全文获取类型
收费全文 | 1511篇 |
免费 | 20篇 |
国内免费 | 3篇 |
专业分类
电工技术 | 9篇 |
综合类 | 2篇 |
化学工业 | 77篇 |
金属工艺 | 8篇 |
机械仪表 | 9篇 |
建筑科学 | 30篇 |
能源动力 | 33篇 |
轻工业 | 90篇 |
水利工程 | 7篇 |
石油天然气 | 2篇 |
无线电 | 70篇 |
一般工业技术 | 76篇 |
冶金工业 | 965篇 |
原子能技术 | 4篇 |
自动化技术 | 152篇 |
出版年
2023年 | 3篇 |
2022年 | 8篇 |
2021年 | 3篇 |
2020年 | 4篇 |
2019年 | 5篇 |
2018年 | 8篇 |
2017年 | 8篇 |
2016年 | 11篇 |
2015年 | 10篇 |
2014年 | 16篇 |
2013年 | 23篇 |
2012年 | 30篇 |
2011年 | 24篇 |
2010年 | 17篇 |
2009年 | 25篇 |
2008年 | 27篇 |
2007年 | 24篇 |
2006年 | 28篇 |
2005年 | 13篇 |
2004年 | 28篇 |
2003年 | 21篇 |
2002年 | 22篇 |
2001年 | 32篇 |
2000年 | 30篇 |
1999年 | 50篇 |
1998年 | 357篇 |
1997年 | 206篇 |
1996年 | 115篇 |
1995年 | 59篇 |
1994年 | 46篇 |
1993年 | 61篇 |
1992年 | 7篇 |
1991年 | 17篇 |
1990年 | 6篇 |
1989年 | 11篇 |
1988年 | 12篇 |
1987年 | 3篇 |
1986年 | 9篇 |
1985年 | 6篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1982年 | 6篇 |
1981年 | 9篇 |
1980年 | 9篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 35篇 |
1976年 | 69篇 |
1974年 | 2篇 |
1973年 | 2篇 |
排序方式: 共有1534条查询结果,搜索用时 9 毫秒
1.
2.
3.
In mammals, olfactory stimuli are detected by sensory neurons at two distinct sites: the olfactory epithelium (OE) of the nasal cavity and the neuroepithelium of the vomeronasal organ (VNO). While the OE can detect volatile chemicals released from numerous sources, the VNO appears to be specialized to detect pheromones that are emitted by other animals and that convey information of behavioral or physiological importance. The mechanisms underlying sensory transduction in the OE have been well studied and a number of components of the transduction cascade have been cloned. Here, we investigated sensory transduction in the VNO by asking whether VNO neurons express molecules that have been implicated in sensory transduction in the OE. Using in situ hybridization and Northern blot analyses, we found that most of the olfactory transduction components examined, including the guanine nucleotide binding protein alpha subunit (G-alpha-olf), adenylyl cyclase type III, and an olfactory cyclic nucleotide-gated (CNG) channel subunit (oCNC1), are not expressed by VNO sensory neurons. In contrast, VNO neurons do express a second olfactory CNG channel subunit (oCNC2). These results indicate that VNO sensory transduction is distinct from that in the OE but raise the possibility that, like OE sensory transduction, sensory transduction in the VNO might involve cyclic nucleotide-gated ion channels. 相似文献
4.
YV Panchin YI Arshavsky TG Deliagina GN Orlovsky LB Popova AI Selverston 《Canadian Metallurgical Quarterly》1996,109(2):361-365
The locomotor activity in the marine mollusc Clione limacina has been found to be strongly excited by serotonergic mechanisms. In the present study putative serotonergic cerebropedal neurons were recorded simultaneously with pedal locomotor motoneurons and interneurons. Stimulation of serotonergic neurons produced acceleration of the locomotor rhythm and strengthening of motoneuron discharges. These effects were accompanied by depolarization of motoneurons, while depolarization of the generator interneurons was considerably lower (if it occurred at all). Effects of serotonin application on isolated locomotor and non-locomotor pedal neurons were studied. Serotonin (5 x 10(-7) to 1 x 10(-6) M) affected most pedal neurons. All locomotor neurons were excited by serotonin. This suggests that serotonergic command neurons exert direct influence on locomotor neurons. Effects of serotonin on nonlocomotor neurons were diverse, most neurons being inhibited by serotonin. Some effects of serotonin on locomotor neurons could not be reproduced by neuron depolarization. This suggests that, along with depolarization, serotonin modulates voltage-sensitive membrane properties of the neurons. As a result, serotonin promotes the endogenous rhythmical activity in neurons of the C. limacina locomotor central pattern generator. 相似文献
5.
PB Imrey LA Jackson PH Ludwinski AC England GA Fella BC Fox LB Isdale MW Reeves JD Wenger 《Canadian Metallurgical Quarterly》1996,143(6):624-630
Between February 1991 and April 1992, eight undergraduates at a US residential university and one at a nearby 2-year college contracted serogroup C meningococcal disease. A case-control investigation with 20 controls per case, oropharyngeal carriage surveys, and multilocus enzyme electrophoresis (MEE) of serogroup C isolates were used to identify factors contributing to the outbreak. All eight sterile-site isolates from cases were closely related by MEE and were similar (though not identical) to the strain associated with the 1991-1992 epidemic of meningococcal disease in eastern Canada. Disease was associated with cigarette smoking (p = 0.012), recent patronage of campus-area bars (p = 0.034), estimated amount of time spent in campus-area bars (p = 0.0003), and, especially, recent patronage of one specific bar, bar A (p = 0.0006; odds ratio = 23.1, 95% confidence interval 3.0-571.5). In carriage surveys, 1,528 throat cultures taken from (primarily student) noncases yielded only five (0.3%) strains that were identical by MEE to those from cases. Two of these were found among 22 cultures obtained from bar A employees in spring 1992. Some cases in this outbreak may have followed transmission of the epidemic strain in bar A. Campus bar environments may facilitate the spread of meningococcal disease among teenagers and young adults. 相似文献
6.
Wayne Madsen 《Network Security》1998,1998(5):8-9
“We hear about mandatory access to encryption keys by law enforcement but nothing about privacy.” With that statement, Senator John Ashcroft of Missouri, an unannounced candidate for President in 2000, opened Senate Judiciary subcommittee hearings on the Clinton administration's doddering encryption policy. Ashcroft lambasted the administration for asking American citizens to turn over crypto keys to the government after it rifled through 1000 raw FBI files seeking political dirt on opponents. 相似文献
7.
LB To N Horvath P Dyson J Henry P Sykes M Brisco A Morley B Bennetts 《Canadian Metallurgical Quarterly》1996,5(5):557-559
Autologous transplantation has been used increasingly over the last 10 years for the treatment of multiple myeloma. As is the case in other cancers treated by high-dose therapy and stem cell rescue, the contribution of occult tumor cells in the graft to relapse posttransplant remains to be resolved. In this report, we review the biology and differentiation of plasma cells in the context of their significance as an origin of relapse in multiple myeloma. 相似文献
8.
There is now strong evidence that the chorioretinal degeneration associated with ornithine-delta-aminotransferase (OAT) deficiency is a consequence of hyperornithinemia. Therefore development of a metabolic system for clearing ornithine from the circulation is being pursued as a potential treatment. The skin is considered an attractive location for such a metabolic system because autologous cells can be safely and easily utilized. This study was undertaken to determine the ornithine metabolizing capacity of epidermal keratinocytes expressing normal and superphysiologic amounts of OAT. The data show that overexpression of OAT in keratinocytes cultured from a gyrate atrophy patient restores ornithine metabolism and results in a rate of ornithine disappearance from the medium that is significantly higher than the rate of disappearance from the medium bathing normal keratinocytes. In addition, OAT activity determined in soluble protein prepared from sonicates suggests that the capacity to maintain plasma ornithine within the normal range is contained within an accomplishable graft of keratinocytes overexpressing OAT. However, the actual rate of ornithine disappearance from the media was significantly less than predicted from enzyme activity assays. Following ornithine metabolite production by intact cells suggests that ornithine metabolism is limited primarily by clearance of downstream metabolites, as opposed to substrate delivery. 相似文献
9.
DC Madsen 《Canadian Metallurgical Quarterly》1993,218(2):219; author reply 219-219; author reply 220
10.
J Bech JK Madsen H Kelbaek K Hvid-Jacobsen K Skagen 《Canadian Metallurgical Quarterly》1996,78(8):871-875
Left ventricular systolic function is reduced during episodes of silent ischemia in patients with coronary artery disease (CAD). Left ventricular ejection fraction (LVEF) is increased at least 5 absolute percent during exercise in most normal subjects; however, in patients with CAD, LVEF often remains unchanged or decreases. The anti-ischemic effect of beta-adrenergic receptor blockade is well documented, including a reduction of exercise-induced electrocardiographic ST depressions; however, the effect of these drugs on left ventricular volume changes during exercise in patients with silent ischemia is unknown. The aim of this study was to evaluate the effect of a cardio-selective beta-blocking agent, metoprolol, on rest and exercise LVEF in patients with silent ischemia, using radionuclide cardiography. Fifteen patients with silent ischemia completed a double-blind, placebo-controlled crossover study at rest and during submaximal exercise. LVEF remained unchanged during exercise in the placebo phase (56% to 58%; p = NS), but even though LVEF tended to decrease 56% during rest after metoprolol versus 52% after placebo (p = NS), the LVEF increase from rest to exercise resembled a normal LVEF response, 52% to 58% (p = 0.005). Exercise-induced electrocardiographic ST depressions were also reduced during metoprolol treatment. In patients with silent ischemia, the exercise-induced change in LVEF rises significantly during metoprolol treatment. The mechanism may be a reduction in myocardial ischemia as indicated by a reduction in ischemic electrocardiographic findings. 相似文献