Task Switching After Cerebellar Damage.

The authors of this study investigated task switching following cerebellar damage. The study group consisted of 7 children and adolescents (M age = 13.8 years) who underwent surgical removal of a benign posterior fossa tumor. They were tested at a sufficient interval after surgery (M lag = 6.13 years) for restoration of normal cognitive skills and intelligence. Although all showed normal learning of the task compared with control participants, when rapid behavioral changes were required (short preparation time), they exhibited behavioral rigidity manifested by enhanced switching cost. These results are in line with another study on serial reaction time with the same patients (A. Berger et al., in press). They have important implications for our understanding of the cognitive sequelae of early cerebellar damage as well as the involvement of the cerebellum in task switching. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sense and nonsense in hierarchical regression analysis: Comment on Smyth.

Contrasts ANCOVA via hierarchical regression analysis with hierarchical analyses used by L. D. Smyth (see record 1983-07281-001) in his article on psychopathology as a function of neuroticism. It is shown that Smyth's analyses did not address the hypotheses he wished to test and that the results yielded by these analyses are meaningless. (8 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dimensionality of disability labels.

Studied the perceptions of disabilities by using more comprehensive stimulus sets and a less constraining response mode. 73 respondents (mean age 38.24 yrs) sorted 35 disability labels on the basis of their similarity. The dimensionality of this large stimulus set was studied through the use of multidimensional scaling. A 4-dimensional solution accounting for 58% of the variance was retained. The dimensions were physical disabilities, behavioral-emotional vs cognitive disabilities, specific vs diffuse disabilities, and visibility. This comprehensive structure underlying perceptions of disabilities is discussed in relation to previous findings. (34 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Bubonic plague,colonial ideologies,and urban planning policies: Dakar,Lagos, and Kumasi

The Third Plague Pandemic originated in Southwest China in the mid-nineteenth century, reached Africa's shores around 1900, and spread globally for about a century. This article examines three plague loci in colonial Senegal (Dakar, 1914), Nigeria (Lagos, 1924), and the Gold Coast (today's Ghana; Kumasi, 1924). A tripartite comparative analysis is made of French and British doctrines of colonial rule, colonial urban planning policies, and anti-plague practices. While some common features are demonstrated in the policies and practices of the colonizing forces such as the implementation of rigorous measures and embracing segregationist solutions, divergent features can also be distinguished. These relate to the methods of implementation of planning and anti-plague policies, in accordance with colonial ideology (assimilation, direct and indirect rule); and to the very nature of autochthonous communities, responses, and levels of agitation. Our both comparative and more nuanced site-related view is also based on a large collection of archival and secondary materials from multilateral channels.     

The β2-Subunit (AMOG) of Human Na+, K+-ATPase Is a Homophilic Adhesion Molecule

The β₂ subunit of Na⁺, K⁺-ATPase was originally identified as the adhesion molecule on glia (AMOG) that mediates the adhesion of astrocytes to neurons in the central nervous system and that is implicated in the regulation of neurite outgrowth and neuronal migration. While β₁ isoform have been shown to trans-interact in a species-specific mode with the β₁ subunit on the epithelial neighboring cell, the β₂ subunit has been shown to act as a recognition molecule on the glia. Nevertheless, none of the works have identified the binding partner of β₂ or described its adhesion mechanism. Until now, the interactions pronounced for β₂/AMOG are heterophilic cis-interactions. In the present report we designed experiments that would clarify whether β₂ is a cell–cell homophilic adhesion molecule. For this purpose, we performed protein docking analysis, cell–cell aggregation, and protein–protein interaction assays. We observed that the glycosylated extracellular domain of β₂/AMOG can make an energetically stable trans-interacting dimer. We show that CHO (Chinese Hamster Ovary) fibroblasts transfected with the human β₂ subunit become more adhesive and make large aggregates. The treatment with Tunicamycin in vivo reduced cell aggregation, suggesting the participation of N-glycans in that process. Protein–protein interaction assay in vivo with MDCK (Madin-Darby canine kidney) or CHO cells expressing a recombinant β₂ subunit show that the β₂ subunits on the cell surface of the transfected cell lines interact with each other. Overall, our results suggest that the human β₂ subunit can form trans-dimers between neighboring cells when expressed in non-astrocytic cells, such as fibroblasts (CHO) and epithelial cells (MDCK).     

Decomposition of adsorbed VX on activated carbons studied by 31P MAS NMR

The fate of the persistent OP nerve agent O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate (VX) on granular activated carbons that are used for gas filtration was studied by means of 31P magic angle spinning (MAS) NMR spectroscopy. VX as vapor or liquid was adsorbed on carbon granules, and MAS NMR spectra were recorded periodically. The results show that at least 90% of the adsorbed VX decomposes within 20 days or less to the nontoxic ethyl methylphosphonic acid (EMPA) and bis(S-2-diisopropylaminoethane) {(DES)2}. Decomposition occurred irrespective of the phase from which VX was loaded, the presence of metal impregnation on the carbon surface, and the water content of the carbon. Theoretical and practical aspects of the degradation are discussed.     

Attitudes toward people with disabilities: The perspective of attachment theory.

Objective: Attachment theory was employed as the theoretical framework for the purpose of examining attitudes toward people with disabilities. Method: A total of 404 Jewish Israeli students without disabilities completed the Multidimensional Attitudes Scale Toward Persons With Disabilities (MAS) and the Experiences in Close Relationships Scale (ECR). Results: Reading a scenario about an encounter with a person with a disability gave rise to more negative emotions than reading a similar scenario about an encounter with a person without a disability, regardless of participants' attachment orientations. However, attachment orientations moderated participants' positive cognitions and distancing behaviors. Conclusions: Findings suggest a dynamic process of self-regulation when reacting to a written scenario about people with disabilities. This process consists of an initial spontaneous negative emotional response accompanied by compensatory positive cognitions and behavioral tendencies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Patients' information needs and decision-making processes: What can be learned from genetic counselees?

This field study investigated the information needs and decision-making strategies of 161 genetic counselees interviewed just prior to counseling. Patients were interested mostly in information about the outcomes and consequences of the alternative options at their disposal and about measures to defuse the risks. They wanted mainly information stated with certainty and were less interested in probability information. There was no difference in the search for information between the alternative eventually chosen and the one not chosen. There was a difference, however, among types of decisions and the interest in the various categories of information. These findings were interpreted within the theoretical model of decision making in natural risky situations (O. Huber, 1997). Practical implications for shared medical decision making are presented. (PsycINFO Database Record (c) 2010 APA, all rights reserved)