Moral reasoning and moral concerns: An alternative to Gilligan's gender based hypothesis.

Studied the differences in moral orientation in terms of gender specific modes of reasoning, in 2 experiments. In Exp 1, 32 Ss (aged 24–55 yrs) were read the "Heinz dilemma," and asked 3 questions regarding it. Deliberative and justificatory strategies were identified on the basis of the presence or absence of the higher level knowledge structures. In Exp 2, 40 undergraduates were presented with "Michael and Kohlberg Heinz dilemma," followed by a set of relevant questions. Male Ss preferred to apply a norm or rule in their solutions, while females rejected the application of a norm and sought alternative solutions. This was replicated in Exp 2, but the pattern was reversed with female Ss preferring to apply a norm. Males were divided in their use of either strategy indicating that although, genders differed in their judgments as to which norms or rules to apply; once adopted, norms and rules were used in similar ways. (French abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Aircraft based soil moisture retrievals under mixed vegetation and topographic conditions

An unresolved issue in global soil moisture retrieval using passive microwave sensors is the spatial integration of heterogeneous landscape features to the nominal 50 km footprint observed by most low frequency satellite systems. One of the objectives of the Soil Moisture Experiments 2004 (SMEX04) was to address some aspects of this problem, specifically variability introduced by vegetation, topography and convective precipitation. Other goals included supporting the development of soil moisture data sets that would contribute to understanding the role of the land surface in the concurrent North American Monsoon System. SMEX04 was conducted over two regions: Arizona — semi-arid climate with sparse vegetation and moderate topography, and Sonora (Mexico) — moderate vegetation with strong topographic gradients. The Polarimetric Scanning Radiometer (PSR/CX) was flown on a Naval Research Lab P-3B aircraft as part of SMEX04 (10 dates of coverage over Arizona and 11 over Sonora). Radio Frequency Interference (RFI) was observed in both PSR and satellite-based (AMSR-E) observations at 6.92 GHz over Arizona, but no detectable RFI was observed over the Sonora domain. The PSR estimated soil moisture was in agreement with the ground-based estimates of soil moisture over both domains. The estimated error over the Sonora domain (SEE = 0.021 cm³/cm³) was higher than over the Arizona domain (SEE = 0.014 cm³/cm³). These results show the possibility of estimating soil moisture in areas of moderate and heterogeneous vegetation and high topographic variability.     

Toward a brief multidimensional assessment of emotional intelligence: Psychometric properties of the Emotional Quotient Inventory—Short Form.

Although several brief instruments are available for the emotional intelligence (EI) construct, their conceptual coverage tends to be quite limited. One notable exception is the short form of the Emotional Quotient Inventory (EQ-i:S), which measures multiple EI dimensions in addition to a global EI index. Despite the unique advantage offered by the inventory, psychometric properties of the EQ-i:S scores have not yet been systematically evaluated. Such an evaluation was the main goal of the present investigation. Using data from 2,508 undergraduates, the authors conducted 2 studies involving factor structure, internal reliability, 6-month temporal stability, and construct validity of the EQ-i:S responses, both for the total EQ scale and for each constituent dimension. The results supported the multidimensional measurement structure of the EQ-i:S, with each dimension producing internally consistent, temporally stable, and theoretically meaningful responses. Scores on the EQ-i:S were associated more strongly with performance on an ability test of EI and with a conceptually similar construct of alexithymia than with the broader dimensions of basic personality and explained nontrivial amounts of incremental variance in the criterion symptoms of attention deficit/hyperactivity disorder. Moreover, scores on each EQ-i:S dimension exhibited unique patterns of associations with the validation variables. The discussion highlights the advantages of the multidimensional approach in the assessment and study of EI. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Instability of Thallium-Containing Superconductor Phases in Isothermal Equilibrium with Thallium Oxide

Knowledge of the equilibrium conditions under which the superconducting phases in the Tl-Ca-Ba-Cu-O system are stable would enable the controlled preparation of these materials. Isothermal equilibrium between samples in this quaternary system and Tl₂O vapor from a condensed thallium oxide source has been studied. None of the superconductor phases coexisted in equilibrium with thallium oxide under the conditions employed. Instead, two previously unknown ternary thallium-calcium-barium oxides and one previously unknown thallium-calcium oxide were observed. The equilibrium phase assemblage at temperatures between 825° and 925°C consisted of the most thallium-rich ternary oxide plus CuO, although small amounts of the other thallium-rich phases may be required to balance stoichiometry. The vapor pressure of Tl₂O established by pure, condensed thallium oxide clearly exceeds the stability limit for the superconductor phases. If the thallium-containing superconductors are stable phases at high temperature, they will exist over some range of lower Tl₂O partial pressure.     

Negative regulation of Wee1 expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis

The G2 cell cycle checkpoint protects cells from potentially lethal mitotic entry after DNA damage. This checkpoint involves inhibitory phosphorylation of Cdc2 at the tyrosine-15 (Y15) position, mediated in part by the Wee1 protein kinase. Recent evidence suggests that p53 may accelerate mitotic entry after DNA damage and that the override of the G2 checkpoint may play a role in the induction of apoptosis by p53. To determine the biochemical mechanism by which p53 inactivates the G2 checkpoint, the effects of p53 activation on Wee1 expression, Cdc2-Y15 phosphorylation, and cyclin B1-associated Cdc2 kinase activity were examined. Under conditions of either growth arrest or apoptosis, p53 activation resulted in the down-regulation of Wee1 expression and dephosphorylation of Cdc2. A parallel increase in cyclin B1/Cdc2 kinase activity was observed during p53-mediated apoptosis. Negative regulation of the Wee1 expression and Cdc2 phosphorylation by p53 was also evident in thymus tissue from p53+/+ mice but not from p53-/- mice. Inactivation of the G2 checkpoint may contribute to the tumor suppressor activity of p53.     

Itraconazole maintenance treatment for histoplasmosis in AIDS: a prospective, multicenter trial

The expression of cytokeratins (CKs) in normal cervical epithelium, low grade squamous intraepithelial lesions (SIL), high grade SILs and squamous cell carcinoma (SCC) were analyzed using four different monoclonal antikeratin antibodies. In normal cervical epithelium, CK 18 showed strong immunoreactivity in basal and parabasal layers. CK 19 and 14 were expressed only in the basal layer while CK 13 was found selectively n the spinal cells. As the lesions progressed from low grade SIL to high grade SIL, immunoreactivity of CK 18, 19 and 14 in the basal cell compartment increased while the expression of CK 13 decreased. In SCC, as well-differentiated tumors showed decreased immunoreactivity for CK 18, 19 and 14 with CK 13 showing a strong and focal (localized) immunoreactivity. Undifferentiated carcinomas totally lacked CK 13 reactivity. Our findings therefore suggest that expression of CK 18, 19 and 14 may be directly related to tumor grade and CK 13 may be a marker of differentiation in cervical lesions.     

Preventing discrimination against volunteers in prophylactic HIV vaccine trials: lessons from a phase II trial

OBJECTIVE: This was a randomized, double-blind, crossover study of 30 children with attention-deficit/hyperactivity disorder (ADHD) that evaluated the time course effects of four doses of Adderall (5, 10, 15, and 20 mg), an inactive control (placebo), and a positive control (clinical dose of methylphenidate). METHOD: For each treatment condition, a capsule was administered in the morning and assessments were performed in an analog classroom setting every 1.5 hours across the day. Subjective (teacher ratings of deportment and attention) and objective (scores on math tests) measures were obtained for each classroom session, and these measures were used to evaluate time-response and dose response effects of Adderall. RESULTS: For doses of Adderall greater than 5 mg, significant time course effects were observed. Rapid improvements on teacher ratings and math performance were observed by 1.5 hours after administration, and these effects dissipated by the end of the day. The specific pattern of time course effects depended on dose: the time of peak effects and the duration of action increased with dose of Adderall. CONCLUSIONS: This documentation of efficacy in a controlled study supports the addition of Adderall to the armamentarium of psychotropic medications for the treatment of ADHD. The differences in time-response patterns of Adderall and methylphenidate may help tailor treatment to meet specific clinical needs of different children with ADHD.     

Variable time delay of microwave signals using high dispersion fibre

A programmable time delay of 0-5 ns has been demonstrated for a 3 GHz signal using a tunable semiconductor diode laser and 1 km of a new high-dispersion singlemode fibre with negative chromatic dispersion. Because it is fibre based and uses direct detection, this system is resistant to vibration effects.<>     

Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group

We investigated the safety and immunogenicity of a candidate HIV-1 vaccine, Env 2-3 (Chiron Biocine Co.), in combination with an adjuvant emulsion, MF59, with or without an additional immune modulator, MTP-PE 78 healthy HIV-1-seronegative adults. Sixteen subjects participated in a dose escalation study of MTP-PE in MF59 without Env 2-3, given at 0 and 1 months; 48 subjects participated in a study of a fixed dose of 30 micrograms of Env 2-3 in MF59 with increasing doses of MTP-PE (0, 5, 10, 25, 50, and 100 micrograms), and 14 subjects participated in a study of 100 micrograms of Env 2-3 in MF59 without MTP-PE. Subjects were assigned to study groups under a randomized, double-blind allocation. Subjects received immunization at 0, 1, and 6 months, and had the option of receiving a fourth dose at 12-18 months. Env 2-3 in MTP-PE/MF59 was associated with significant reactogenicity, in that severe, although self-limited systemic and/or local reactions occurred in 15 of 30 vaccinees. In contrast, Env 2-3 in MF59 without MTP-PE was relatively well tolerated, and severe local and/or systemic reactions occurred in only 2 of 18 subjects. Env 2-3 stimulated serum antibodies to HIV-1 envelope protein (gp120) as detected by Western blot in 39 of 43 subjects and to HIV-1 virus lysate by EIA in 28 of 43 subjects after three injections. The majority of subjects also developed EIA antibodies to recombinant gp120 (SF-2), gp120 (LAI), and V3 peptide (SF-2). Neutralizing antibodies to the homologous SF-2 strain developed in 30 of 43 and 27 of 34 subjects, and fusion inhibition antibodies in 25 of 43 and 15 of 36 subjects after three and four injections, respectively. Lymphoproliferative responses to the immunogen, Env 2-3 were observed in over 80% of the vaccinees examined, and CD4+ cytotoxic T cell activity directed against HIV-1 was noted transiently in 2 of 20 vaccinees. Addition of MTP-PE to Env 2-3 or increasing the dose of Env 2-3 from 30 to 100 micrograms did not augment immunogenicity. Env 2-3 in MF59 was well tolerated and immunogenic in HIV-1-seronegative individuals. The addition of MTP-PE significantly increased reactogenicity, but had little, if any, effect on immunogenicity.