CTLA4 mediates antigen-specific apoptosis of human T cells

The regulation of T cell-mediated immune responses requires a balance between amplification and generation of effector function and subsequent selective termination by clonal deletion. Although apoptosis of previously activated T cells can be induced by signaling of the tumor necrosis factor receptor family, these molecules do not appear to regulate T-cell clonal deletion in an antigen-specific fashion. We demonstrate that cross-linking of the inducible T-cell surface molecule CTLA4 can mediate apoptosis of previously activated human T lymphocytes. This function appears to be antigen-restricted, since a concomitant signal T-cell receptor signal is required. Regulation of this pathway may provide a novel therapeutic strategy to delete antigen-specific activated T cells.     

Toxicity of nitro compounds fromLotus pedunculatus to grass grub (Costelytra zealandica) (Coleoptera: Scarabaeidae)

Crude extracts of root of the forage legumesLotus pedunculatus andCoronilla varia (crownvetch) were toxic when administered orally to 3rd instarCostelytra zealandica larvae. A group of 3-nitropropanoyl-d-glucopyranoses was isolated from active fractions of the crude extracts. These toxins, some of which were already known fromC. varia, have not previously been reported fromL. pedunculatus. The compounds were present in root tissue of this species at a concentration of about 1% dry weight. They include the triester karakin and the diesters coronarian and cibarian, all of which were toxic to larvae ofC. zealandica at levels which could account fully for the activity of the crude extracts.     

Data-Intensive Computing in the 21st Century

The deluge of data that future applications must process—in domains ranging from science to business informatics—creates a compelling argument for substantially increased R&D targeted at discovering scalable hardware and software solutions for data-intensive problems.     

Optical parametric amplification of femtosecond pulses tunable from the blue to the infrared with microjoule energies

A white-light continuum is used to seed a two-stage optical parametric amplifier pumped by the second harmonic of a regeneratively amplified Ti:sapphire laser system operating at 824 nm. Microjoule energies are achieved in the signal branch, which is tunable from 472 to 785 nm. Near-transform-limited sub-200-fs pulses are attainable over the vast majority of the tuning range.     

Predicting Improvement After First-Grade Reading Difficulties: The Effects of Oral Language, Emergent Literacy, and Behavior Skills.

This study investigated the role of early literacy and behavioral skills in predicting the improvement of children who have experienced reading difficulties in 1st grade. The progress of 146 low-income children whose reading scores in 1st grade were below the 30th percentile was examined to determine (a) how the poorest readers in 1st grade progressed in reading achievement through 4th grade and (b) which emergent literacy and behavioral skills measured in kindergarten predicted differential 4th grade outcomes. Results indicated that the divergence between children who improved and those who did not was established by the end of 2nd grade. Further, individual linguistic skills and behavioral attributes measured in kindergarten contributed substantively to this difference. Implications for intervention timing and educational policy are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Processing of Cassava to Produce Ethanol – Effect of Raw Material Preparation

The effect of disintegration severity on starch hydrolysis and ethanol production from cassava roots and stems has been evaluated. It was found that a considerable fraction of the starch in the roots was made available for hydrolysis with relatively crude processing; all such material was readily fermented. To achieve a very high fermentables yield, either very intensive processing or, preferably, a two stage process, with the second stage being applied only to the oversize material, is required. Whether it is economically viable to process the oversize material further depends on a number of site-specific factors. The two stage option appears the more attractive alternative especially in small to medium size cassava to ethanol plants because of the need to minimise power requirements and thereby steam usage.     

Paint deposition modeling for trajectory planning on automotive surfaces

This research is focused on developing trajectory planning tools for the automotive painting industry. The geometric complexity of automotive surfaces and the complexity of the spray patterns produced by modern paint atomizers combine to make this a challenging and interesting problem. This paper documents our efforts to develop computationally tractable analytic deposition models for electrostatic rotating bell (ESRB) atomizers, which have recently become widely used in the automotive painting industry. The models presented in this paper account for both the effects of surface curvature as well as the deposition pattern of ESRB atomizers in a computationally tractable form, enabling the development of automated trajectory generation tools. We present experimental results used to develop and validate the models, and verify the interaction between the deposition pattern, the atomizer trajectory, and the surface curvature. Limitations of the deposition model with respect to predictions of paint deposition on highly curved surfaces are discussed. Note to Practitioners-The empirical paint deposition models developed herein, which are fit to experimental data, offer a significant improvement over models that are typically used in industrial robot simulations. The improved simulation results come without the computational cost and complexity of finite element methods. The models could be incorporated, as is, into existing industrial simulation tools, provided the users are cognizant of the model limitations with respect to highly curved surfaces. Although the models are based on readily available information, incorporating the models into existing robot simulation software would likely require support from the software vendor.