Understanding the role of impulsivity and externalizing psychopathology in alcohol abuse: Application of the UPPS Impulsive Behavior Scale.

The present study explores the relation among 4 personality traits associated with impulsive behavior and alcohol abuse. Personality traits were measured using the 4 subscales of the UPPS Impulsive Behavior Scale (UPPS: S. P. Whiteside & D. R. Lynam. 2001). The UPPS and measures of psychopathology were administered to clinical samples of alcohol abusers high in antisocial personality traits (AAPD), alcohol abusers low in antisocial personality traits (AA), and a control group (total N = 60). Separate analyses of variance indicated that AAPDs had significant elevations on all 4 UPPS scales, whereas the AAs and controls differed only on the Urgency subscale. However, when controlling for psychopathology, group differences on the UPPS scales disappeared. The results suggest that personality traits related to impulsive behavior are not directly related to alcohol abuse but rather are associated with the elevated levels of psychopathology found in a subtype of alcohol abusers. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Adaptive modelling for adaptive water quality management in the Great Barrier Reef region,Australia

The development and use of a Bayesian Belief Network (BBN) model, within an adaptive management process for the management of water quality in the Mackay Whitsunday region of Queensland, Australia is described. The management goal is firstly to set achievable targets for water quality entering the Great Barrier Reef lagoon from the Mackay Whitsunday natural resource management region and then secondly to define and implement a strategy to achieve these targets. The BBN serves as an adaptive framework that managers and scientists may use to articulate what they know about the managed system. It then provides a tool to guide where, when and what interventions (including research) are most likely to achieve management outcomes. Importantly the BBN provides a platform for collective learning.BBN estimates of total suspended sediment (TSS) loads and event mean concentrations (EMCs) were compared to observed data and results from current best practice models. The BBN estimates were reasonable relative to empirical observations. Example results from the BBN are thereafter used to illustrate the use of the model in estimating the likelihood of exceeding water quality targets with and without proposed actions to improve water quality. Example results are also used to illustrate what spatial or land use elements might contribute most to exceeding water quality targets. Finally key limitations of the tool are discussed and important learnings from the process are highlighted.     

Longitudinal evidence that psychopathy scores in early adolescence predict adult psychopathy.

This study examined the relation between psychopathy assessed at age 13 by using the mother-reported Childhood Psychopathy Scale (D. R. Lynam, 1997) and psychopathy assessed at age 24 by using the interviewer-rated Psychopathy Checklist: Screening Version (PCL:SV; S. D. Hart, D. N. Cox, & R. D. Hare, 1995). Data from over 250 participants of the middle sample of the Pittsburgh Youth Study were used to examine this relation; approximately 9% of the sample met criteria for a possible PCL:SV diagnosis. Despite the long time lag, different sources, and different methods, psychopathy from early adolescence into young adulthood was moderately stable (r=.31). The relation was present for the PCL:SV total and facet scores, was not moderated by initial risk status or initial psychopathy level, and held even after controlling for other age 13 variables. Diagnostic stability was somewhat lower. Both specificity and negative predictive power were good, and sensitivity was adequate, but positive predictive power was poor. This constitutes the first demonstration of the relative stability of psychopathy from adolescence into adulthood and provides evidence for the incremental utility of the adolescent psychopathy construct. Implications and future directions are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Evidence for a third component in neutrophil aggregation: potential roles of O-linked glycoproteins as L-selectin counter-structures

The homotypic aggregation of neutrophils requires the participation of L-selectin and the beta 2-integrins, but it has not been clear whether the two receptors recognize one another as counter-structures or whether other adhesion molecules are involved. We have examined aggregation of live neutrophils with target populations, manipulated to alter expression of adhesive epitopes, using flow cytometry. A target population depleted of both L-selectin and activatable beta 2-integrin displayed an ability to aggregate with live neutrophils, suggesting that these two molecules are not counter-structures. We also found that an O-sialoglycoprotease (GCP) from Pasteurella haemolytica is capable of inhibiting homotypic aggregation. Neutrophils treated with GCP lose O-glycosylated proteins but retain L-selectin and activatable beta 2-integrin. One or more of the GCP substrates appears to function in L-selectin-dependent binding but not in beta 2-integrin-dependent binding. Together the data suggest a mechanism of aggregation that is analogous to leukocyte-endothelial cell adhesion in which a low-affinity carbohydrate-dependent interaction precedes a high-affinity integrin-dependent adhesion.     

Carbon nanotube-based transducers for immunoassays

The attachment of mouse immunoglobulin G (IgG) and anti-mouse IgG antibodies onto carbon nanotubes (CNTs), using either non-covalent or covalent means was investigated. The resultant CNTs were characterised using a variety of techniques including enzyme-linked and fluorescence-linked immunoassays, UV-visible-NIR and Raman spectroscopy, transmission electron microscopy and cyclic voltammetry. TEM images of the adsorbed antibody on the CNTs show that the covalent modification approach was successful, whereas the non-covalent approach resulted in no electrochemically detectable labelled antibody. Direct electrical communication between CNTs covalently linked to peroxidase-labelled antibodies was observed during cyclic voltammetry, which suggests applications in developing carbon-nanotube-based immunosensors.     

Assessing the basic traits associated with psychopathy: Development and validation of the Elemental Psychopathy Assessment.

A new self-report assessment of the basic traits of psychopathy was developed with a general trait model of personality (five-factor model [FFM]) as a framework. Scales were written to assess maladaptive variants of the 18 FFM traits that are robustly related to psychopathy across a variety of perspectives including empirical correlations, expert ratings, and translations of extant assessments. Across 3 independent undergraduate samples (N = 210–354), the Elemental Psychopathy Assessment (EPA) scales proved to be internally consistent and unidimensional, and were strongly related to the original FFM scales from which they were derived (mean convergent r = .66). The EPA scales also demonstrated substantial incremental validity in the prediction of existing psychopathy measures over their FFM counterparts. When summed to form a psychopathy total score, the EPA was substantially correlated with 3 commonly used psychopathy measures (mean r = .81). Finally, in a small male forensic sample (N = 70), the EPA was significantly correlated with scores on a widely used self-report psychopathy measure, disciplinary infractions, alcohol use, and antisocial behavior. The EPA provides an opportunity to examine psychopathy and its nomological network through smaller, more basic units of personality rather than by scales or factors that blend these elements. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Testing the relations between impulsivity-related traits, suicidality, and nonsuicidal self-injury: A test of the incremental validity of the UPPS model.

Borderline personality disorder (BPD) has received significant attention as a predictor of suicidal behavior (SB) and nonsuicidal self-injury (NSSI). Despite significant promise, trait impulsivity has received less attention. Understanding the relations between impulsivity and SB and NSSI is confounded, unfortunately, by the heterogeneous nature of impulsivity. This study examined the relations among 4 personality pathways to impulsive behavior studied via the UPPS model of impulsivity and SB and NSSI in a residential sample of drug abusers (N = 76). In this study, we tested whether these 4 impulsivity-related traits (i.e., Negative Urgency, Sensation Seeking, Lack of Premeditation, and Lack of Perseverance) provide incremental validity in the statistical prediction of SB and NSSI above and beyond BPD; they do. We also tested whether BPD symptoms provide incremental validity in the prediction of SB and NSSI above and beyond these impulsivity-related traits; they do not. In addition to the main effects of Lack of Premeditation and Negative Urgency, we found evidence of a robust interaction between these 2 personality traits. The current results argue strongly for the consideration of these 2 impulsivity-related domains—alone and in interaction—when attempting to understand and predict SB and NSSI. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Delinquency and impulsivity and IQ: A reply to Block (1995).

Although J. Block's critique (see record 1995-29649-001) of the D. Lynam, T. Moffitt, and M. Stouthamer-Loeber report (see record 1993-29924-001) contains several interesting points, many of his criticisms are not valid and resulted from miscommunications, misunderstandings, and simple preferences. Specifically, the authors believe the criticisms to be the results of mistaking a single hypothesis for an organizing principle, a misunderstanding of the reported path analyses, and a simple preference for impulsivity over IQ as an explanatory construct. An attempt is made to address the misinterpretation through clarification of the predicted relations between IQ, executive dysfunction, impulsivity, and delinquency. The original path analyses are reviewed and are shown to refute not only the original self-control hypothesis (Lynam et al., 1993), as reported, but also Block's more recent version. Finally, evidence marshalled by Block to support his emphasis on impulsive personality over low IQ is argued to have inadequacies from empirical and social policy perspectives. (PsycINFO Database Record (c) 2010 APA, all rights reserved)