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1.
We have isolated a mutant which exhibits partial constitutivity for a -specific gene expression in α cells. The wild-type gene was cloned and demonstrated to be allelic to the STE13 gene, which encodes the dipeptidyl aminopeptidase involved in processing of the α-factor prepropheromone. Thus, the mating defect of the ste13 mutations in α cells may result both from the production of incompletely processed α-factor and from the increased expression of a -specific genes. The STE13 open reading frame of 931 amino acids contains a putative membrane-spanning segment near its amino terminus and is 31% identical to a second yeast dipeptidyl aminopeptidase (DAP2). A null mutant of STE13 has been constructed: it is viable and sporulation-proficient. The sequence has been deposited in the GenBank data library under Accession Number L21944. 相似文献
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Michael L. Bates Michael J. Warwick George Shearer David J. Harwood Ira D. Herriman Raymond J. Heitzman David H. Watson 《Journal of the science of food and agriculture》1985,36(1):31-36
The synthetic growth promoter diethylstilboestrol (DES) administered orally to pigs can be detected by radioimmunoassay (RIA) analysis of kidney, liver, faeces, bile and urine from animals fed continuously to slaughter, but not in muscle, fat or plasma. If treated animals are fed on material not containing DES for 72 h prior to slaughter, then the levels of parent compound and metabolite in all products decrease to become not significantly greater than those in control animals. The gross metabolism of DES in pigs and bovines appears to be similar. 相似文献
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Ira S. Gottfried 《Information Systems Management》2013,30(2):86-89
The importance of securing data against the threat of natural disasters i s something most MIS managers don't realize until it's too late. This column describes how two fires and an earthquake adversely affected several companies that were unprepared, or only partially prepared, for such disasters. It also discusses disaster recovery measures some MIS executives believe their companies should strengthen not only to protect the data center but to reduce their employees risk of losing valuable informa- tion from office files. 相似文献
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Frederick Ira Moxley Tim Byrnes Fumitaka Fujiwara Weizhong Dai 《Computer Physics Communications》2012,183(11):2434-2440
The Quantum Finite-Difference Time-Domain (FDTD-Q) method is a numerical method for solving the time evolution of the Schrödinger equation. It can be applied to systems of interacting particles, allowing for realistic simulations of quantum mechanics of various experimental systems. One of the drawbacks of the method is that divergences in the numerical evolution occur rather easily in the presence of interactions, which necessitates a large number of evolution steps or imaginary time evolution. We present a generalized (GFDTD-Q) method for solving the time-dependent Schrödinger equation including interactions between the particles. The new scheme provides a more relaxed condition for stability when the finite difference approximations for spatial derivatives are employed, as compared with the original FDTD-Q scheme. We demonstrate our scheme by simulating the time evolution of a two-particle interaction Hamiltonian. Our results show that the generalized method allows for stable time evolutions, in contrast to the original FDTD-Q scheme which produces a divergent solution. 相似文献
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Ira Michael Heyman 《Journal of the American Planning Association. American Planning Association》2013,79(3):247-254
Population projections for subcounty areas often are made by extrapolating past population trends. Although more sophisticated methods exist and population extrapolations long have been criticized for their weak theoretical foundations, they remain an extremely popular planning tool in part because constraints of data, time, funds, and expertise make the more sophisticated methods infeasible. The objective of this research was to document the level of accuracy of a number of commonly used extrapolative methods and, thereby, to offer suggestions for their use. For example, exponential extrapolation was found to be most accurate for rapidly growing or declining areas, whereas linear extrapolation was most accurate for moderately growing areas. More than thirty-five hundred simulated population projections for 1960 and 1970 were made for most of the methods being tested. Then the simulated projections were compared to the actual populations to measure percentage errors and tendencies to over- or underestimate. The results indicate that extrapolative methods may yield sufficiently accurate projections for many planning purposes. 相似文献
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Heil Sarah H.; Higgins Stephen T.; Mongeon Joan A.; Badger Gary J.; Bernstein Ira M. 《Canadian Metallurgical Quarterly》2006,14(2):165
Maternal smoking is a leading preventable cause of poor pregnancy outcomes and infant morbidity and mortality. Whereas pregnancy has been thought of as a "window of opportunity" when women are more motivated to change health behaviors such as smoking, only 20% of pregnant women quit smoking upon learning they are pregnant and remain abstinent at the end of the pregnancy. Greater understanding of possible obstacles to smoking during pregnancy, such as nicotine withdrawal, is needed. The symptoms of nicotine withdrawal have been well characterized in nonpregnant smokers, but there has been only 1 report conducted during pregnancy, and that was a retrospective study. The aim of the present study was to characterize nicotine withdrawal and craving in pregnant cigarette smokers. These data were collected as part of prospective clinical trials assessing the efficacy of voucher-based incentives to promote abstinence from cigarette smoking during pregnancy and postpartum. The authors examined results from the Minnesota Nicotine Withdrawal Scale (J. R. Hughes & D. K. Hatsukami, 1998) in 27 abstainers (reported no or very low levels of smoking, which was confirmed biochemically) and 21 smokers (smoked at >80% of their baseline smoking level) during the first 5 days of a cessation attempt. Abstainers reported more impatience, anger, and difficulty concentrating than did smokers. The results also suggest that pregnant smokers generally may have elevated baseline levels of withdrawal, which need to be considered in the design and analysis of future studies. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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CAD/CAM技术在脚医学中的应用 总被引:1,自引:0,他引:1
将CAD/CAM技术与脚医学结合,研究开发脚支撑设计制造系统,包括脚底曲面数据的读取及处理,根据医疗规划完成三维脚支撑模型的构造,平衡及光滑处理,激光快速原型文件和铣削加工刀具轨迹的自动生成等。 相似文献