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Haokun Shen Zitong Zhao Zengjue Zhao Yuyi Chen Linghua Zhang 《International journal of molecular sciences》2022,23(2)
Intestinal homeostasis is a dynamic balance involving the interaction between the host intestinal mucosa, immune barrier, intestinal microecology, nutrients, and metabolites. Once homeostasis is out of balance, it will increase the risk of intestinal diseases and is also closely associated with some systemic diseases. Probiotics (Escherichia coli Nissle 1917, Akkermansia muciniphila, Clostridium butyricum, lactic acid bacteria and Bifidobacterium spp.), maintaining the gut homeostasis through direct interaction with the intestine, can also exist as a specific agent to prevent, alleviate, or cure intestinal-related diseases. With genetic engineering technology advancing, probiotics can also show targeted therapeutic properties. The aims of this review are to summarize the roles of potential native and engineered probiotics in oncology, inflammatory bowel disease, and obesity, discussing the therapeutic applications of these probiotics. 相似文献
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以Ca(OH)2、Al(OH)3、CO2和表面改性剂为原料,清洁制备改性水铝钙石,采用转矩流变仪法和烘箱静态热老化法,研究了表面改性剂的种类对改性水铝钙石作为PVC热稳定剂的性能影响。结果表明,清洁制备的改性水铝钙石对PVC的热稳定性能优于传统制备方法。在研究的表面改性剂中,单硬脂酸甘油酯(GMS)对水铝钙石具有较好的改性作用。此外,研究了反应时间、晶化温度和晶化时间对改性水铝钙石的性能影响。在反应时间为1 h、晶化温度为90℃和晶化时间为19 h的优化条件下,GMS改性水铝钙石基热稳定剂能使PVC混炼10 min后的初期白度为90.63,长期动态热稳定时间达到1746 s。 相似文献
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In this study, a linear model predictive control (MPC) approach with optimal filters is proposed for handling unmeasured disturbances with arbitrary statistics. Two types of optimal filters are introduced into the framework of MPC to relax the assumption of integrated white noise model in existing approaches. The introduced filters are globally optimal for linear systems with unmeasured disturbances that have unknown statistics. This enables the proposed MPC to better handle disturbances without access to disturbance statistics. As a result, the effort required for disturbance modeling can be alleviated. The proposed MPC can achieve offset-free control in the presence of asymptotically constant unmeasured disturbances. Simulation results demonstrate that the proposed approach can provide an improved disturbance õrejection performance over conventional approaches when applied to the control of systems with unmeasured disturbances that have arbitrary statistics. 相似文献
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主要对影响锗单晶抛光后表面微粗糙度的关键因素—抛光液组分的作用进行分析。采用变量控制的实验方法,从活性剂、有机胺碱、氧化剂、硅溶胶磨料和螯合剂五个因素出发进行实验。针对粗糙度影响因素进行分析与优化,同时对抛光速率进行了分析,研究得出,抛光液组分中氧化剂浓度对CMP过程中锗衬底片表面微粗糙度及去除速率的影响最为显著。优化抛光液组分配比,在抛光速率基本满足工业要求(1.5μm/min)下,经过CMP后锗衬底表面微粗糙度可有效降到1.81 nm(10μm×10μm)。在最佳配比下,采用小粒径、低分散度(99%82.2 nm)的硅溶胶磨料配制抛光液,其抛光效果明显优于采用大粒径、高分散度的硅溶胶磨料配制的抛光液。 相似文献