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1.
Recent research suggests that implementing information systems presents considerable difficulties and that many implementations are total or partial failures. This paper argues that what both practitioners and students require are richer and more acceptable models of information systems implementation. Accordingly, case study data concerning the introduction of manufacturing resource planning (MRP II) are used to illustrate five patterns of behaviour (rites) which capture important social actions; and four components of changing psychological orientation. It is argued that appreciation of the rites and psychological developments identified here will support effective change programmes. Guidelines based on our model are provided for practitioners. 相似文献
2.
Identifying and integrating patient and caregiver perspectives for clinical practice guidelines on the screening and management of infectious microorganisms in hemodialysis units 下载免费PDF全文
Hilary M. Miller Allison Tong David J. Tunnicliffe Denise Campbell Jule Pinter Robert J. Commons Eugene Athan Jonathan C. Craig Nicole Gilroy Julianne Green Belinda Henderson Martin Howell Rhonda L. Stuart Carolyn van Eps Muh Geot Wong Janak de Zoysa Meg J. Jardine 《Hemodialysis international. International Symposium on Home Hemodialysis》2017,21(2):213-223
3.
Ivask A Suarez E Patel T Boren D Ji Z Holden P Telesca D Damoiseaux R Bradley KA Godwin H 《Environmental science & technology》2012,46(4):2398-2405
By exploiting a genome-wide collection of bacterial single-gene deletion mutants, we have studied the toxicological pathways of a 60-nm cationic (amino-functionalized) polystyrene nanomaterial (PS-NH(2)) in bacterial cells. The IC(50) of commercially available 60 nm PS-NH(2) was determined to be 158 μg/mL, the IC(5) is 108 μg/mL, and the IC(90) is 190 μg/mL for the parent E. coli strain of the gene deletion library. Over 4000 single nonessential gene deletion mutants of Escherichia coli were screened for the growth phenotype of each strain in the presence and absence of PS-NH(2). This revealed that genes clusters in the lipopolysaccharide biosynthetic pathway, outer membrane transport channels, ubiquinone biosynthetic pathways, flagellar movement, and DNA repair systems are all important to how this organism responds to cationic nanomaterials. These results, coupled with those from confirmatory assays described herein, suggest that the primary mechanisms of toxicity of the 60-nm PS-NH(2) nanomaterial in E. coli are destabilization of the outer membrane and production of reactive oxygen species. The methodology reported herein should prove generally useful for identifying pathways that are involved in how cells respond to a broad range of nanomaterials and for determining the mechanisms of cellular toxicity of different types of nanomaterials. 相似文献
4.
Matthew L. Breeze Elisa Leyva‐Guerrero Grant R. Yeaman Yelena Dudin Ryan Akel Phil Brune Fred Claussen Cecil Dharmasri Jenny Golbach Rong Guo Carl Maxwell Laura Privalle Hilary Rogers Kai Liu Guomin Shan Michele Yarnall Denise Thiede Nancy Gillikin 《Journal of the American Oil Chemists' Society》2015,92(8):1085-1092
Soybean agglutinin (SBA) protein, also known as soybean lectin, is regarded as an anti‐nutrient due to its negative effect on the ability of monogastric animals to gain weight following consumption of raw soybean seed. Historically, SBA has been measured using a time‐consuming and cumbersome hemagglutination procedure. The objective of our research was to obtain a validated methodology that is precise and accurate in the measurement of SBA while allowing minimally equipped laboratories to effectively conduct the analysis, thus our focus was on evaluating an existing commercially available ELISA, an enzyme‐linked‐lectin‐assay (ELLA), and a hybrid ELISA/ELLA. A new ELLA technique that can detect and quantify lectins was chosen and modified specifically for the quantitation of SBA in soybean seed. The proposed ELLA methodology is similar to a standard sandwich ELISA, and uses polyacrylamide‐linked N‐acetylgalactosamine (Gal–NAc–PAA) for a capture phase and the biotinylated version (Gal–NAc–PAA–Biotin) for detection. Based upon the validation data, the ELLA method can precisely and accurately determine soybean lectin levels in soybean seed. The validated ELLA method was used to quantify SBA in nine commercial soybean varieties introduced between 1972 and 2008 and demonstrated that the natural variability of SBA is subject to the effects of genotype and environment. 相似文献
5.
Hilary K. Snow 《Material Religion》2017,13(1):107-109
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No school is an island; it is a part of a continuum or a pipeline of institutions which together form an educational pipeline through which groups of students pass. To turn a body of data into useful information for knowledge-based decision-making at any level, data must be collected, organised, analysed and reflected upon. The purpose of this paper is to discuss how schools and other educational institutions can not only collect better data but learn how to transform that data so that the information held within can be effectively shared among all stakeholders. This process will help to ensure that the school and the entire education system provide a more seamless and effective educational pipeline for students, and ultimately improve the quality of education delivered in the country as a whole. 相似文献
8.
Miklas Scholz Jing Xu Hilary I Dodson 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2001,76(8):827-835
The aim of this study was to investigate the treatment efficiency of passive vertical‐flow wetland filters containing Phragmites australis and/or Typha latifolia and granular media of different adsorption capacities. A cost–benefit analysis was performed on the characteristics of constructed wetlands. Cheap gravel and sand as well as expensive granular activated carbon, charcoal and Filtralite (light expanded clay) were used as filter media. Different concentrations of lead and copper sulfate were added to polluted urban beck inflow water in order to simulate pre‐treated mine wastewater, landfill leachate or highway runoff. The relationships between growth media, microbial and plant communities as well as the reduction of lead, copper, five‐day biochemical oxygen demand (BOD) in particular, and potentially pathogenic bacteria were investigated. A breakthrough of copper within the first 9 weeks was only recorded for filters containing media with limited adsorption capacities. The breakthrough was independent of the presence of plants. However, after maturation of the biomass, which dominated the schmutzdecke and litter zone, lead and copper concentrations were reduced by 97–99% and BOD by 41–60% in all wetlands. There appears to be no additional benefit in using macrophytes and expensive adsorption media in constructed wetlands to enhance metal reduction during the set‐up period of 5 months. © 2001 Society of Chemical Industry 相似文献
9.
In Nigeria, food crop production rates rarely match the phenomenal population growth rates. Of greater concern is the fact that the very densely populated States, often with limited landmass, are among the low food crop producers. Equally, disturbing is the fact that some of the low densely populated States with extensive landmass experience low per capita food crop production. The consequence is overall low food crop production and food deficiency in Nigeria as a whole, but more serious in the high population density States. The differences may be blamed on the varying prevailing physical, social and economic environment in Nigeria. To ensure food security in the country, available arable land has to be properly managed in terms of land use and cropping patterns to boost food crop production for the teaming population. 相似文献
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