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排序方式: 共有441条查询结果,搜索用时 15 毫秒
1.
FV Elmslie M Rees MP Williamson M Kerr MJ Kjeldsen KA Pang A Sundqvist ML Friis D Chadwick A Richens A Covanis M Santos A Arzimanoglou CP Panayiotopoulos D Curtis WP Whitehouse RM Gardiner 《Canadian Metallurgical Quarterly》1997,6(8):1329-1334
The epilepsies are a group of disorders characterised by recurrent seizures caused by episodes of abnormal neuronal hyperexcitability involving the brain. Up to 60 million people are affected worldwide and genetic factors may contribute to the aetiology in up to 40% of patients. The most common human genetic epilepsies display a complex pattern of inheritance. These are categorised as idiopathic in the absence of detectable structural or metabolic abnormalities. Juvenile myoclonic epilepsy (JME) is a distinctive and common variety of familial idiopathic generalised epilepsy (IGE) with a prevalence of 0.5-1.0 per 1000 and a ratio of sibling risk to population prevalence (lambda(s)) of 42. The molecular genetic basis of these familial idiopathic epilepsies is entirely unknown, but a mutation in the gene CHRNA4, encoding the alpha4 subunit of the neuronal nicotinic acetylcholine receptor (nAChR), was recently identified in a rare Mendelian variety of idiopathic epilepsy. Chromosomal regions harbouring genes for nAChR subunits were therefore tested for linkage to the JME trait in 34 pedigrees. Significant evidence for linkage with heterogeneity was found to polymorphic loci encompassing the region in which the gene encoding the alpha7 subunit of nAChR (CHRNA7) maps on chromosome 15q14 (HLOD = 4.4 at alpha = 0.65; Z(all) = 2.94, P = 0.0005). This major locus contributes to genetic susceptibility to JME in a majority of the families studied. 相似文献
2.
Per Munk Nielsen Jesper Brask Lene Fjerbaek 《European Journal of Lipid Science and Technology》2008,110(8):692-700
It is well documented in the literature that enzymatic processing of oils and fats for biodiesel is technically feasible. However, with very few exceptions, enzyme technology is not currently used in commercial‐scale biodiesel production. This is mainly due to non‐optimized process design and a lack of available cost‐effective enzymes. The technology to re‐use enzymes has typically proven insufficient for the processes to be competitive. However, literature data documenting the productivity of enzymatic biodiesel together with the development of new immobilization technology indicates that enzyme catalysts can become cost effective compared to chemical processing. This work reviews the enzymatic processing of oils and fats into biodiesel with focus on process design and economy. 相似文献
3.
Abstract— A contrast‐enhanced wide‐angle high‐speed polarization modulator for active‐retarder 3‐D displays is proposed. By using a double liquid‐crystal‐cell structure together with a dedicated driving scheme and an external quarter‐wave retarder, a high‐performance modulator can be realized, resulting in minimized brightness loss and low cross‐talk levels in fast‐refresh time‐multiplexed 3‐D displays. 相似文献
4.
The kinetics of vinyl chloride and vinyl acetate emulsion polymerization are reexamined. The validity of Ugelstad's model for systems with high desorption rate is confirmed by simulating conversion histories for both systems at different initiator concentrations and particle numbers. On the basis of the model, it is shown that at ordinary initiation rates, termination reactions are unimportant with respect to molecular weight development in both systems, and as a consequence, molecular weight development is independent of number and size distribution of polymer particles and of initiator and emulsifier level. Based on this conclusion, it is shown that in accordance with experimental facts, the molecular weight distribution obtained in vinyl chloride emulsion polymerization is the most probable distribution, and it is concluded that the number of long-chain branch points per repetition unit is less than 2 × 10?4 at high conversions. In vinyl acetate emulsion polymerization, an almost logarithmic normal distribution is obtained. The distribution is strongly broadened by branching reactions with the number of long-chain branch points increasing rapidly with monomer conversion. The increase of Mn with increasing conversion is due to terminal double-bond polymerization, while the increase in Mw is due mainly to transfer to polymer. 相似文献
5.
Mortensen Jesper Yu Insu Khanna Pankaj Tecchia Franco Spanlang Bernhard Marino Giuseppe Slater Mel 《Computer Graphics and Applications, IEEE》2008,28(6):56-64
Real-time global illumination in VR systems enhances scene realism by incorporating soft shadows, reflections of objects in the scene, and color bleeding. The Virtual Light Field (VLF) method enables real-time global illumination rendering in VR. The VLF has been integrated with the Extreme VR system for real-time GPU-based rendering in a Cave Automatic Virtual Environment. 相似文献
6.
Ivan Damgård Mads Jurik Jesper Buus Nielsen 《International Journal of Information Security》2010,9(6):371-385
We propose a generalization of Paillier’s probabilistic public-key system, in which the expansion factor is reduced and which
allows to adjust the block length of the scheme even after the public key has been fixed, without losing the homomorphic property.
We show that the generalization is as secure as Paillier’s original system and propose several ways to optimize implementations
of both the generalized and the original scheme. We construct a threshold variant of the generalized scheme as well as zero-knowledge
protocols to show that a given ciphertext encrypts one of a set of given plaintexts, and protocols to verify multiplicative
relations on plaintexts. We then show how these building blocks can be used for applying the scheme to efficient electronic
voting. This reduces dramatically the work needed to compute the final result of an election, compared to the previously best
known schemes. We show how the basic scheme for a yes/no vote can be easily adapted to casting a vote for up to t out of L candidates. The same basic building blocks can also be adapted to provide receipt-free elections, under appropriate physical
assumptions. The scheme for 1 out of L elections can be optimized such that for a certain range of the other parameter values, the ballot size is logarithmic in
L. 相似文献
7.
Anders Bruun Dimitrios Raptis Jesper Kjeldskov Mikael B. Skov 《Behaviour & Information Technology》2016,35(3):233-249
Coolness has recently started to be explored as a design goal for interactive products from practitioners as well as researchers within human–computer interaction (HCI), but there is still a need to further operationalise the concept and explore how we can measure it. Our contribution in this paper is the COOL questionnaire. We based the creation of the questionnaire on literature suggesting that perceived coolness is decomposed to outer cool (the style of a product) and inner cool (the personality characteristics assigned to it). In this paper, we focused on inner cool, and we identified 11 inner cool characteristics. These were used to create an initial pool of question items and 2236 participants were asked to assess 16 mobile devices. By performing exploratory and confirmatory factor analyses, we identified three factors that can measure the perceived inner coolness of interactive products: desirability, rebelliousness and usability. These factors and their underlying 16 question items comprise the COOL questionnaire. The whole process of creating the questionnaire is presented in detail in this paper and we conclude by discussing our work against related work on coolness and HCI. 相似文献
8.
In this paper we apply the direct non-equilibrium molecular dynamics technique to oscillatory flows of fluids in microscopic channels. Initially, we show that the microscopic simulations resemble the macroscopic predictions based on the Navier–Stokes equation very well for large channel width, high density and low temperature. Further simulations for high temperature and low density show that the non-slip boundary condition traditionally used in the macroscopic equation is greatly compromised when the fluid–wall interactions are the same as the fluid–fluid interactions. Simulations of a system with very narrow channel width confirm earlier findings of Poiseuille flow, namely, that the velocity profiles are modulated. We find that these modulations cannot be explained by the local area density model.
相似文献
Jesper S. HansenEmail: |
9.
Shreesha Rao D.S Mikkel Jensen Lars Grüner-Nielsen Jesper Toft Olsen Peter Heiduschka Bj?rn Kemper Jürgen Schnekenburger Martin Glud Mette Mogensen Niels M?ller Israelsen Ole Bang 《光:科学与应用(英文版)》2021,10(7):1372-1384
We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography (SD-OCT) with an axial resolution of ... 相似文献
10.
Mikael B. Skov Jesper Kjeldskov Jeni Paay Niels Husted Jacob Nørskov Kenneth Pedersen 《Pervasive and Mobile Computing》2013,9(2):216-227
Some movements within modern architecture particularly emphasise the importance of matching buildings to their surroundings. However, practicing such “contextual architecture” is highly challenging and typically not something the future inhabitants of a building are well equipped for participating in. This paper explores the potentials of using mobile phone technology for facilitating such client participation in the parts of an architecture process that take place on the building site. For this we introduce ArchiLens, a mobile system for interactive on-site 3D visualisation of houses, and findings from a field study with 40 participants in the process of building or modifying their home. The study showed that using the system helped evoke people’s imagination of the look and feel of their future house, and envision it in context. This enabled them to participate more closely in the design process on-site by iteratively reviewing design alternatives and exploring, for example, other placements and materials. 相似文献