Career Benefits Associated With Mentoring for Proteges: A Meta-Analysis.

Meta-analysis was used to review and synthesize existing empirical research concerning the career benefits associated with mentoring for the protege. Both objective (e.g., compensation) and subjective (e.g., career satisfaction) career outcomes were examined. Comparisons of mentored versus nonmemored groups were included, along with relationships between mentoring provided and outcomes. The findings were generally supportive of the benefits associated with mentoring, but effect sizes associated with objective outcomes were small. There was also some indication that the outcomes studied differed in the magnitude of their relationship with the type of mentoring provided (i.e.. career or psychosocial). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A model for the evaluation of environmental impact indicators for a sustainable maritime transportation systems

Maritime shipping is considered the most efficient, low-cost means for transporting large quantities of freight over significant distances. However, this process also causes negative environmental and societal impacts. Therefore, environmental sustainability is a pressing issue for maritime shipping management, given the interest in addressing important issues that affect the safety, security, and air and water quality as part of the efficient movement of freight throughout the coasts and waterways and associated port facilities worldwide. In-depth studies of maritime transportation systems (MTS) can be used to identify key environmental impact indicators within the transportation system. This paper develops a tool for decision making in complex environments; this tool will quantify and rank preferred environmental impact indicators within a MTS. Such a model will help decision-makers to achieve the goals of improved environmental sustainability. The model will also provide environmental policy-makers in the shipping industry with an analytical tool that can evaluate tradeoffs within the system and identify possible alternatives to mitigate detrimental effects on the environment.     

Engineering towards Nitroreductase Functionality in Ene‐Reductase Scaffolds

Nitroreductases (NRs) and ene‐reductases (ERs) both utilize flavin mononucleotide cofactors but catalyze distinct reactions. NRs reduce nitroaromatics, whereas ERs reduce unsaturated C?C double bonds, and these functionalities are known to somewhat overlap. Recent studies on the ER xenobiotic reductase A (XenA) from Pseudomonas putida demonstrated the possibility of increasing NR activity with active site modifications. Structural comparison between NRs and ERs led us to hypothesize that active site cavity size plays an important role in determining enzyme functionality. Residues of ER KYE1 from Kluyveromyces lactis were selected to increase the binding pocket size, compensate for hydrogen bonding pattern changes, and eliminate ER activity. Single variants were screened, and promising mutations were combined. Variant F296A/Y275A showed a 100‐fold improvement in NR specific activity over wild‐type, and variant H191A/F296A/Y375A exhibited complete conversion to a NR.