Measles, polio and tetanus toxoid antibody levels in Gambian children aged 3 to 4 years following routine vaccination

A nation-wide cross-sectional survey of 816 children 3-4 years old was carried out in The Gambia between September 1990 and July 1991 to assess the seroprevalence of antibodies against 3 diseases included in the expanded programme on immunization: measles, poliomyelitis and tetanus. Among 689 children whose records were available, 94.5% were fully immunized. Measles vaccine was administered to 97% of the children and 91% of these had detectable antibodies at the time of the survey. Antibodies against type 1 and type 3 polioviruses, after up to 6 doses of oral polio vaccine, were present in 88.1% and 89.3% of the children respectively. Ninety-seven percent of the children who had received 4 doses of diphtheria-pertussis-tetanus vaccine (DPT) and 91% of those who received 3 doses had detectable tetanus toxoid antibodies at the age of 3-4 years. This study shows that serological responses to EPI vaccines given in infancy persist at very satisfactory levels throughout early childhood.     

P distribution in different sediment fraction of a constructed wetland

The aim of this work was to study the accumulation and fractionation of P in the inlet and outlet sediment of a constructed wetland for the wastewater treatment of a metallurgic plant in Argentina. It was important to predict whether P could be released into the water again by changing environmental conditions or retained over time. P-fractionation was performed using a sequential extraction method. Sediment cores were sliced at depths of: 0-3; 3-7 and 7-10 cm. Sediment showed high pH values and anoxic conditions. In the inlet area, P was principally bound to the carbonate fraction, whereas in the outlet area, it was mainly bound in the residual fraction. This behavior was justified by the effluent composition, which is rich in Ca2+ and Fe3+ and presents high values of pH and conductivity. These conditions favor CaCO3 and Fe(OOH)n precipitation and the subsequent sorption of P to their surface. The sediment active layer involved in the exchange reactions was the superficial one (0-3 cm). The wetland is highly efficient in P retention. P was retained by sediment in fractions that will not release it to the water while chemical and environmental conditions of the system are maintained.     

The use of Haemophilus influenzae type b-tetanus toxoid conjugate vaccine mixed with diphtheria-tetanus-pertussis vaccine in Gambian infants

In preparation for an efficacy trial of PRP-T Haemophilus influenzae type b conjugate vaccine, 251 Gambian infants were randomized to receive three doses of PRP-T and diphtheria-tetanus-pertussis (DTP) vaccines at 2, 3 and 4 months of age, either by separate injections, or combined in the same syringe. One month after the third dose, there was no difference between anti-PRP levels in those infants who received the vaccines separately (GMT 5.83 micrograms ml-1), and those who received the vaccines combined (GMT 5.57 micrograms ml-1). The proportions achieving levels of 1.0 microgram ml-1 were 89% and 92% in the "separate" and "combined" vaccine groups, respectively. There were no significant differences between groups in levels of antibody to diphtheria or tetanus. Geometric mean titres of antibody directed against pertussis antigens in the "separate" and "combined" groups were as follows: pertussis toxin 14.2 and 13.1 ELISA units (EU) ml-1; filamentous haemagglutinin 12.2 and 9.7 EU ml-1; pertactin 17.2 and 9.0 EU ml-1 (P < 0.05), fimbrial 2/3 antigens 449 and 364 EU ml-1. The combination of PRP-T and DTP in the syringe prior to administration is safe and immunogenic. The lower levels of anti-pertussis antibody are of unknown clinical significance.     

High-Speed Tools for Global Information Management.II. Specifications and Uses of the Transparent Query Language (TQL) Part IIF. Additional Uses of TQL, Data Structures, Concise Definitions, Conclusions and Acknowledgments

This part, PART IIF [6], concludes the document HIGH-SPEED TOOLS FOR GLOBAL INFORMATION MANAGEMENT. II. Specifications and Uses of the Transparent Query Language (TQL) [1–6]. It describes novel applications of TQL, the key data structures, and contains a dictionary of Transparent Query Language terms. PART IIF references PART IIA [1], PART IIB [2], PART IIC [3], PART IID [4], and PART IIE [5] and contains Conclusions and Acknowledgements.     

Paleomagnetic evidence of a low-temperature origin of carbonate in the Martian meteorite ALH84001

Indirect evidence for life on Mars has been reported from the study of meteorite ALH84001. The formation temperature of the carbonates is controversial; some estimates suggest 20 degrees to 80 degrees C, whereas others exceed 650 degrees C. Paleomagnetism can be used to distinguish between these possibilities because heating can remagnetize ferrimagnetic minerals. Study of two adjacent pyroxene grains from the crushed zone of ALH84001 shows that each possesses a stable natural remanent magnetization (NRM), implying that Mars had a substantial magnetic field when the grains cooled. However, NRM directions from these particles differ, implying that the meteorite has not been heated significantly since the formation of the internal crushed zone about 4 billion years ago. The carbonate globules postdate this brecciation, and thus formed at low temperatures.     

A Transportable Programming Language (TPL) System. I. overview

A Transportable Programming Language, TPL, is defined as one that can be used to codeany program that will compile and correctly execute onany machine in a designated range. The range specifies only the minimum software and hardware needed to support the TPL. A HLL-TPL System is one that, in addition to supporting the TPL, can be used to transport any program coded in a dialect of the High-Level Language, HLL, so that it will compile and correctly execute on any machine in a designated range.Methods of implementing a HLL-TPL System are reviewed and it is demonstrated that theSuperset Method, in which the Hypothetical Parent of the HLL (HPHLL) acts as the intermediate language between the dialects of a HLL, leads to a fully transportable High-Level Language—the HPHLL—whose only parameters are: The amount of memory available; and the maximum module size exclusive of arrays. The ongoing work to realize a production version of the FORTRAN-TPL system is described. Its essential characteristic is a fully transportable bifunctional FORTRAN-TPL compiler that converts a dialect of FORTRAN to the intermediate language, HPFORTRAN, and visa-versa.     

High-speed tools for Global Information Management I. Information processing and retrieval

The general specifications and design for a High-Speed General Information Management System, HSGIMS, to serve as the basis for a Global Information Network are given. Some of the key specifications that have been confirmed in experiments with a prototype of the HSGIMS are:

1. Information (or data) and Question-type (or logical data) independence.
2. Very small bounded search times that are independent of the amount of information that is managed and can be computed exactly.
3. A fool-proof security system that can be used to protect databases against viruses and can also be easily invoked to deny unauthorized access by users.
4. Efficient use of all storage and communications resources.

     

The value of solar: Prices and output from distributed photovoltaic generation in South Australia

The Australian government's Solar Cities Program sees great value in so-called “cost-reflective pricing”, code for valuing solar at pool prices. We test that proposition in South Australia where pool prices and insolation are often high and we show that there were few days in 2004 when the pool price gives better outcomes than if the solar is valued at the regulated and fixed, so-called standing contract price. We also find that the illustrative day used in the Solar Cities Program literature to promote the notion of cost-reflective pricing is highly atypical. Finally, we consider ways in which the incentive to install distributed photovoltaic generation might be improved.     

Recent Progress in High-Speed Silicon-Based Optical Modulators

The evolution of silicon optical modulators is recalled, from the first effect demonstrations to the characterization of high-performance devices integrated in optical waveguides. Among possibilities to achieve optical modulation in silicon-based materials, the carrier depletion effect has demonstrated good capacities. Carrier depletion in Si and SiGe/Si structures has been theoretically and experimentally investigated. Large phase modulation efficiency, low optical loss, and large cutoff frequency are obtained by considering simultaneously optical and electrical structure performances. Integrated Mach-Zehnder interferometers and resonators are compared to convert phase modulation into intensity modulation. Finally, recent results on high-speed and low-loss silicon optical modulator using an asymmetric Mach-Zehnder interferometer are presented. It is based on a p-doped slit embedded in the intrinsic region of a lateral pin diode integrated in a silicon-on-insulator waveguide. This design allows a good overlap between the optical mode and carrier density variations. An insertion loss of 5 dB has been measured with a -3 dB bandwidth of 15 GHz.