation propagation was only possible when the layer height accommodated at least 8–11 detonation cells. Detonation propagation was not possible when the channel initially contained nitrogen, or carbon dioxide, indicating strong mixing with the injected premixed hydrogen-oxygen. Numerical simulations confirmed the strong mixing between the injected premixed hydrogen-oxygen with the prefilled inert gas. The simplified mixing condition, i.e., injection of premixed hydrogen-oxygen, provides a unique data set for numerical code validation and verification for a linear RDE geometry.     

The role of shock-flame interactions on flame acceleration in an obstacle laden channel

Flame acceleration was investigated in an obstructed, square-cross-section channel. Flame acceleration was promoted by an array of top and bottom surface mounted obstacles that were distributed along the entire channel length at an equal spacing corresponding to one channel height. This work is based on a previous investigation of the effects of blockage ratio on the early stage of flame acceleration. This study is focused on the later stage of flame acceleration when compression waves, and eventually a shock wave, form ahead of the flame. The objective of the study is to investigate the effect of obstacle blockage on the rate of flame acceleration and on the final quasi-steady flame-tip velocity. Schlieren photography was used to track the development of the shock-flame complex. It was determined that the interaction between the flame front and the reflected shock waves produced from contact of the lead shock wave with the channel top, channel bottom, and obstacle surfaces govern the late stage of flame acceleration process. The shock-flame interactions produce oscillations in the flame-tip velocity similar to that observed in the early stage of flame acceleration, but only much larger in magnitude. Eventually the flame achieves a globally quasi-steady velocity. For the lowest blockage obstacles, the velocity approaches the speed of sound of the combustion products. The final quasi-steady flame velocity was lower in tests with the higher obstacle blockage. In the quasi-steady propagation regime with the lowest blockage obstacles, burning pockets of gas extended only a few obstacles back from the flame-tip, whereas burning pockets were observed further back in tests with the higher obstacle blockage.