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1.
M. R. Thompson 《Drug development and industrial pharmacy》2015,41(8):1223-1231
Twin screw granulation (TSG) is a new process of interest to the pharmaceutical community that can continuously wet granulate powders, doing so at lower liquid concentrations and with better product consistency than found by a high shear batch mixer. A considerable body of research has evolved over the short time since this process was introduced but generally with little comparison of results. A certain degree of confidence has been developed through these studies related to how process variables and many attributes of machinery configuration will affect granulation but some major challenges still lay ahead related to scalability, variations in the processing regimes related to degree of channel fill and the impact of wetting and granulation of complex powder formulations. This review examines the current literature for wet granulation processes studied in twin screw extrusion machinery, summarizing the influences of operational and system parameters affecting granule properties as well as strives to provide some practical observations to newly interested users of the technique. 相似文献
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M. J. O’Sullivan C. G. Walker M. L. O’Sullivan T. D. Thompson A. B. Philpott 《Telecommunication Systems》2006,33(4):353-376
The problem of designing fibre-optic networks for local-access telecommunications generates (at least) three non-trivial subproblems.
In the first of these subproblems one must determine how many fibre-optic cables (fibres) are required at either end of a
street. In the next subproblem a minimum-cost network must be designed to support the fibres. The network must also provide
distinct paths from either end of the street to the central exchange(s). Finally, the fibre-optic cables must be placed in
protective covers. These covers are available in a number of different sizes, allowing some flexibility when covering each
section of the network. In this paper we describe a dynamic programming (DP) formulation for finding a minimum-cost (protective)
covering for the network (the third of the subproblems). This problem is a generalised set covering problem with side constraints
and is further complicated by the introduction of fixed and variable welding costs. The DP formulation selects covers along
each arc (in the network), but cannot exactly model the fixed costs and so does not guarantee optimality. We also describe
an integer programming (IP) formulation for assessing the quality of the DP solutions. The cost of the networks constructed
by the IP model is less than those designed using the DP model, but the saving is not significant for the problems examined
(less than 0.1%). This indicates that the DP model will generally give very good solutions. Furthermore, as the problem dimensions
grow, DP gives significantly better solution times than IP. 相似文献
4.
B. Ma P.I. Djurovich S. Garon B. Alleyne M.E. Thompson 《Advanced functional materials》2006,16(18):2438-2446
Efficient blue‐, green‐, and red‐light‐emitting organic diodes are fabricated using binuclear platinum complexes as phosphorescent dopants. The series of complexes used here have pyrazolate bridging ligands and the general formula C∧NPt(μ‐pz)2PtC∧N (where C∧N = 2‐(4′,6′‐difluorophenyl)pyridinato‐N,C2′, pz = pyrazole ( 1 ), 3‐methyl‐5‐tert‐butylpyrazole ( 2 ), and 3,5‐bis(tert‐butyl)pyrazole ( 3 )). The Pt–Pt distance in the complexes, which decreases in the order 1 > 2 > 3 , solely determines the electroluminescence color of the organic light‐emitting diodes (OLEDs). Blue OLEDs fabricated using 8 % 1 doped into a 3,5‐bis(N‐carbazolyl)benzene (mCP) host have a quantum efficiency of 4.3 % at 120 Cd m–2, a brightness of 3900 Cd m–2 at 12 V, and Commission Internationale de L'Eclairage (CIE) coordinates of (0.11, 0.24). Green and red OLEDs fabricated with 2 and 3 , respectively, also give high quantum efficiencies (~ 6.7 %), with CIE coordinates of (0.31, 0.63) and (0.59, 0.46), respectively. The current‐density–voltage characteristics of devices made using dopants 2 and 3 indicate that hole trapping is enhanced by short Pt–Pt distances (< 3.1 Å). Blue electrophosphorescence is achieved by taking advantage of the binuclear molecular geometry in order to suppress dopant intermolecular interactions. No evidence of low‐energy emission from aggregate states is observed in OLEDs made with 50 % 1 doped into mCP. OLEDs made using 100 % 1 as an emissive layer display red luminescence, which is believed to originate from distorted complexes with compressed Pt–Pt separations located in defect sites within the neat film. White OLEDs are fabricated using 1 and 3 in three different device architectures, either with one or two dopants in dual emissive layers or both dopants in a single emissive layer. All the white OLEDs have high quantum efficiency (~ 5 %) and brightness (~ 600 Cd m–2 at 10 V). 相似文献
5.
Life is pleasant--and memory helps to keep it that way! 总被引:1,自引:0,他引:1
Walker W. Richard; Skowronski John J.; Thompson Charles P. 《Canadian Metallurgical Quarterly》2003,7(2):203
People's recollections of the past are often positively biased. This bias has 2 causes. The 1st cause lies in people's perceptions of events. The authors review the results of several studies and present several new comparative analyses of these studies, all of which indicate that people perceive events in their lives to more often be pleasant than unpleasant. A 2nd cause is the fading affect bias: The affect associated with unpleasant events fades faster than the affect associated with pleasant events. The authors review the results of several studies documenting this bias and present evidence indicating that dysphoria (mild depression) disrupts such bias. Taken together, this evidence suggests that autobiographical memory represents an important exception to the theoretical claim that bad is stronger than good. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
Math1 is essential for genesis of cerebellar granule neurons 总被引:1,自引:0,他引:1
N Ben-Arie HJ Bellen DL Armstrong AE McCall PR Gordadze Q Guo MM Matzuk HY Zoghbi 《Canadian Metallurgical Quarterly》1997,390(6656):169-172
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W. S. Walston I. M. Bernstein A. W. Thompson 《Metallurgical and Materials Transactions A》1991,22(6):1443-1451
The microstructure of a single-crystal nickel-base superalloy, PWA 1480, has been varied by heat treatment and hot isostatic
pressing in order to study the role of the γ/yγ′ eutectic and porosity on subsequent tensile behavior. The level of porosity
was found not to affect any of the tensile properties, while the γ/γ′ eutectic strongly influenced ductility. Eliminating
the γ/γ′ eutectic increased ductility which was attributed to the cleavage fracture of this constituent. It is proposed that
such cleavage of the γ/γ′ eutectic is initiated by the stress created from impinging slip bands, promoting shear localization,
and final fracture along {111} slip planes. The precise nature of this fracture process is discussed with emphasis on the
role of the γ/′ micro-structure. The deformation structure of PWA 1480 was also studied, and while different in some respects
from many other single-crystal superalloys, its fracture process appears to be similar.
Formerly Graduate Student, Department of Metallurgical Engineering and Materials Science, Carnegie Mellon University. 相似文献