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排序方式: 共有606条查询结果,搜索用时 15 毫秒
1.
Jennie O'Loughlin Silvia Napolitano Fahad Alkhathami Cillian O'Beirne Daniel Marhöfer Megan O'Shaughnessy Prof. Orla Howe Prof. Matthias Tacke Dr. Marina Rubini 《Chembiochem : a European journal of chemical biology》2021,22(6):1093-1098
Antibiotic resistance is a growing problem for public health and associated with increasing economic costs and mortality rates. Silver and silver-related compounds have been used for centuries due to their antimicrobial properties. In this work, we show that 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene silver(I) acetate/NHC*-Ag-OAc (SBC3) is a reversible, high affinity inhibitor of E. coli thioredoxin reductase (TrxR; Ki=10.8±1.2 nM). Minimal inhibition concentration (MIC) tests with different E. coli and P. aeruginosa strains demonstrated that SBC3 can efficiently inhibit bacterial cell growth, especially in combination with established antibiotics like gentamicin. Our results show that SBC3 is a promising antibiotic drug candidate targeting bacterial TrxR. 相似文献
2.
This paper extends an analysis developed for tubular permanent-magnet machines to account for the effect of fringing associated with the finite length of the ferromagnetic armature core. The magnetic field distribution, established by using an analytical technique formulated in the cylindrical coordinate system, provides an accurate means of evaluating the effect of the fringing flux on the thrust force and the back-electromotive force. Finite-element calculations confirm the analytically derived results. In Part II of the paper, the analysis is used to predict the cogging force that results from end effects and to facilitate minimization of the force. 相似文献
3.
Test Case Generation as an AI Planning Problem 总被引:6,自引:0,他引:6
Adele E. Howe Anneliese von Mayrhauser Richard T. Mraz 《Automated Software Engineering》1997,4(1):77-106
While Artificial Intelligence techniques have been applied to a variety of software engineering applications, the area of automated software testing remains largely unexplored. Yet, test cases for certain types of systems (e.g., those with command language interfaces and transaction based systems) are similar to plans. We have exploited this similarity by constructing an automated test case generator with an AI planning system at its core. We compared the functionality and output of two systems, one based on Software Engineering techniques and the other on planning, for a real application: the StorageTek robot tape library command language. From this, we showed that AI planning is a viable technique for test case generation and that the two approaches are complementary in their capabilities. 相似文献
4.
The equilibrium shape and dihedral angles at the solid–liquid–vapor tri-junctions of two-phase alloy small particles containing
a cusp-oriented interface were modeled as a function of phase fraction, surface energy and the interfacial energy. The calculation
was applied to different combinations of surface and/or interfacial energies to demonstrate the various possible particle
shapes and dihedral angles that result for two-phase particles. The dihedral angles at the tri-junction vary with the phase
fraction, due to the coupling between the relative amounts of each phase, interfacial energy relative to the two surface energies
and the equilibrium conditions at the tri-junction. These features can be used to find the ratio of the interfacial energy
to the surface energies of two-phase particles for any state of matter. 相似文献
5.
Design optimization of radially magnetized, iron-cored, tubular permanent-magnet machines and drive systems 总被引:1,自引:0,他引:1
In this paper we deduce, from analytical field solutions, the influence of leading design parameters on the performance of a radially magnetized, iron-cored, tubular permanent-magnet machine and its drive system. We derive analytical formulas for predicting the open-circuit electromotive force, the thrust force, the iron loss, and the winding resistance and inductances, as well as the converter losses. The force density, the machine and drive system efficiencies, and the power factor and converter volt-ampere (VA) rating are established as functions of a set of machine dimensional ratios, with due account of magnetic saturation and subject to a specified thermal constraint. We validate the utility and accuracy of the analytically derived formulas by finite-element calculations. Finally, we show that the design optimization of such a linear drive system must account for the losses and VA rating of the converter as well as the design parameters of the tubular machine. 相似文献
6.
The data recovered from compact discs are contaminated with errors that exhibit a bursty behavior. A channel model is developed to characterize the error bursts and good-data gaps that occur in actual data recovered from compact discs. The probability of having m erroneous symbols in a data block of length n symbols is calculated using the channel model. This probability can be used to evaluate the performance of the error-correction code (ECC) used in the compact disc system 相似文献
7.
Characterization of a diffusion-bonded Al-Mg alloy/SiC interface by high resolution and analytical electron microscopy 总被引:6,自引:0,他引:6
The interfacial structure of a diffusion-bonded Al-4.55 at. pct Mg/SiC interface was examined by conventional and high-resolution
transmission electron microscopy. Formation of Mg2Si, MgO, and Al2MgO4 was observed. The monoclinic Mg2Si phase formed at the Al/SiC interface, while the oxides MgO and Al2MgO4 formed at the monoclinic Mg2Si/Al interface. It is shown that the formation of these phases can be predicted using simple thermodynamic criteria such
as the relative bond strengths between Al, Si, C, O, and Mg. In addition, precipitation of some equilibrium Al8Mg5 precipitate was also observed at the interface. The interfacial structure observed in the Al-Mg/SiC system is contrasted
with that observed in the pure Al/SiC system. 相似文献
8.
Selhi H. Christopoulos C. Howe A.F. Hui S.Y.R. 《Energy Conversion, IEEE Transaction on》1996,11(2):287-297
The simulation of a complete induction motor drive is presented. The entire network is modelled using the transmission-line modelling (TLM) technique. The network is split into three sections which are solved independently and are joined together by link transmission-line models. Advantages of this approach are the explicit nature of the algorithm which remains unaltered irrespective of the network topology, unconditional stability, and straightforward modelling of switching elements. Results are presented for a complete drive which illustrate the capabilities and flexibility of the simulation technique 相似文献
9.
In Situ Formation of a Novel Nanocomposite Structure Based on MCM-41 and Polyethylene 总被引:1,自引:0,他引:1
M41S materials are prepared by in situ assembly of inorganic precursors and organic template and can be viewed as nanocomposites of the siliceous phase and organic surfactant. Calcination of these precursors gives the M41S materials that have been used to prepare novel nanocomposite structures, in which the organic phase inside the nano-sized pores is isolated by the nano-sized inorganic pore walls. The nanocomposite structures can be formed by in situ polymerization of monomers inside the channels. Polymerization of ethylene takes place inside the nano-sized pores, producing the desired nanocomposite structure. The resulting polyethylene was found to be a mixture of crystalline and amorphous phases. 相似文献
10.
The experimental determination and computer simulation of the micro‐segregation accompanying the solidification of alloys continues to be a subject of much academic and industrial interest. Both are subject to progressively more sophisticated analyses, and a discussion is offered regarding the development and practical use of such studies. Simple steels are particularly difficult targets for such work: solidification does not end conveniently in a eutectic, the rapid diffusion particularly in the delta‐ferrite phase obscures most evidence of what had occurred at the micro‐scale during solidification, and one or more subsequent solid state phase transformations further obscure such details. Also, solidification at the micro‐scale is inherently variable: the usual, dendrite morphologies encountered are, after all, instabilities in growth behaviour, and therefore such variability should be expected. For questions such as the relative susceptibility of different grades to particular problems, it is the average, typical behaviour that is of interest, whereas for other questions such as the on‐set of macro‐segregation, the local variability is paramount. Depending on the question being asked, and indeed the accuracy with which validatory data are available, simple pseudo‐analytical equations employing various limiting assumptions, or sophisticated models which remove the need for most such limitations, could be appropriate. This paper highlights the contribution to such studies of various collaborative research forums with‐in the European Union with which the author is involved. 相似文献