Self-discrepancy as an important factor in addressing women's emotional reactions to infertility.

Researchers have failed to establish infertility as a crisis or to identify an emotional reaction that is common to women who are faced with an inability to conceive. Many women, however, express a desire for counseling in conjunction with infertility treatment. This discrepancy in the research presents confusion for the clinician who is developing psychological interventions while working with infertile women. Infertility is approached in this article as a personal crisis that is based on a conflict between an ideal self as mother or woman and a real self as infertile. E. T. Higgins's (see record 1987-34444-001) self-discrepancy theory is proposed as a model for understanding the variability in the levels of distress and the types of emotional reactions to infertility. Clinical implications are discussed in relation to the variability of emotional reactions in female infertility clients, the selection of assessment techniques, and the selection of intervention techniques. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The polyp prevention trial I: rationale, design, recruitment, and baseline participant characteristics

The Polyp Prevention Trial (PPT) is a multicenter randomized controlled trial examining the effect of a low-fat (20% of total energy intake), high-fiber (18 g/1000 kcal), high-vegetable and -fruit (5-8 daily servings) dietary pattern on the recurrence of adenomatous polyps of the large bowel, precursors of most colorectal malignancies. Eligibility criteria include one or more adenomas removed within 6 months of randomization; complete nonsurgical polyp removal and complete colonic examination to the cecum at the qualifying colonoscopy: age 35 years of more; no history of colorectal cancer, inflammatory bowel disease, or large bowel resection; and satisfactory completion of a food frequency questionnaire and 4-day food record. Of approximately 38,277 potential participants with one or more polyps recently resected, investigators at eight clinical centers randomized 2,079 (5.4%; 1,037 in the intervention and 1,042 in the control arm) between June 1991 and January 1994, making the PPT the largest adenoma recurrence trial ever conducted. Of PPT participants, 35% are women and 10% are minorities. At study entry, participants averaged 61.4 years of age; 14% of them smoked, and 22% used aspirin. At the baseline colonoscopy, 35% of participants had two or more adenomas, and 29% had at least one large (> of = 1 cm) adenoma. Demographic, behavioral, dietary, and clinical characteristics are comparable across the two study arms. Participants have repeat colonoscopies after 1 (T(1)) and 4 (T(4)) years of follow-up. The primary end point is adenoma recurrence; secondary end points include number, size, location, and histology of adenomas. All resected lesions are reviewed centrally by gastrointestinal pathologists. The trial provides 90% power to detect a reduction of 24% in the annual adenoma recurrence rate. The primary analytic period, on which sample size calculations were based is 3 years (T(1) to T(4)), which permits a 1-year lag time for the intervention to work and allows a more definitive clearing of lesions at T(1), given that at least 10-15% of polyps may be missed at baseline. The final (T(4)) colonoscopies are expected to be completed in early 1998.