The effect of short-term lipid infusion on liver function and biliary secretion in rats

This study was undertaken to determine the effect of various lipid emulsions on the hepato-biliary system in rats. Rats were randomly divided into six groups and infused continuously for 48 hr with either long-chain triglycerides (LCT), medium-chain triglycerides (MCT) or a mixture of MCT and LCT. One group infused with physiological saline solution served as controls. Throughout this period the rats received a fat free dietad libitum. During the last hour of lipid infusion bile was collected for determination of bile flow and composition. Subsequently, the rats were sacrificed and the morphology and lipid content of the liver determined. Only LCT lipid emulsions induced morphological changes and increased liver cholesterol content. In two rats infused with radiolabeled LCT, no labeled cholesterol was found in the liver, indicating that the excess hepatic cholesterol level may originate from enhanced cholesterol mobilization to the liver. Biliary cholesterol and phospholipid concentrations in LCT-treated rats were also elevated, as was the lithogenic index, whereas the other emulsions had no such effects. None of the emulsions affected the plasma liver function tests or bile flow. We therefore conclude that the lithogenicity of the bile in rats is directly related to the lipid components of the total parenteral nutrition and the type of triglyceride infused.     

Fermi surface and extended van Hove singularity in the non-cuprate layered perovskite superconductor Sr2RuO4

With high-resolution (22 meV) angle-resolved photoemission spectroscopy, the Fermi surface of the first copper free layered-perovskite superconductor, Sr₂RuO₄, was determined. We observed three bands to cross the Fermi energy in qualitative agreement with LDA band structure calculations; one electron-like surface encircling the point in the projected Brillouin zone, and two hole-like surfaces around the point. The most striking aspect of the measurements is the observation of an extended van Hove singularity. It is located 17 meV below the Fermi energy and extends around the point for about 0.2 Å^–1 along both the — — and the — — directions.These observations demonstrate that van Hove singularities near the Fermi surface are a more generic feature of layered oxides, and call for a clarification of their exact role in oxide superconductivity.We are grateful to D. Singh for making available his band structure calculations. D. H. Lu thanks the VW Foundation for financial support.     

Relationship formation and relational control as correlates of psychotherapy quality and outcome.

This study examined the nature of therapist–client interactions within and across seven psychotherapy cases (a) to test whether therapeutic outcome is a function of a transition from relational incongruence to relational congruence (S. Strong, 1982), and (b) to investigate the relation of relational congruence and control to qualitative aspects of the therapy relationship and to therapy outcome. Measures of therapist and client response patterning served as indices of relational congruence and of relational control. Relationship quality was assessed in terms of therapist and client ratings of their working alliance and of therapy session depth and smoothness. Outcome was operationalized in terms of symptom reduction. Results showed limited support for a relationship between relational congruence and therapy outcome and suggested that relational control is not a significant factor in client or therapist evaluations of relationship quality or therapy outcome. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Fully Symbolic Model Checking of Timed Systems using Difference Decision Diagrams

Current approaches for analyzing timed systems are based on an explicit enumeration of the discrete states and thus these techniques are only capable of analyzing systems with a handful of timers and a few thousand states. We address this limitation by describing how to analyze a timed system fully symbolically, i.e., by representing sets of discrete states and their associated timing information implicitly. We demonstrate the efficiency of the symbolic technique by computing the set of reachable states for a non-trivial timed system and compare the results with the state-of-the-art tools Kronos and Uppaal. With an implementation based on difference decision diagrams, the runtimes are several orders of magnitudes better. The key operation in obtaining these results is the ability to advance time symbolically. We show how to do this efficiently by essentially quantifying out a special variable z which is used to represent the constant zero. The symbolic manipulations given in this paper are sufficient to verify TCTL-formulae fully symbolically.     

Cross validation of the MacNeill-Lichtenberg Decision Tree: Triaging mental health problems in geriatric rehabilitation patients.

Objective: Cross validation of the MacNeill-Lichtenberg Decision Tree (MLDT), a tool for triaging mental health problems in older medical patients. Design: Sensitivity, specificity, and predictive power were calculated for prediction of cognition and depressive symptoms. Correlational analyses were performed to examine the relationship between demographic variables and MLDT measures. Correlational and logistic regression analyses were conducted to examine the utility of the cognitive component of the MLDT. Setting: A freestanding urban, university-affiliated rehabilitation hospital in the Midwest. Participants: One hundred eighty-seven elderly, predominantly African American medical rehabilitation patients who lived alone before hospitalization. Main Outcome Measure: The MLDT was compared with the Mattis Dementia Rating Scale and the 30-item Geriatric Depression Scale. Results: The cognitive component of the MLDT demonstrated high positive and negative predictive value; the affective component evidenced excellent negative predictive value. Conclusions: These findings are consistent with previous research and provide further evidence of the utility of the MLDT… (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Subacute rehabilitation: New opportunities and challenges for rehabilitation psychologists.

Changes in the health care delivery system have obliged rehabilitation service providers to consider alternatives to the traditional model of comprehensive acute inpatient rehabilitation. An option of growing popularity among third-party payers is subacute rehabilitation. This type of rehabilitation is usually provided within a skilled nursing home, provides fewer hours of therapeutic intervention, and uses less professional staff, but may achieve similar outcomes. As subacute rehabilitation has grown, rehabilitation psychologists have been used in these settings, but uncertainties exist as to appropriate roles and reimbursement opportunities. This article provides a framework for understanding the current status of subacute rehabilitation as a part of the rehabilitation continuum of care and how rehabilitation psychologists can maximize their effectiveness in this environment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Competency assessment models.

This article describes characteristics of alternative assessment models deployed in the measurement of professional competencies across the professional life span based on the work of the American Psychological Association Task Force on the Assessment of Competence in Professional Psychology. Assessments of knowledge, decision making, performance and personal attributes, as well as integrated practice-based skills and tasks are described and compared on the basis of their validity, feasibility and practicality, fidelity, and relevance at difference stages of professional development. It is acknowledged that no single assessment can evaluate all competencies and that assessments can be combined in complementary ways. Assessments deployed in the nursing, dental, and medical professions are reviewed and contrasted with current practices in psychology. At the licensure level, differences in the assessments deployed among the 4 healthcare professions are described, and their candidate fees and number of candidates assessed annually are documented. Ideas for developing new assessments in psychology are discussed on the basis of the needs and financial resources available to psychology and the experiences of other healthcare professions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cost-effectiveness of transaxillary muscle-sparing same-day operative closure of patent ductus arteriosus

Transaxillary muscle-sparing patent ductus arteriosus closure performed as same-day surgery is described in 10 patients. This approach provides a superb cosmetic result while obviating the need for thoracostomy tube placement.     

Investigation of reported anomalies in the electrotransport of interstitial solutes in titanium and iron

The electric mobilities, effective valences, and diffusivities of carbon, nitrogen, and oxygen in β-titanium were measured in the temperature range of 1335 to 1575°C. The effective valence, Z*, of carbon was determined to be positive and nitrogen and oxygen to be negative, thus confirming a previously reported anomaly in the electrotransport behavior of carbon in titanium. A similar anomaly in the effective charge of nitrogen in γ iron was also investigated. The previously reported negativeZ* value was not supported by the results of this investigation. PositiveZ* values were obtained for nitrogen in both α and γ iron in agreement with those for carbon in these two phases. An analytical method of solving for the various transport parameters was used in this investigation. A mathematical proof of the method and the treatment of errors is described in the paper.