Influence of lead on metabolism of vitamins B group in alimentary iron deficient rats

Gamma delta T-Cells represent a minor subpopulation of T-lymphocytes in man and their role in normal and diseased human skin is unknown. This article is a comprehensive review of T-lymphocytes bearing the gamma delta T-cell receptor in normal and pathological human skin. Firstly, we have documented the occurrence of gamma delta T-cells in normal skin and in a range of reactive and malignant skin conditions. We have then discussed the experimental findings regarding the repertoire used by gamma delta T-cells in normal human skin and in cutaneous disorders with an increased percentage of gamma delta T-cells.     

Mediastinal pseudotumor

A case of mediastinum vascular abnormality is presented consisting in the right side location of the aortic crutch and descending aorta. Besides an abnormality of brachiocephalic trunk issue and position is described. The possible diagnosis errors are discussed.     

Pharmacological distribution diagrams: a tool for de novo drug design

BACKGROUND: There is no empirical data available on attitudes concerning AIDS and habits towards HIV infected patients of physicians in general or private practice. In this study results of a self-evaluation are presented. METHODS: 178 physicians working with out-patients in different medical fields were randomly selected for a cross sectional study and interviewed using a standardised questionnaire. RESULTS: 89% think that they are sufficiently informed about AIDS (in the USA 20%). They regarded the risk of infection to be lower than the Anglo-American physicians. They believed there is a lack of interchange of information between colleagues regarding the degree of infectiousness of referred patients. A third of the physicians fear that other patients will go elsewhere if they find out that their physician is treating AIDS patients. 54% would hold special clinic sessions for HIV-patients outside the normal schedule for practice times. 89% believed that HIV patients were partly to blame for their illness. CONCLUSIONS: Although the physicians recognise the problem of HIV-infection, they partly deny the real necessities and facts. A reason for this could be the emotions underlying the general attitude to everything pertaining to HIV-disease. Attitudes to HIV-disease and the dealing with it in daily practice must be considered on the basis of individual emotional motives.     

Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions

We investigated clinical efficacy of green tea extracts (polyphenon E; poly E and (-)-epigallocatechin-3-gallate [EGCG]) delivered in a form of ointment or capsule in patients with human papilloma virus (HPV) infected cervical lesions. Fifty-one patients with cervical lesions (chronic cervicitis, mild dysplasia, moderate dysplasia and severe dysplasia) were divided into four groups, as compared with 39 untreated patients as a control. Poly E ointment was applied locally to 27 patients twice a week. For oral delivery, a 200 mg of poly E or EGCG capsule was taken orally every day for eight to 12 weeks. In the study, 20 out of 27 patients (74%) under poly E ointment therapy showed a response. Six out of eight patients under poly E ointment plus poly E capsule therapy (75%) showed a response, and three out of six patients (50%) under poly E capsule therapy showed a response. Six out of 10 patients (60%) under EGCG capsule therapy showed a response. Overall, a 69% response rate (35/51) was noted for treatment with green tea extracts, as compared with a 10% response rate (4/39) in untreated controls (P<0.05). Thus, the data collected here demonstrated that green tea extracts in a form of ointment and capsule are effective for treating cervical lesions, suggesting that green tea extracts can be a potential therapy regimen for patients with HPV infected cervical lesions.     

Fluctuation conductivity in Li-doped YBa2Cu3O7−x

The paraconductivity of Li-doped YBa₂Cu₃O_7?x was measured. We have found that the character of the fluctuation changes as lithium content increases: instead of a crossover from 2D to 3D behavior (D is the dimensionality), as we have observed for a low doping level, a double crossover to the 2D percolative and 3D percolative regimes becomes manifest by increasing the lithium content.     

Artefacts due to static electricity in a dental school

The diagnostic usefulness of radiographs is diminished by errors of film handling, and retakes mean increased radiation doses. Avoiding artefacts due to static electricity is part of a quality assurance programme. The number of types of artefacts originating from static electricity in the Department of Radiology, School of Dentistry, Copenhagen, were recorded over a five-week period with low temperatures and low air humidity. During the period 3137 intra-oral and 638 extra-oral films were processed by seven assistants and a number of trainees. A total of 48 artefacts on 47 extra-oral films was observed. The artefacts were classified into four types. Only one case of classical 'lightning' was found, while nine were of a hitherto undescribed type ('animals' or 'cactus flowers'). The most common type appeared as dots arranged in straight lines; their origin was obscure, but it was suspected that they were caused by the processing machine. The one typical 'lightning' case occurred on a Status-X film, consistent with the theory that friction may be a causative factor. Although individual frequencies varied, all the radiography assistants and trainees were associated with the artefacts recorded.     

Outcome of rheumatoid arthritis and psoriasis following autologous stem cell transplantation for hematologic malignancy

Based on successful results in animal models, it has been proposed that high-dose myeloablative therapy followed by autologous bone marrow or stem cell transplantation (ABMT/ASCT) may cure autoimmune disease. The coexistence of autoimmune disease and hematologic malignancy provides an opportunity to examine the response of autoimmune disease to ABMT or ASCT. We describe 4 patients with autoimmune disease (3 with psoriasis and 1 with rheumatoid arthritis) and hematologic malignancy. In each patient, the autoimmune disease remitted posttransplantation, but, in 4 patients with long-term followup, it recurred at 8-24 months. The earliest relapse occurred in a patient treated with interferon-alpha. Our experience suggests that a single autograft with unpurged stem cells is unlikely to cure autoimmune disease, but that other strategies building on this approach are worthy of investigation.     

On the dissipation process in Bi2Sr2Ca2Cu3O10 tapes and bulk samples with preferential grain orientation in zero external magnetic field

Current-voltage characteristics of Bi₂Sr₂Ca₂Cu₃O₁₀ tapes and bulk samples with preferentially oriented crystallites have been measured in zero applied magnetic field and for temperatures close to the mean-field critical-temperature,T _c0. It was shown that the power-law dependence,V=AI ^a, valid for two-dimensional systems, does not correctly describe the data, which clearly indicate the existence of a finite critical-current density,J _c. The experimentalI-V curves are fitted quite well with the model which attributes the finite critical-current density to the coupling between the CuO₂ double layers. It was found thatJ _c vanishes at a temperature value belowT _c0. This behavior can result from the occurrence of vortex fluctuation-induced layer decoupling and/or from the contribution of entropy to the vortex unbinding process.