Laser therapy of Barrett''s mucosa

Midden and Dahl, in a recent paper, have presented important data on the inactivation of bacteria by singlet oxygen. In analyzing the data, use was made of a theory published earlier by the present author. The purpose of this paper is to point out that theory and experiment can be brought into better agreement by assuming that the interaction of singlet oxygen with the bacteria takes place in an essentially lipid environment rather than aqueous.     

Scanning laser photostimulation: a new approach for analyzing brain circuits

A new technique for understanding the organization of complex circuits in the vertebrate brain, scanning laser photostimulation, is described. This approach is based on the photolysis of a caged form of the excitatory neurotransmitter glutamate. Computer-controlled photostimulation and whole cell recording in brain slices allow the construction of detailed maps of the position, strength, sign and number of inputs converging on a single postsynaptic neuron. Scanning laser photostimulation offers many advantages over current techniques: spatial resolution is superb, fibers of passage are not activated, and thousands of presynaptic locations can be stimulated. This review describes the technique of photostimulation, outlines the instrumentation, necessary to implement it, and discusses the interpretation of photostimulation-derived data. Several examples of applications, ranging from mapping circuits in the mammalian visual cortex to determining receptor distributions on single neurons are considered. Although still in its early stages, scanning laser photostimulation offers neuroscientists a powerful tool for determining the organization and function of local brain circuits.     

Inheritance of male hybrid sterility in the house musk shrew (Suncus murinus, Insectivora, Soricidae)

Two geographic races of the house musk shrew (Suncus murinus) were crossed and intercrossed in the laboratory. Many cases of male sterility were detected among the hybrids. Segregation analysis of the pedigree data showed that the inheritance of male sterility in interracial hybrids of S. murinus can be described within the framework of monogene polyallele model with sterility of a single allele combination. This model is similar if not identical to that proposed by Dobzhansky and Muller.     

Evaluating medication response in ADHD: cognitive, behavioral, and single-subject methodology

We introduce a novel application for linkage analysis: using bone marrow donor-recipient sib pairs to search for genes influential in graft-versus-host disease (GVHD), a major cause of morbidity and mortality following allogeneic bone marrow transplantation. In particular, we show that transplant sib pairs in which the recipient developed severe GVHD can be used to map genes in the same way as traditional discordant (affected/unaffected) sib pairs (DSPs). For a plausible GVHD model, we demonstrate that the transplant/discordant sib pair analog of the "possible triangle test" [Holmans (1993) Am J Hum Genet 52:362-374] has similar power to that of the simpler "restricted test" proposed by Risch [(1990b) Am J Hum Genet 46:229-241; (1992) Am J Hum Genet 51:673-675]. Moreover, we show that the restricted test has superior power in much of the DSP possible triangle and significantly inferior power in only a small region. Thus, we conclude that the restricted test is preferable for localizing genes with transplant/discordant sib pairs. Finally, we examine the effects of heterogeneity on the power to detect GVHD loci and demonstrate the gain in efficiency by dividing the sample into genetically more homogeneous subgroups.     

Keyboard design through physiological strain measurements

The physiologically tolerable range of positions for the joints of the upper extremities have been investigated for typing tasks by recording the myoelectric activities of the involved muscles. For long-term typing tasks a split keyboard is recommended allocating a key field to each hand. The fields should be rotated against each other in the horizontal plane and inclined laterally.     

Gossip-based ad hoc routing

Many ad hoc routing protocols are based on some variant of flooding. Despite various optimizations of flooding, many routing messages are propagated unnecessarily. We propose a gossiping-based approach, where each node forwards a message with some probability, to reduce the overhead of the routing protocols. Gossiping exhibits bimodal behavior in sufficiently large networks: in some executions, the gossip dies out quickly and hardly any node gets the message; in the remaining executions, a substantial fraction of the nodes gets the message. The fraction of executions in which most nodes get the message depends on the gossiping probability and the topology of the network. In the networks we have considered, using gossiping probability between 0.6 and 0.8 suffices to ensure that almost every node gets the message in almost every execution. For large networks, this simple gossiping protocol uses up to 35% fewer messages than flooding, with improved performance. Gossiping can also be combined with various optimizations of flooding to yield further benefits. Simulations show that adding gossiping to AODV results in significant performance improvement, even in networks as small as 150 nodes. Our results suggest that the improvement should be even more significant in larger networks.     

Psychology at the Intersection of Work and Family: Recommendations for Employers, Working Families, and Policymakers.

Demographic data show that major changes have been occurring in the everyday lives of families over the last generation, with the majority of mothers of young children in the workforce and an increasing number of men and women assuming caregiving responsibilities for older relatives. Thus, the 2 primary identities of most adults, defined by their multiple family and work roles, need to be coordinated in ways that promote positive family outcomes, returns on investments for employers, and societal values. Despite changes in the workforce, the world of work is still largely organized for a family model that is increasingly rare--one with a stay-at-home caregiver. Recommendations based on psychological and other social science research are offered to align the needs of working families and employers. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Reasoning about Knowledge: A Response by the Authors

Minds and Machines -