An accurate block-trimming device for ultramicrotomy of selected cells

A small instrument is described which is operated on the stage of a light microscope to trim resin-embedded specimens to precise levels for subsequent ultramicrotomy and to cut thin pilot sections for light microscopy. The operating procedure and examples of results are given.     

Electron Thermalization in Metallic Islands Probed by Coulomb Blockade Thermometry

We describe a systematic series of experiments on thermalization of electrons in lithographic metallic thin films at millikelvin temperatures using Coulomb blockade thermometry (CBT). Joule dissipation due to biasing of the CBT sensor tends to drive the electron system into non-equilibrium. Under all experimental conditions tested, the electron-electron relaxation is fast enough to ensure thermal electron distribution, which is also in agreement with the theoretical arguments we present. On the other hand, poor electron-phonon relaxation plays a dominant role in lifting the electron temperature above that of the bath. From a comparison of the results with the theoretical current-voltage characteristics of the thermometers we precisely determine the electron-phonon coupling constant for the common metals used. Our experiments show that it is a formidable task to attain thermal equilibrium with the bath using single-electron devices under non-zero bias conditions at 20–50 mK temperatures that are typically encountered in experiments. The conclusion concerning Coulomb blockade thermometry is more optimistic and two-fold: (1) One can now correct the errors due to bias heating in a satisfactory manner based on known material properties and the size of the metal films in the sensor. (2) Reliable thermometry down to 20 mK requires islands whose volumes are >10^?15 m³, which is still acceptable both from the parameter (capacitance) and fabrication points of view.     

Automatic generation of IDEF0 models

This paper looks into a new area for knowledge-based system application, that of manufacturing modelling. Manual generation of IDEF0 models of manufacturing systems is time-consuming and inconsistent. However, the process can be automated to improve timeliness and consistency. In this paper, a knowledge-based manufacturing modelling system for the automatic generation of IDEF0 models is proposed. The system will not only greatly reduce the IDEF0 modelling time but will also eliminate the inconsistency problem of conventional IDEF0 modelling systems. The paper explains the knowledge-based approach and identifies the kinds of domain knowledge that are required for the construction of the knowledge-based manufacturing modelling system.     

Homophily of Network Ties and Bonding and Bridging Social Capital in Computer-Mediated Distributed Teams

This research studied homophily of network ties in distributed teams in both task-related instrumental networks and non-task related expressive networks. Homophily of network ties was examined in terms of demographic and social characteristics, including gender, race, geographic location, and group assignment. Social network data were collected from 32 students enrolled in a distance learning class from two universities. MQAP regression analysis showed that homophily in gender and in race had no significant impact on the development of either instrumental or expressive ties. In instrumental networks, both homophily in group assignment and in location had significant impact on the development of network ties. In expressive networks, homophily in location had significant impact on the development of network ties, but the impact of homophily in group membership was only marginally significant. Further analysis of bonding ties with people of the same group and bridging ties with people from different groups showed that bonding social capital can exert significant influence on performance.     

Part II: An example of the use of the comsis software: simulation of an optical network which uses wavelength multiplexing,fsk modulation format and direct detection

This second article deals with using the Comsis software for a particular application. Simulation is used to determine the maximum channel density in presence of crosstalk. In a first part, the modelling of the system is described. The simulation parameters of different optical elements are given. The results show that in the case of channels modulated at 500 Mbitls using fsk modulation format, and a direct detection operation at 1,5 μm, a minimum spacing of 6 GHz can be obtained with a 2 dB penalty. Thus if only the bandwidth of the erbium doped fibre amplifier is taken into account, the maximum number of channels which can be used is 250. However if the fsr (free spectral range) of optical filter is taken into account, the maximun number of channels is limited to 30.     

Citrullinemia: management and clinical course. Apropos of a familial case

The authors report two cases of citrullinemia in siblings which add to 68 observations from the literature. They overview the clinical presentation, diagnosis and therapeutic management of the disease. The prognosis of severe neonatal form remains poor but an early adequate management may contribute to an acceptable outcome.     

Improved cellulase production by stable Clostridium cellulolyticum mutants

Methods for the production of mutants of the cellulase producer Clostridium cellulolyticum ATCC 35319 were examined using an agar plate screening technique. Spontaneous and UV light-induced mutants were isolated, some of which exhibited a high level of both endoglucanase and exoglucanase activities as assayed using CMC (carboxymethyl cellulose) and PNPCb (paranitrophenyi-β-cellobioside) respectively. The volumetric enzyme activities were up to 2.5 times those of the wild strain.     

In Google We Trust: Users' Decisions on Rank, Position, and Relevance

An eye tracking experiment revealed that college student users have substantial trust in Google's ability to rank results by their true relevance to the query. When the participants selected a link to follow from Google's result pages, their decisions were strongly biased towards links higher in position even if the abstracts themselves were less relevant. While the participants reacted to artificially reduced retrieval quality by greater scrutiny, they failed to achieve the same success rate. This demonstrated trust in Google has implications for the search engine's tremendous potential influence on culture, society, and user traffic on the Web.