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ABSTRACT

This article presents a multiscale modeling approach for reproducing the measurement of the wheel–rail contact area using pressure measurement film when the roughness of the mating surfaces cannot be neglected. The microscopic contact behavior between the film and test bodies was investigated with the aid of the finite element method based on scanned surface data and was later implemented in a macroscopic model that reproduced the contact area measurement procedure. The validity of the modeling technique was confirmed by the consistency between simulated results and experimental measurements. It was also demonstrated that the response of the pressure measurement film to roughness variations is consistent with the governing contact mechanics.  相似文献   
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Among the different types of stimuli‐responsive polymers, conjugated polymers reveal unique multiresponsive behavior. In this work, the synthesis and characterization of new functional poly(3,4‐ethylenedioxythiophenes) (PEDOT) bearing imidazolium ionic‐liquid moieties (PEDOT‐Im) is reported. PEDOT‐Im polymers show multiresponsive properties to a variety of stimuli, such as temperature, pH, oxidative doping, and presence of anions. These stimuli provoke different changes in PEDOT‐Im, such as changes in color, oxidation state, and, wetting behavior. In all cases, a reversible effect is observed, and the polymers reveal responsive properties in solution as well as in the form of thin films. Whereas sensitiveness to pH and oxidative doping are known phenomena for other PEDOT derivatives, responsiveness to temperature and to anions is a unique property of PEDOT‐Im. The anion exchange is further investigated by means of the Quartz Crystal Microbalance with dissipation. Anion exchanges induce fast, adjustable, and reversible contact angle changes between 24° and 107°. As a potential application, surfaces with switchable wettability triggered by anion solutions are prepared by spin‐coating PEDOT‐Im films onto different substrates.  相似文献   
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While innovations in metal forming technology are closely linked to material science, automation, and mechatronization in recent decades, nowadays, and in the upcoming years, they are supposed to be driven by digital transformation and virtualization. Motivated by this expectation and the fact that the dynamic, process-relevant thermophysical state variables in plates during rolling are difficult or even impossible to measure, a modularly structured 2D/3D model, integrated into a digital shadow, is built and validated against a metrologically accessible process data. The decisive innovation of the presented modeling strategy is the investigation of the state during longitudinal rolling in the fillet, depending on the width direction. The fillet marks the heavy plate without head and tail crops, developed during longitudinal rolling. Application of the simulation tool reveals significant temperature gradients near the plate surfaces, both horizontally and vertically, but also a region of nearly constant temperature near the core. The development of the fillet cross-section shape, including the emergence of bulges or contractions at the side surfaces, is predicted within the simulation. The digital shadow is scalable and has a parameterized structure so that rolling schedules of different compositions can be simulated.  相似文献   
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Background

Soccer is a form of exercise that induces inflammatory response, as well as an increase in free radicals potentially leading to muscle injury. Balanced nutritional intake provides important antioxidant vitamins, including vitamins A, C and E, which may assist in preventing exercise-related muscle damage. The purpose of the present study was to determine the effect of macro/micronutrient intake on markers of oxidative stress, muscle damage, inflammatory and immune response in female soccer players.

Methods

Twenty-eight female players belonging to two soccer teams of the same professional soccer club participated in this study after being informed about the aims and procedures and after delivering written consent. Each team completed an 8-day dietary record and played one competition match the same week. Participants were divided into two groups: the REC group (who complied with recommended intakes) and the NO-REC group (who were not compliant). Laboratory blood tests were carried out to determine hematological, electrolytic and hormonal variables, as well as to monitor markers of cell damage and oxidative stress. Blood samples were obtained 24 h before, immediately after and 18 h after official soccer matches. Student t-test or Mann?CWhitney U-test was used to compare both groups throughout the match.

Results

At rest, we observed that the REC group had higher levels of total antioxidant status (TAS), glutathione peroxidase (GPx), and lower levels of creatine kinase (CK) and lactate dehydrogenase (LDH) in comparison to the NO-REC group. Immediately after the match, levels of TAS, GPx, superoxide dismutase (SOD), LDH and % lymphocytes were higher and the % of neutrophils were lower in the REC group compared to the NO-REC group. These differences were also maintained 18 h post-match, only for TAS and GPx.

Conclusions

Our data reveal an association between nutritional intake and muscle damage, oxidative stress, immunity and inflammation markers. The benefit of the intake of specific nutrients may contribute to preventing the undesirable physiological effects provoked by soccer matches.  相似文献   
6.
Anatomic differences on the toe pad epithelial cells of torrent and tree frogs (elongated versus regular geometry) are believed to account for superior ability of torrent frogs to attach to surfaces in the presence of running water. Here, the friction properties of artificial hexagonal arrays of polydimethylsiloxane (PDMS) pillars (elongated and regular) in the presence of water are compared. Elongated pillar patterns show significantly higher friction in a direction perpendicular to the long axis. A low bending stiffness of the pillars and a high edge density of the pattern in the sliding direction are the key design criteria for the enhanced friction. The elongated patterns also favor orientation‐dependent friction. These findings have important implications for the development of new reversible adhesives for wet conditions.  相似文献   
7.
Protein–membrane interactions are still an important topic of investigation. One of the suitable experimental techniques used by the scientific community to address such question is atomic force microscopy. In a previous work, we have reported that the binding mechanism between the cytolytic and antimicrobial protein (Cyt2Aa2) and lipid/cholesterol bilayers was concentration‐dependent, leading to either the formation of holes in the bilayer or aggregates. Here we study such binding mechanism as a function of time at low protein concentrations (10 µg/mL). We demonstrate that although holes are formed during the first stages of the protein–lipid interaction, a reparation process due to molecular mobility in the bilayer leads to a homogenous and isotropic protein–lipid/cholesterol layer within 3 hr. The combination of imaging, force spectroscopy, and phase contrast delivered information about topography dynamics (molecular mobility), layer thickness, and mechanical properties of the protein–lipid/cholesterol system. These results highlight the importance of the observation time in (such type of) protein–lipid interactions (at low protein concentrations).  相似文献   
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Atomic force microscopy (AFM) is today an established tool in imaging and determination of mechanical properties of biomaterials. Due to their complex organization, those materials show intricate properties such as viscoelasticity. Therefore, one has to consider that the loading rate at which the sample is probed will lead to different mechanical response (properties). In this work, we studied the dependence of the mechanical properties of endothelial cells on the loading rate using AFM in force spectroscopy mode. We employed a sharp, four‐sided pyramidal indenter and loading rates ranging from 0.5 to 20 μm/s. In addition, by variation of the load (applied forces from 100 to 10,000 pN), the dependence of the cell properties on indentation depth could be determined. We then showed that the mechanical response of endothelial cells depends nonlinearly on the loading rate and follows a weak power‐law. In addition, regions of different viscous response at varying indentation depth could be determined. Based on the results we obtained, a general route map for AFM users for design of cell mechanics experiments was described.  相似文献   
10.
SOM Segmentation of gray scale images for optical recognition   总被引:3,自引:0,他引:3  
This paper describes a clustering technique using Self Organizing Maps and a two-dimensional histogram of the image. The two-dimensional histogram is found using the pixel value and the mean in the neighborhood. This histogram is fed to a self organizing map that divides the histogram into regions. Carefully selecting the number of regions, a scheme that allows an optimum optical recognition of texts can be found.

The algorithm is specially suited for optical recognition application where a very high degree of confidence is needed. As an example application, the algorithm has been tested in a voting application, where a high degree of precision is required. Furthermore, the algorithm can be extended to any other thresholding or clustering applications.  相似文献   

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