全文获取类型
收费全文 | 2462篇 |
免费 | 6篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 3篇 |
综合类 | 2篇 |
化学工业 | 27篇 |
金属工艺 | 10篇 |
机械仪表 | 9篇 |
建筑科学 | 8篇 |
能源动力 | 5篇 |
轻工业 | 73篇 |
水利工程 | 1篇 |
石油天然气 | 1篇 |
无线电 | 11篇 |
一般工业技术 | 16篇 |
冶金工业 | 2274篇 |
原子能技术 | 2篇 |
自动化技术 | 27篇 |
出版年
2021年 | 6篇 |
2020年 | 2篇 |
2019年 | 6篇 |
2018年 | 9篇 |
2017年 | 7篇 |
2016年 | 3篇 |
2014年 | 11篇 |
2013年 | 20篇 |
2012年 | 11篇 |
2011年 | 10篇 |
2010年 | 10篇 |
2009年 | 11篇 |
2008年 | 5篇 |
2007年 | 9篇 |
2006年 | 7篇 |
2005年 | 4篇 |
2004年 | 8篇 |
2003年 | 8篇 |
2002年 | 11篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 76篇 |
1998年 | 759篇 |
1997年 | 429篇 |
1996年 | 240篇 |
1995年 | 140篇 |
1994年 | 119篇 |
1993年 | 143篇 |
1992年 | 14篇 |
1991年 | 22篇 |
1990年 | 28篇 |
1989年 | 27篇 |
1988年 | 33篇 |
1987年 | 34篇 |
1986年 | 20篇 |
1985年 | 25篇 |
1984年 | 2篇 |
1983年 | 7篇 |
1982年 | 11篇 |
1981年 | 8篇 |
1980年 | 19篇 |
1978年 | 4篇 |
1977年 | 46篇 |
1976年 | 91篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1970年 | 2篇 |
1969年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有2469条查询结果,搜索用时 31 毫秒
1.
Sarah Gilgunn Keefe Murphy Henning Stckmann Paul J. Conroy T. Brendan Murphy R. William Watson Richard J. OKennedy Pauline M. Rudd Radka Saldova 《International journal of molecular sciences》2020,21(23)
The diagnosis and treatment of prostate cancer (PCa) is a major health-care concern worldwide. This cancer can manifest itself in many distinct forms and the transition from clinically indolent PCa to the more invasive aggressive form remains poorly understood. It is now universally accepted that glycan expression patterns change with the cellular modifications that accompany the onset of tumorigenesis. The aim of this study was to investigate if differential glycosylation patterns could distinguish between indolent, significant, and aggressive PCa. Whole serum N-glycan profiling was carried out on 117 prostate cancer patients’ serum using our automated, high-throughput analysis platform for glycan-profiling which utilizes ultra-performance liquid chromatography (UPLC) to obtain high resolution separation of N-linked glycans released from the serum glycoproteins. We observed increases in hybrid, oligomannose, and biantennary digalactosylated monosialylated glycans (M5A1G1S1, M8, and A2G2S1), bisecting glycans (A2B, A2(6)BG1) and monoantennary glycans (A1), and decreases in triantennary trigalactosylated trisialylated glycans with and without core fucose (A3G3S3 and FA3G3S3) with PCa progression from indolent through significant and aggressive disease. These changes give us an insight into the disease pathogenesis and identify potential biomarkers for monitoring the PCa progression, however these need further confirmation studies. 相似文献
2.
3.
MB Heyman JM LaBerge KA Somberg P Rosenthal C Mudge EJ Ring JD Snyder 《Canadian Metallurgical Quarterly》1997,131(6):914-919
The transjugular intrahepatic portosystemic shunt procedure is an accepted treatment for adults with complications of portal hypertension. We performed a retrospective review of all pediatric TIPS placements performed at the University of California, San Francisco between 1990 and 1996. Twelve procedures were attempted in nine children, with a mean age (+/- SD) of 9.4 +/- 3.9 years (range, 5 to 15 years) and a mean weight of 31 +/- 18 kg (range, 16 to 70 kg). The indications for TIPS placement were portal hypertension complicated by chronic variceal hemorrhage not controlled with sclerotherapy (n = 7) and hypersplenism with thrombocytopenia (n = 2). TIPS placement was successfully completed initially in seven of nine (78%) patients. Unfavorable vascular anatomy was the cause of failure in two cases. The seven patients who underwent successful TIPS placement were followed up for an average of 136 days (range, 1 to 800 days); two still have patent shunts, three underwent liver transplantation, one had a splenorenal shunt after stenosis, and one died of underlying liver disease. Variceal bleeding was controlled in four of five patients who successfully underwent TIPS placement. Shunt occlusion occurred in four patients; patency was restored by transjugular shunt revision in three, and a splenorenal shunt was performed in one. 相似文献
4.
JM Piepmeier DL Keefe MA Weinstein D Yoshida J Zielinski TT Lin Z Chen F Naftolin 《Canadian Metallurgical Quarterly》1993,32(3):422-30; discussion 430-1
Estramustine is an estradiol-based agent that has been shown to accumulate in human glioma cells, resulting in a concentration-dependent alteration in cell size and shape within minutes and an inhibition of proliferation over 3 to 6 days. We evaluated human glioblastoma cultures with [3H]thymidine incorporation assays to determine estramustine's early effects on deoxyribonucleic acid synthesis in these tumors. Because estramustine shares a common structural motif with other antimicrotubule drugs, we synthesized four A-ring conjugates of estrone that contained a carbamate moiety but lacked nitrogen mustard. These analogs were examined by [3H]thymidine incorporation and compared with vinblastine. Greater than 70% inhibition of [3H]thymidine incorporation occurred within 1 hour of treatment with estramustine at 10(-5) mol/L, which increased to 80% inhibition at 4 hours. Ethyl carbamate JE208 was nearly as effective as estramustine in inhibiting deoxyribonucleic acid synthesis, and both were more effective than vinblastine. The inhibitory effects of estramustine and estrone analogs were reversible; vinblastine was not reversible. Although estramustine and JE208 induced similar antiproliferative and morphological changes in glioblastoma cells that persisted for at least 4 days, there was a modest recovery of morphology and thymidine incorporation with JE208 after prolonged treatment. The common findings with estramustine and JE208 suggest that these agents may have a similar mechanism of action and form the basis for the investigation of new agents that may rapidly and reversibly inhibit glioblastoma. 相似文献
5.
Gastric bacteria from cheetahs with gastritis were used to inoculate specific-pathogen free kittens and conventional mice. Helicobacter sp. and Gastrospirillum sp. colonized kittens, while only Gastrospirillum sp. colonized mice. In kittens, both bacterial species induced mild lymphofolliclar gastritis which did not change over the course of the 11 months observation period. In mice, Gastrospirillum sp. induced lymphoplasmacytic and follicular gastritis which increased in severity over 6 months and persisted for the 12 month observation period. Gastric ulcers and gastric mucosal hypertrophy were present in chronically infected mice. These results indicate that host but not bacterial factors influence the severity of gastritis, and that in mice, bacterial gastritis increases in severity with time and may lead to gastric ulceration in some individuals. 相似文献
6.
7.
8.
Evaluating and monitoring nucleation and growth in copper foil 总被引:1,自引:0,他引:1
Ye-Kun Lee Thomas J. O’Keefe 《JOM Journal of the Minerals, Metals and Materials Society》2002,54(4):37-41
The electrodeposition of copper foil for use in electronic materials applications is a complex and demanding process. The
specific aspects of producing and controlling the structure-property-performance requirements of the foil are important because
of the stringent demands placed on their use in printed circuit boards and similar products. In this paper, a brief review
of the electrodeposition process for raw copper foil is presented. Since electrolyte additives play such a significant role
in the copper-depositionprocess, the effects of two essential additives, chloride ion and an organic (e.g., glue or gelatine),
on the foil are described. Also, the influence of other operating parameters on the initial nucleation, growth, and subsequent
electrocrystallization are discussed. Selected characterization methods, such as polarization and scanning electron micrography
techniques, are described as a means of monitoring the process, but universally accepted methods of evaluating and controlling
the additives and foil quality during electrolysis are still being sought. 相似文献
9.
10.
KA Roberto 《Canadian Metallurgical Quarterly》1997,52(3):127-131
We investigated the effect of chlorpromazine (CPZ) in a murine model of T-cell-dependent liver injury caused by concanavalin A (ConA). CPZ (3 and 10 mg/kg) treatment 1 h before ConA injection prevented liver injury. CPZ (3, 10 mg/kg) administered 1 h after a ConA injection was also hepatoprotective, whereas cyclosporin (CsA, 100 mg/kg) was active only when given before ConA. Under either condition, CsA but not CPZ prevented concurrent increases in splenic ornithine decarboxylase (ODC) activity, a putative index of T-cell proliferation/differentiation. CPZ down-regulated tumor necrosis factor-alpha (TNF-alpha) and up-regulated IL-10 in mice that then received ConA, whereas delayed administration of CPZ had no effect. These results suggest that CPZ prevented liver injury without affecting the proliferation/differentiation of T-cells. The dissociation of hepatoprotection by CPZ from cytokine modulation indicates that this drug intervenes in the adherence of T-cells or the death of hepatocytes in the ConA-model. 相似文献