Behavior analysis in intellectual and developmental disabilities.

Individuals with intellectual and developmental disabilities (IDD) have deficits in adaptive behavior, slow rates of learning, and behavior disorders that interfere with learning or place them or others at risk. Since the 1960s, researchers and clinicians in the field of applied behavior analysis have used methods based on principles of learning to increase adaptive behavior and decrease the occurrence of behavior disorders of individuals with IDD. This article provides an overview of assessment and treatment strategies used in behavior analysis to effect positive changes in the quality of life for individuals with IDD and presents an illustrative case study. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila

The specification of the R7 photoreceptor cell fate in the developing eye of Drosophila depends on the local activation of the sevenless (sev) receptor tyrosine kinase by boss, a protein expressed on the membrane of the neighboring R8 cell. Constitutive activation of the sev receptor results in a dosage dependent increase in the number of R7 cells per ommatidium. Genetic screens have been used to identify mutations that alter the efficiency of signal transduction. Subsequent molecular characterization of the corresponding genes has led to the identification of a number of proteins involved in transducing the signal from the receptor to the nucleus. In contrast to the receptor and its ligand, these components are shared between different signal transduction pathways not only in Drosophila but are also homologous to components involved in signal transduction in other organisms.     

More problems and less support: Early adolescent adjustment forecasts changes in perceived support from parents.

This study examines longitudinal associations between adolescent adjustment and perceived parental support across the middle-school years (ages 11 to 13) in a diverse sample of 197 girls and 116 boys. Growth curve models revealed associations between the slope of change in perceptions of support in relationships with mothers and fathers and the slope of change in adolescent internalizing and externalizing symptoms such that declining support accompanied increasing problems. After controlling for this correlated change, there was still evidence of child-problem effects on changes in relationship support (i.e., initial levels of adolescent externalizing symptoms predicted subsequent changes in perceived parental support), but there was no evidence of parent-support effects on changes in adjustment (i.e., initial levels of relationship support did not predict changes in adolescent externalizing symptoms). Declines in perceived parental support were steeper at high-initial levels of adolescent externalizing than at average or low levels. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

AWSum-Combining Classi cation with Knowledge Aquisition

Many classi ers achieve high levels of accuracy but have limited applicability in real world situations because they do not lead to a greater understanding or insight into the way features in uence the classi cation. In areas such as health informatics a classi er that clearly identi es the in uences on classi cation can be used to direct research and formulate interventions. This research investigates the practical applications of Automated Weighted Sum, (AWSum), a classi er that provides accuracy comparable to other techniques whist providing insight into the data. This is achieved by calculating a weight for each feature value that represents its in uence on the class value. The merits of this approach in classi cation and insight are evaluated on a Cystic Fibrosis and Diabetes datasets with positive results.     

Thymus Extracellular Matrix-Derived Scaffolds Support Graft-Resident Thymopoiesis and Long-Term In Vitro Culture of Adult Thymic Epithelial Cells

The thymus provides the physiological microenvironment critical for the development of T lymphocytes, the cells that orchestrate the adaptive immune system to generate an antigen-specific response. A diverse population of stroma cells provides surface-bound and soluble molecules that orchestrate the intrathymic maturation and selection of developing T cells. Forming an intricate 3D architecture, thymic epithelial cells (TEC) represent the most abundant and important constituent of the thymic stroma. Effective models for in and ex vivo use of adult TEC are still wanting, limiting the engineering of functional thymic organoids and the understanding of the development of a competent immune system. Here a 3D scaffold is developed based on decellularized thymic tissue capable of supporting in vitro and in vivo thymopoiesis by both fetal and adult TEC. For the first time, direct evidences of feasibility for sustained graft-resident T-cell development using adult TEC as input are provided. Moreover, the scaffold supports prolonged in vitro culture of adult TEC, with a retained expression of the master regulator Foxn1. The success of engineering a thymic scaffold that sustains adult TEC function provides unprecedented opportunities to investigate thymus development and physiology and to design and implement novel strategies for thymus replacement therapies.     

Common and distinct roles of DFos and DJun during Drosophila development

The Drosophila homolog of c-Jun regulates epithelial cell shape changes during the process of dorsal closure in mid-embryogenesis. Here, mutations in the DFos gene are described. In dorsal closure, DFos cooperates with DJun by regulating the expression of dpp; Dpp acts as a relay signal that triggers cell shape changes and DFos expression in neighboring cells. In addition to the joint requirement of DFos and DJun during dorsal closure, DFos functions independently of DJun during early stages of embryogenesis. These findings demonstrate common and distinct roles of DFos and DJun during embryogenesis and suggest a conserved link between AP-1 (activating protein-1) and TGF-beta (transforming growth factor-beta) signaling during epithelial cell shape changes.     

Speech information retrieval: a review

Speech is an information-rich component of multimedia. Information can be extracted from a speech signal in a number of different ways, and thus there are several well-established speech signal analysis research fields. These fields include speech recognition, speaker recognition, event detection, and fingerprinting. The information that can be extracted from tools and methods developed in these fields can greatly enhance multimedia systems. In this paper, we present the current state of research in each of the major speech analysis fields. The goal is to introduce enough background for someone new in the field to quickly gain high-level understanding and to provide direction for further study.     

A Visual Analytics Approach to Understanding Spatiotemporal Hotspots

As data sources become larger and more complex, the ability to effectively explore and analyze patterns among varying sources becomes a critical bottleneck in analytic reasoning. Incoming data contain multiple variables, high signal-to-noise ratio, and a degree of uncertainty, all of which hinder exploration, hypothesis generation/exploration, and decision making. To facilitate the exploration of such data, advanced tool sets are needed that allow the user to interact with their data in a visual environment that provides direct analytic capability for finding data aberrations or hotspots. In this paper, we present a suite of tools designed to facilitate the exploration of spatiotemporal data sets. Our system allows users to search for hotspots in both space and time, combining linked views and interactive filtering to provide users with contextual information about their data and allow the user to develop and explore their hypotheses. Statistical data models and alert detection algorithms are provided to help draw user attention to critical areas. Demographic filtering can then be further applied as hypotheses generated become fine tuned. This paper demonstrates the use of such tools on multiple geospatiotemporal data sets.     

Hedgehog directly controls initiation and propagation of retinal differentiation in the Drosophila eye

Patterning of the compound eye begins at the posterior edge of the eye imaginal disc and progresses anteriorly toward the disc margin. The advancing front of ommatidial differentiation is marked by the morphogenetic furrow (MF). Here we show by clonal analysis that Hedgehog (Hh), secreted from two distinct populations of cells has two distinct functions: It was well documented that Hh expression in the differentiating photoreceptor cells drives the morphogenetic furrow. Now we show that, in addition, Hh, secreted from cells at the posterior disc margin, is absolutely required for the initiation of patterning and predisposes ommatidial precursor cells to enter ommatidial assembly later. These two functions of Hh in eye patterning are similar to the biphasic requirement for Sonic Hh in patterning of the ventral neural tube in vertebrates. We show further that Hh induces ommatidial development in the absence of its secondary signals Wingless (Wg) and Dpp and that the primary function of Dpp in MF initiation is the repression of wg, which prevents ommatidial differentiation. Our results show that the regulatory relationships between Hh, Dpp, and Wg in the eye are similar to those found in other imaginal discs such as the leg disc despite obvious differences in their modes of development.